Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Daniel Phaneuf"'
Autor:
Mari Carmen Pelaez, Antoine Desmeules, Pauline A. Gelon, Bastien Glasson, Laetitia Marcadet, Alicia Rodgers, Daniel Phaneuf, Silvia Pozzi, Paul A. Dutchak, Jean-Pierre Julien, Chantelle F. Sephton
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related neurodegenerative diseases that belong to a common disease spectrum based on overlapping clinical, pathological and genetic evidence. Early pathological change
Externí odkaz:
https://doaj.org/article/7607d7cbde0a4784a3e433fdc4157ae9
Autor:
Pooja Shree Mishra, Daniel Phaneuf, Hejer Boutej, Vincent Picher-Martel, Nicolas Dupre, Jasna Kriz, Jean-Pierre Julien
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1017 (2024)
The current knowledge on pathogenic mechanisms in amyotrophic lateral sclerosis (ALS) has widely been derived from studies with cell and animal models bearing ALS-linked genetic mutations. However, it remains unclear to what extent these disease mode
Externí odkaz:
https://doaj.org/article/62e30074d94d4c32bb2142994ca6efb2
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-17 (2021)
Abstract Background TDP-43 proteinopathy is a pathological hallmark of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). So far, there is no therapy available for these neurodegenerative
Externí odkaz:
https://doaj.org/article/0ed0977b186945afa534a8898167e228
Autor:
Saleh Mamun, Adriana Castillo-Castillo, Kristen Swedberg, Jiarui Zhang, Kevin J. Boyle, Diego Cardoso, Catherine L. Kling, Christoph Nolte, Michael Papenfus, Daniel Phaneuf, Stephen Polasky
Publikováno v:
Proceedings of the National Academy of Sciences. 120
High-quality water resources provide a wide range of benefits, but the value of water quality is often not fully represented in environmental policy decisions, due in large part to an absence of water quality valuation estimates at large, policy rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d83832214e29df8ff21ec3feea90f2
https://doi.org/10.1073/pnas.2210417120
https://doi.org/10.1073/pnas.2210417120
Publikováno v:
Neurotherapeutics. 18:286-296
Withaferin-A, an active withanolide derived from the medicinal herbal plant Withania somnifera induces autophagy, reduces TDP-43 proteinopathy, and improves cognitive function in transgenic mice expressing mutant TDP-43 modelling FTLD. TDP-43 is a nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df0d41101e47faf1b1e4e1c95f17389
https://doi.org/10.1007/s13311-020-00952-0
https://doi.org/10.1007/s13311-020-00952-0
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-17 (2021)
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-17 (2021)
Background TDP-43 proteinopathy is a pathological hallmark of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). So far, there is no therapy available for these neurodegenerative diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdb1b666638f18bc91f9016ffbebf87
https://pubmed.ncbi.nlm.nih.gov/33413517
https://pubmed.ncbi.nlm.nih.gov/33413517
Publikováno v:
Neurotherapeutics
Abnormal cytoplasmic mislocalization of transactive response DNA binding protein 43 (TARDBP or TDP-43) in degenerating neurons is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31346bedde3278a002bf8924b753bbfa
http://europepmc.org/articles/PMC5398980
http://europepmc.org/articles/PMC5398980
Autor:
Karine Valérie Plourde, Geneviève Soucy, Silvia Pozzi, Jasna Kriz, Christine Bareil, Reza Rahimian, Claude Gravel, Jean-Pierre Julien, Sai Sampath Thammisetty, Philippe Codron, Daniel Phaneuf
Publikováno v:
The Journal of clinical investigation. 129(4)
The cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of degenerating neurons in amyotrophic lateral sclerosis (ALS) and subsets of frontotemporal dementia (FTD). In order to reduce TDP-43 pathology, we generated single-cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7466fd3542bc5d609f55b8562afc35
https://pubmed.ncbi.nlm.nih.gov/30667370
https://pubmed.ncbi.nlm.nih.gov/30667370
Autor:
Mélanie Lalancette-Hébert, Jasna Kriz, Sai Sampath Thammisetty, Senthil Krishnasamy, Daniel Phaneuf, Yuan-Cheng Weng
Publikováno v:
Journal of Neuroinflammation
Background Nestin is a known marker of neuronal progenitor cells in the adult brain. Following neuro- and gliogenesis, nestin is replaced by cell type-specific intermediate filaments, e.g., neurofilaments for panneuronal expression and glial fibrilla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c27d01f3186dd619bbf60ba0a28e5f
https://doi.org/10.1186/s12974-017-0816-7
https://doi.org/10.1186/s12974-017-0816-7
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 113:116-126
Using serial analysis of gene expression, we examined the effects of estrogen (E2) replacement in gonadectomized wild type (WT) and E2 receptor alpha knockout (ERalphaKO) mice on global gene expression in mammary gland. In WT mice, a total of 429,302
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d94fd55bd45f1d43077259494037439
https://doi.org/10.1016/j.jsbmb.2008.12.002
https://doi.org/10.1016/j.jsbmb.2008.12.002