Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Daniel Pekin"'
Autor:
Trey Ideker, Jason F. Kreisberg, Kyle S. Sanchez, Alex Thomas, Kristin Klepper, John Paul Shen, Katherine Licon, Daniel Pekin, Nevan J. Krogan, Amanda Birmingham, Prashant Mali, Chih-Chung Kuo, Assen Roguev, Nathan E. Lewis, Aaron N. Chang, Lei S. Qi, Ana Bojorquez-Gomez, Dan Du, Roman Sasik, Jens Luebeck, Alex Beckett, Dongxin Zhao
Publikováno v:
Nature methods, vol 14, iss 6
Nature methods
Nature methods
We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs of 73 cancer genes with dual-guide RNAs in three cell lines, altogether c
Autor:
Katherine Licon, John Paul Shen, Ana Bojorquez-Gomez, Andrew M. Gross, Chu Ping Qiu, Huwate Yeerna, Jia L. Xu, Rohith Srivas, Haico van Attikum, Robert W. Sobol, Vignesh Sivaganesh, Su Ming Sun, Eric J. Jaehnig, Daniel Pekin, Jianfeng Li, Kristin Klepper, Trey Ideker
Publikováno v:
Oncotarget
Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we
Autor:
Robert W. Sobol, Justin K. Huang, Trey Ideker, Jianfeng Li, Jia L. Xu, Ana Bojorquez-Gomez, Andrew M. Gross, James Jensen, Leonie Kollenstart, Rohith Srivas, Daniel Pekin, John Paul Shen, Haico van Attikum, Kristin Klepper, Vignesh Sivaganesh, Chih Cheng Yang, Su Ming Sun, Pedro Aza-Blanc, Huwate Yeerna, Katherine Licon
Publikováno v:
Molecular Cell, 63(3), 514-525
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8619741cd89b289b24df77a20c39353
https://hdl.handle.net/1887/113262
https://hdl.handle.net/1887/113262
Autor:
Nick Rose
Australia's food system is more than just broken—it's killing us. The groundbreaking Fair Food: Inspiring People to Change the World tells the new story of food – the story of how food and farming in Australia are dramatically transforming at the