Synthesis and Critical View on the Structure-Activity Relationships of N-(Substituted phenyl)-/N-Diphenylmethyl-piperazine-Based Conjugates as Antimycobacterial Agents

Autor: Jana Čurillová, Mária Pecháčová, Tereza Padrtová, Daniel Pecher, Šárka Mascaretti, Josef Jampílek, Ľudmila Pašková, František Bilka, Gustáv Kováč, Ivan Malík

Publikováno v: Applied Sciences, Vol 12, Iss 1, p 300 (2021)

This research focused on a three-step synthesis, analytical, physicochemical, and biological evaluation of hybrid molecules 6a–g, containing a lipophilic 3-trifluoromethylphenyl moiety, polar carbamoyloxy bridge, 2-hydroxypropan-1,3-diyl chain and

Externí odkaz: https://doaj.org/article/3b7a2e01565f4fd98f8600142b84c427

Determination of Novel Highly Effective Necrostatin Nec-1s in Rat Plasma by High Performance Liquid Chromatography Hyphenated with Quadrupole-Time-of-Flight Mass Spectrometry

Autor: Peter Mikuš, Daniel Pecher, Drahomíra Rauová, Csaba Horváth, Adrián Szobi, Adriana Adameová

Publikováno v: Molecules, Vol 23, Iss 8, p 1946 (2018)

Necrostatins have been shown to retard necroptosis, a programmed necrotic-like cell death, which has been shown to underlie pathophysiology of various diseases. Nec-1s, a novel highly effective necrostatin, overcomes some drawbacks of former necrosta

Externí odkaz: https://doaj.org/article/c032515c0e1f4cd99017c6d1c5e43a1f

Optimization and Comparison of Synthetic Procedures for a Group of Triazinyl-Substituted Benzene-Sulfonamide Conjugates with Amino Acids

Autor: Dominika Krajčiová, Daniel Pecher, Vladimír Garaj, Peter Mikuš

Publikováno v: Molecules, Vol 22, Iss 9, p 1533 (2017)

Sulfonamides incorporating 1,3,5-triazine moieties can selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII, and XIV over cytosolic isoforms I and II. In the present work, a highly effective synthetic procedure was propo

Externí odkaz: https://doaj.org/article/c9cdccc29bd3426bbc5d3255fa6c0afb

Synthesis and Inhibition Activity Study of Triazinyl-Substituted Amino(alkyl)-benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Human Carbonic Anhydrases I, II, IV, IX, and XII

Autor: Mária Bodnár Mikulová, Dáša Kružlicová, Peter Mikuš, Daniel Pecher, Andrea Petreni, Claudiu T. Supuran

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11283, p 11283 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 20

Primary sulfonamide derivatives with various heterocycles represent the most widespread group of potential human carbonic anhydrase (hCA) inhibitors with high affinity and selectivity towards specific isozymes from the hCA family. In this work, new 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21d3eb7b6c06334468f4c485dc4f1d8
https://www.mdpi.com/1422-0067/22/20/11283

Porous graphitic carbon based chromatography hyphenated with mass spectrometry: A new strategy for profiling thiopurine nucleotides in patients with inflammatory bowel diseases

Autor: Peter Mikuš, Zuzana Zelinkova, Svetlana Dokupilová, Veronika Mikušová, Daniel Pecher, Jana Lucenicova, Maikel P. Peppelenbosch

Publikováno v: Analytica Chimica Acta, 1137, 64-73. Elsevier

Thiopurine (TP) treatment is discontinued in up to 30% of patients suffering from inflammatory bowel diseases (IBD) due to various adverse effects. Therapeutic drug monitoring of biologically active TP metabolites, i.e. thiopurine nucleotides (TPN),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb82a10f09e18148cdf7fe3b34566c1
https://pubmed.ncbi.nlm.nih.gov/33153610