Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Daniel P. Lim"'
Autor:
S. John Liu, Christopher Zou, Joanna Pak, Alexandra Morse, Dillon Pang, Timothy Casey-Clyde, Ashir A. Borah, David Wu, Kyounghee Seo, Thomas O’Loughlin, Daniel A. Lim, Tomoko Ozawa, Mitchel S. Berger, Roarke A. Kamber, William A. Weiss, David R. Raleigh, Luke A. Gilbert
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-32 (2024)
Abstract Background Genetic perturbation screens with single-cell readouts have enabled rich phenotyping of gene function and regulatory networks. These approaches have been challenging in vivo, especially in adult disease models such as cancer, whic
Externí odkaz:
https://doaj.org/article/ce15256d82df4ae7a07d376548cbf5c6
Autor:
Parna Saha, Rebecca E. Andersen, Sung Jun Hong, Eugene Gil, Jeffrey Simms, Hyeonseok Choi, Daniel A. Lim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The aberrant expression of specific long noncoding RNAs (lncRNAs) has been associated with cognitive and psychiatric disorders. Although a growing number of lncRNAs are now known to regulate neural cell development and function, relatively f
Externí odkaz:
https://doaj.org/article/36f902ccbc7a4a548ad9f929fe090810
Autor:
Xuan Ying Poh, I. Russel Lee, Chee Wah Tan, Jean-Marc Chavatte, Siew Wai Fong, Yun Shan Goh, Angeline Rouers, Nathan Wong, Anthony Torres-Ruesta, Shirley Y.Y. Mah, Aileen Y.Y. Yeoh, Mihir Gandhi, Nabilah Rahman, Yi Qing Chin, J. Jonathan Lim, Terence J.K. Yoong, Suma Rao, Po Ying Chia, Sean W.X. Ong, Tau Hong Lee, Sapna P. Sadarangani, Ray J.H. Lin, Daniel R.X. Lim, Wanni Chia, Laurent Renia, Ee Chee Ren, Raymond T.P. Lin, David C. Lye, Lin-Fa Wang, Lisa F.P. Ng, Barnaby E. Young
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105275- (2024)
Summary: Background: Understanding how SARS-CoV-2 breakthrough infections impacts the breadth of immune responses against existing and pre-emergent SARS-CoV-2 strains is needed to develop an evidence-based long-term immunisation strategy. Methods: We
Externí odkaz:
https://doaj.org/article/4ec8750f0a144a5283fffeb6b9790a82
Autor:
Eunice X. Tan, MBBS, MMED, MRCP, Wen Hui Lim, MBBS, Elizabeth Thong, MBBS, Jean-Marc Chavatte, PhD, Jinyan Zhang, MBBS, Jonathan Lim, MBBS, Jocelyn Y. Jin, PhD, Daniel R.X. Lim, MBBS, Jaclyn Y.T. Kang, MBBS, Ansel Shao Pin Tang, MBBS, Kai En Chan, MBBS, Caitlyn Tan, MBBS, Shi Ni Tan, MBBS, Benjamin Nah, MBBS, MRCP, Daniel Q. Huang, MBBS, MMED, MRCP, Lin-Fa Wang, PhD, Paul A. Tambyah, MBBS, Diplomate ABIMID, Jyoti Somani, AB, MD, Diplomate ABIMID, Barnaby Young, MSc, MB, BChir, MRCP, DLSHTM, Mark D. Muthiah, MBBS, MRCP, MMed
Publikováno v:
Transplantation Direct, Vol 9, Iss 10, p e1537 (2023)
Background. Immunocompromised individuals have been excluded from landmark studies of messenger RNA vaccinations for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). In such patients, the response to vaccination may be blunted and m
Externí odkaz:
https://doaj.org/article/df41a18ddb4f4cf2b43c28be1ef23d0a
Autor:
Stephen T. Magill, Harish N. Vasudevan, Kyounghee Seo, Javier E. Villanueva-Meyer, Abrar Choudhury, S. John Liu, Melike Pekmezci, Sarah Findakly, Stephanie Hilz, Sydney Lastella, Benjamin Demaree, Steve E. Braunstein, Nancy Ann Oberheim Bush, Manish K. Aghi, Philip V. Theodosopoulos, Penny K. Sneed, Adam R. Abate, Mitchel S. Berger, Michael W. McDermott, Daniel A. Lim, Erik M. Ullian, Joseph F. Costello, David R. Raleigh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperativel
Externí odkaz:
https://doaj.org/article/009c5504e81841cb823079d832c9273c
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma
Autor:
S. John Liu, Martina Malatesta, Brian V. Lien, Parna Saha, Shivani S. Thombare, Sung Jun Hong, Leslie Pedraza, Mark Koontz, Kyounghee Seo, Max A. Horlbeck, Daniel He, Harjus S. Birk, Miten Jain, Hugh E. Olsen, Mark Akeson, Jonathan S. Weissman, Michelle Monje, Nalin Gupta, David R. Raleigh, Erik M. Ullian, Daniel A. Lim
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potent
Externí odkaz:
https://doaj.org/article/158146c58ea3458da92657b2d5201345
Autor:
Paton Vuong, Daniel J. Lim, Daniel V. Murphy, Michael J. Wise, Andrew S. Whiteley, Parwinder Kaur
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The accumulation of petroleum-based plastic waste has become a major issue for the environment. A sustainable and biodegradable solution can be found in Polyhydroxyalkanoates (PHAs), a microbially produced biopolymer. An analysis of the global phylog
Externí odkaz:
https://doaj.org/article/3ab8da7ca85f44b990cecef2131ba17f
Autor:
Arantxa Cebrian-Silla, Marcos Assis Nascimento, Stephanie A Redmond, Benjamin Mansky, David Wu, Kirsten Obernier, Ricardo Romero Rodriguez, Susana Gonzalez-Granero, Jose Manuel García-Verdugo, Daniel A Lim, Arturo Álvarez-Buylla
Publikováno v:
eLife, Vol 10 (2021)
The ventricular-subventricular zone (V-SVZ), on the walls of the lateral ventricles, harbors the largest neurogenic niche in the adult mouse brain. Previous work has shown that neural stem/progenitor cells (NSPCs) in different locations within the V-
Externí odkaz:
https://doaj.org/article/208c75771fe3475ca4f1ea2e534cf512
Autor:
Nalin Gupta, Roland G. Henry, Sang-Mo Kang, Jonathan Strober, Daniel A. Lim, Tamara Ryan, Rachel Perry, Jody Farrell, Mary Ulman, Raja Rajalingam, Allyson Gage, Stephen L. Huhn, A. James Barkovich, David H. Rowitch
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 254-261 (2019)
Summary: Four boys with Pelizaeus-Merzbacher disease, an X-linked leukodystrophy, underwent transplantation with human allogeneic central nervous system stem cells (HuCNS-SC). Subsequently, all subjects were followed for an additional 4 years in this
Externí odkaz:
https://doaj.org/article/0161355bf0d14e528a3f474182940e86
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-
Externí odkaz:
https://doaj.org/article/8699db1867984f5a93987afc657778dc