Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Daniel Pecher"'
Autor:
Jana Čurillová, Mária Pecháčová, Tereza Padrtová, Daniel Pecher, Šárka Mascaretti, Josef Jampílek, Ľudmila Pašková, František Bilka, Gustáv Kováč, Ivan Malík
Publikováno v:
Applied Sciences, Vol 12, Iss 1, p 300 (2021)
This research focused on a three-step synthesis, analytical, physicochemical, and biological evaluation of hybrid molecules 6a–g, containing a lipophilic 3-trifluoromethylphenyl moiety, polar carbamoyloxy bridge, 2-hydroxypropan-1,3-diyl chain and
Externí odkaz:
https://doaj.org/article/3b7a2e01565f4fd98f8600142b84c427
Autor:
Mária Bodnár Mikulová, Dáša Kružlicová, Daniel Pecher, Andrea Petreni, Claudiu T. Supuran, Peter Mikuš
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11283 (2021)
Primary sulfonamide derivatives with various heterocycles represent the most widespread group of potential human carbonic anhydrase (hCA) inhibitors with high affinity and selectivity towards specific isozymes from the hCA family. In this work, new 4
Externí odkaz:
https://doaj.org/article/fb661280f4cb4ad999504fc87f792706
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3661 (2020)
Various sulfonamide derivatives are intensively studied as anticancer agents owing to their inhibitory activity against human tumor-associated carbonic anhydrase isoforms. In this work, different synthetic procedures for the series of 1,3,5-triazinyl
Externí odkaz:
https://doaj.org/article/d4ac745a421b4b559884cba3b5fa0360
Autor:
Ivan Malík, Jozef Csöllei, Ivan Solovič, Šárka Pospíšilová, Hana Michnová, Josef Jampílek, Alois Čížek, Iva Kapustíková, Jana Čurillová, Mária Pecháčová, Jiřina Stolaříková, Daniel Pecher, Michal Oravec
Publikováno v:
Molecules, Vol 23, Iss 10, p 2493 (2018)
In order to provide a more detailed view on the structure–antimycobacterial activity relationship (SAR) of phenylcarbamic acid derivatives containing two centers of protonation, 1-[2-[({[2-/3-(alkoxy)phenyl]amino}carbonyl)oxy]-3-(dipropylammonio)pr
Externí odkaz:
https://doaj.org/article/a973a3dd2d364f6ea1961027e53f435e
Publikováno v:
Molecules, Vol 23, Iss 8, p 1946 (2018)
Necrostatins have been shown to retard necroptosis, a programmed necrotic-like cell death, which has been shown to underlie pathophysiology of various diseases. Nec-1s, a novel highly effective necrostatin, overcomes some drawbacks of former necrosta
Externí odkaz:
https://doaj.org/article/c032515c0e1f4cd99017c6d1c5e43a1f
Autor:
Daniel Pecher, Svetlana Dokupilová, Zuzana Zelinková, Maikel Peppelenbosch, Jana Lučeničová, Veronika Mikušová, Peter Mikuš
Publikováno v:
Molecules, Vol 23, Iss 7, p 1744 (2018)
Thiopurines (TP) represent an important therapeutic tool for the treatment of inflammatory bowel diseases (IBD) in the current situation of rising incidence and health care costs. The results of multiple clinical studies aimed at finding correlations
Externí odkaz:
https://doaj.org/article/a031652354bf4ff39d9d6089a7d4e30a
Publikováno v:
Molecules, Vol 22, Iss 9, p 1533 (2017)
Sulfonamides incorporating 1,3,5-triazine moieties can selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII, and XIV over cytosolic isoforms I and II. In the present work, a highly effective synthetic procedure was propo
Externí odkaz:
https://doaj.org/article/c9cdccc29bd3426bbc5d3255fa6c0afb
Publikováno v:
Chemical Papers. 75:3081-3090
Critical micelle concentration (CMC) values of 1-[3-(2-alkoxyphenylcarbamoyloxy)-2-hydroxypropyl]-4-(4-fluorophenyl)piperazin-1-ium-chlorides (alkoxy = methoxy to propoxy; 6a–c) were determined by a fluorescence method using pyrene as a probe over
Autor:
Branislav Horváth, Peter Mikuš, Claudiu T. Supuran, Dominika Krajčiová, Andrea Angeli, Mária Bodnár Mikulová, Vladimír Garaj, Daniel Pecher, Silvia Bua
Publikováno v:
Bioorganic Chemistry. 81:241-252
A new series of thirty s-triazinyl-substituted aminoalkylbenzenesulfonamides, incorporating a symmetric pair of amino acid moieties, is reported, together with inhibition studies of physiologically relevant human carbonic anhydrase (hCA, EC 4.2.1.1)
Autor:
Peter Mikuš, Zuzana Zelinkova, Svetlana Dokupilová, Veronika Mikušová, Daniel Pecher, Jana Lucenicova, Maikel P. Peppelenbosch
Publikováno v:
Analytica Chimica Acta, 1137, 64-73. Elsevier
Thiopurine (TP) treatment is discontinued in up to 30% of patients suffering from inflammatory bowel diseases (IBD) due to various adverse effects. Therapeutic drug monitoring of biologically active TP metabolites, i.e. thiopurine nucleotides (TPN),