Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Daniel P. Hewitt"'
Publikováno v:
Livers, Vol 4, Iss 1, Pp 36-50 (2024)
Artificial Intelligence (AI) can be a useful tool in the management of disease processes such as hepatocellular carcinoma (HCC) as treatment decisions are often complex and multifaceted. AI applications in medicine are expanding with the ongoing adva
Externí odkaz:
https://doaj.org/article/fc6a497f03f546d4adda377e2fb361fc
Publikováno v:
Movement Ecology, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Background Effective fisheries management of mobile species relies on robust knowledge of animal behaviour and habitat-use. Indices of behaviour can be useful for interpreting catch-per-unit-effort data which acts as a proxy for relative abu
Externí odkaz:
https://doaj.org/article/414c74c02f244b8d96d2feaea98f1ee1
Publikováno v:
Cancers, Vol 14, Iss 19, p 4602 (2022)
Surgical management combined with improved systemic therapies have extended 5-year overall survival beyond 50% among patients with colorectal liver metastases (CRLM). Furthermore, a multitude of liver-directed therapies has improved local disease con
Externí odkaz:
https://doaj.org/article/be666002e6da446da6077440423d66ab
Autor:
Michelle Irwin, Tomasz K. Baginski, Leslie Welch, Daniel P. Hewitt, Christina Tsai, Luke McCarty, Xiao Dong
Publikováno v:
Journal of Chromatography B. 1092:158-167
Free thiol content, and its consistency, is one of the product quality attributes of interest during technical development of manufactured recombinant monoclonal antibodies (mAbs). We describe a new, mid/high-throughput reversed-phase-high performanc
Autor:
Junyan Ji, Yung-Hsiang Kao, Ming Lei, Diane Beane, Jimmy Sugahara, Christopher Cornell, Daniel P. Hewitt, Ken Skidmore
Publikováno v:
Biotechnology Progress. 29:1503-1511
Polysorbate 20 (PS-20) is often included in the formulation for therapeutic proteins to reduce protein aggregation and surface adsorption. During the production process of therapeutic proteins, various membrane filters are used to filter product pool
Autor:
Ben Tran, Zhihua Julia Qiu, Taylor Zhang, Daniel P. Hewitt, Hélène Gazzano-Santoro, Max L. Tejada, Yung-Hsiang Kao, Xiaoying Gao, Jennifer Zhang
Publikováno v:
Analytical Chemistry. 84:7112-7123
The heterogeneity in therapeutic antibodies arising from buried unpaired cysteines has not been well studied. This paper describes the characterization of two unpaired cysteines in a recombinant humanized IgG1 monoclonal antibody (referred to as mAb
Autor:
Melissa Alvarez, Kathryn Robinson, Taylor Zhang, Yung-Hsiang Kao, Y. John Wang, Junyan Ji, Daniel P. Hewitt
Publikováno v:
Journal of Chromatography A. 1218:2138-2145
Polysorbate 20 (polyoxyethylenesorbitan monolaurate) and polysorbate 80 (polyoxyethylenesorbitan monooleate) used in protein drug formulations are complex mixtures that have been difficult to characterize. Here, two HPLC methods are used with evapora
Publikováno v:
Chromatographia. 72:145-149
A quantitative method for measuring polyvinylsulfonic acid (PVS) concentrations in 2-(N-morpholino)ethanesulfonic acid (MES) is described here. Utilizing a TSK-GEL G2500PWxl SEC column, PVS elutes in the void volume as a sharp peak, yielding group se
Publikováno v:
Journal of Chromatography A. 1215:156-160
An HPLC assay requiring no complex sample preparation for the measurement of polysorbate 20 in protein solutions was developed. An on-off chromatography technique was employed involving a mixed-mode stationary phase (Waters Oasis MAX, mixed-mode anio
Publikováno v:
Nano Letters. 3:125-129
Chevrel-type LiMo3Se3 nanowires dissolved in dimethyl sulfoxide were decorated with 13 nm citrate ligated Au particles (water) and 6 nm trioctylphosphineoxide ligated CdSe particles (tetrahydrofuran) by combining the respective solutions at room temp