Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Daniel P. Michaelson"'
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-17 (2019)
Abstract Background The growing body of evidence indicating the heterogeneity of Alzheimer’s disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy, suggest that the development of a single magic cure suitable f
Externí odkaz:
https://doaj.org/article/6fb54bb40292415b913c4b2465690452
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Introduction Alzheimer's disease (AD) and synucleinopathies share common pathological mechanisms. Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for AD, also increases the risk for dementia in pure synucleinopathies. We pr
Externí odkaz:
https://doaj.org/article/7bca9a669cd342b0b39800ccbc9de423
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 11, Pp 2083-2101 (2017)
In the last decade, it has become obvious that Alzheimer's disease (AD) is closely linked to changes in lipids or lipid metabolism. One of the main pathological hallmarks of AD is amyloid-β (Aβ) deposition. Aβ is derived from sequential proteolyti
Externí odkaz:
https://doaj.org/article/e49e3095dc814caea6d04ab695f8bdfc
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 1, Iss 2, Pp 127-135 (2015)
Abstract Apolipoprotein E4 (APOE ε4) is the most prevalent genetic risk factor for Alzheimer's disease (AD). Targeted replacement mice that express either APOE ε4 or its AD benign isoform, APOE ε3, are used extensively in behavioral, biochemical,
Externí odkaz:
https://doaj.org/article/41a366fb7ee44bd7a0410cdcdd184814
Autor:
Anat Boehm-Cagan, Roni Bar, Dror Harats, Aviv Shaish, Hana Levkovitz, John K Bielicki, Jan O Johansson, Daniel M Michaelson
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166195 (2016)
Apolipoprotein E4 (apoE4), the leading genetic risk factor for Alzheimer's disease (AD), is less lipidated compared to the most common and AD-benign allele, apoE3. We have recently shown that i.p. injections of the ATP-binding cassette A1 (ABCA1) ago
Externí odkaz:
https://doaj.org/article/e7ac0f8c755248ca9de611fed2609c35
Autor:
Gal Ophir, Ninette Amariglio, Jasmine Jacob-Hirsch, Ran Elkon, Gideon Rechavi, Daniel M. Michaelson
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 3, Pp 709-718 (2005)
Apolipoprotein E4 (apoE4), the major genetic risk factor of Alzheimer's disease (AD), is associated with enhanced brain inflammation. Genome-wide gene expression profiling was employed to study the effects of apoE genotype on hippocampal gene express
Externí odkaz:
https://doaj.org/article/9d3a93c2be95420d946cbdbab74e3906
Publikováno v:
Neurobiology of Disease, Vol 13, Iss 3, Pp 273-282 (2003)
Alzheimer’s disease (AD) is associated with genetic risk factors, of which the allele E4 of apolipoprotein E (apoE4) is the most prevalent, and is affected by environmental factors that include education early in life and socioeconomic background.
Externí odkaz:
https://doaj.org/article/ed56fc2b571441d7904ea938e9a51de9
Autor:
Gal Ophir, Sigal Meilin, Margalit Efrati, Joab Chapman, Dimitri Karussis, Allen Roses, Daniel M Michaelson
Publikováno v:
Neurobiology of Disease, Vol 12, Iss 1, Pp 56-64 (2003)
The allele E4 of apolipoprotein E (apoE) is an important risk factor for Alzheimer’s disease (AD) and the chronic brain inflammation which is associated with AD is more pronounced in subjects who carry this allele. In the present study, we employed
Externí odkaz:
https://doaj.org/article/aa14c8444e1846f8acaf71a89d61fce5
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64949 (2013)
The vertebrate retina, which is part of the central nervous system, is a window into the brain. The present study investigated the extent to which the retina can be used as a model for studying the pathological effects of apolipoprotein E4 (apoE4), t
Externí odkaz:
https://doaj.org/article/ca1c101dfc214847844fda37598712e3
Autor:
Lia Zepa, Moran Frenkel, Haim Belinson, Zehavit Kariv-Inbal, Rakez Kayed, Eliezer Masliah, Daniel M. Michaelson
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Activating the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin in targeted replacement mice, which express either apoE4 or apoE3, results in the specific accumulation of oligomerized Aβ42 in hippocampal CA1 neurons of the apoE4 mic
Externí odkaz:
https://doaj.org/article/cb1bfef81d92434aa6dfa693133c056b