Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Daniel Panne"'
Autor:
Ziad Ibrahim, Tao Wang, Olivier Destaing, Nicola Salvi, Naghmeh Hoghoughi, Clovis Chabert, Alexandra Rusu, Jinjun Gao, Leonardo Feletto, Nicolas Reynoird, Thomas Schalch, Yingming Zhao, Martin Blackledge, Saadi Khochbin, Daniel Panne
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Here the authors use structural analyses to show that an intrinsically disordered transcription activation domain in the oncogene BRD4-NUT binds to and activates p300. This in-turn drives formation of higher-order, acetylation-dependent chromatin con
Externí odkaz:
https://doaj.org/article/df90f651ff344307887b5104e3d007a2
Autor:
Yi Zhang, Kyle Brown, Yucong Yu, Ziad Ibrahim, Mohamad Zandian, Hongwen Xuan, Steven Ingersoll, Thomas Lee, Christopher C. Ebmeier, Jiuyang Liu, Daniel Panne, Xiaobing Shi, Xiaojun Ren, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The histone acetyltransferase p300 mostly localizes to active chromatin; however, some repressed genes marked with H3K27me3 are also bound by p300. Here the authors show p300 is capable of phase separation, which relies on its catalytic core, and tha
Externí odkaz:
https://doaj.org/article/3a76054979544d3892894768400ab8c1
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2116-2126 (2016)
Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the stability with which the cohesin complex embraces chromosomes. One of these factors, Pds5,
Externí odkaz:
https://doaj.org/article/173d19a667874edcac0946409763af46
Autor:
Hitoshi Shiota, Sophie Barral, Thierry Buchou, Minjia Tan, Yohann Couté, Guillaume Charbonnier, Nicolas Reynoird, Fayçal Boussouar, Matthieu Gérard, Mingrui Zhu, Lisa Bargier, Denis Puthier, Florent Chuffart, Ekaterina Bourova-Flin, Sarah Picaud, Panagis Filippakopoulos, Afsaneh Goudarzi, Ziad Ibrahim, Daniel Panne, Sophie Rousseaux, Yingming Zhao, Saadi Khochbin
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3477-3487.e6 (2018)
Summary: Nuclear protein in testis (Nut) is a universal oncogenic driver in the highly aggressive NUT midline carcinoma, whose physiological function in male germ cells has been unclear. Here we show that expression of Nut is normally restricted to p
Externí odkaz:
https://doaj.org/article/df3c3fd21a274a8b95f2d28fef81b222
Publikováno v:
eLife, Vol 7 (2018)
The cohesin ring complex is required for numerous chromosomal transactions including sister chromatid cohesion, DNA damage repair and transcriptional regulation. How cohesin engages its chromatin substrate has remained an unresolved question. We show
Externí odkaz:
https://doaj.org/article/5cc5282028dc4d4ebbcaa3a2d43703b8
Autor:
Paul Victor Sauer, Jennifer Timm, Danni Liu, David Sitbon, Elisabetta Boeri-Erba, Christophe Velours, Norbert Mücke, Jörg Langowski, Françoise Ochsenbein, Geneviève Almouzni, Daniel Panne
Publikováno v:
eLife, Vol 6 (2017)
How the very first step in nucleosome assembly, deposition of histone H3-H4 as tetramers or dimers on DNA, is accomplished remains largely unclear. Here, we report that yeast chromatin assembly factor 1 (CAF1), a conserved histone chaperone complex t
Externí odkaz:
https://doaj.org/article/13159998535b4ce984485d81f26c20d9
Autor:
Amede Larabi, Juliette M. Devos, Sze-Ling Ng, Max H. Nanao, Adam Round, Tom Maniatis, Daniel Panne
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 734-746 (2013)
Tank-binding kinase I (TBK1) plays a key role in the innate immune system by integrating signals from pattern-recognition receptors. Here, we report the X-ray crystal structures of inhibitor-bound inactive and active TBK1 determined to 2.6 Å and 4.0
Externí odkaz:
https://doaj.org/article/f5bd41946b59419fb6925a7bc6c42a50
Autor:
Alberto García-Nieto, Amrita Patel, Yan Li, Roel Oldenkamp, Leonardo Feletto, Joshua J. Graham, Laureen Willems, Kyle W. Muir, Daniel Panne, Benjamin D. Rowland
Publikováno v:
Nature Structural & Molecular Biology.
In the early stages of mitosis, cohesin is released from chromosome arms but not from centromeres. The protection of centromeric cohesin by SGO1 maintains the sister chromatid cohesion that resists the pulling forces of microtubules until all chromos
Publikováno v:
Nature structural & molecular biology
Genome regulation requires control of chromosome organization by SMC–kleisin complexes. The cohesin complex contains the Smc1 and Smc3 subunits that associate with the kleisin Scc1 to form a ring-shaped complex that can topologically engage chromat
Autor:
Mohamad Zandian, Daniel Panne, Kyle Brown, Yucong Yu, Jiuyang Liu, Xiaobing Shi, Xiaojun Ren, Tatiana G. Kutateladze, Christopher C. Ebmeier, Hongwen Xuan, Thomas Lee, Yi Zhang, Ziad Ibrahim, Steven Ingersoll
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
'Nature Communications ', vol: 12, pages: 4618-1-4618-15 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 4618-1-4618-15 (2021)
Nature Communications
The transcriptional co-activator and acetyltransferase p300 is required for fundamental cellular processes, including differentiation and growth. Here, we report that p300 forms phase separated condensates in the cell nucleus. The phase separation ab