Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Daniel P. Fitzsimons"'
Autor:
Kyrah L. Turner, Haley S. Morris, Peter O. Awinda, Daniel P. Fitzsimons, Bertrand C.W. Tanner
Publikováno v:
Journal of General Physiology. 155
Hypertrophic cardiomyopathy (HCM) is the leading genetic cause of heart disease. The heart comprises several proteins that work together to properly facilitate force production and pump blood throughout the body. Cardiac myosin binding protein-C (cMy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d0996fef9b861813bd545f5a9eb5078
https://doi.org/10.1085/jgp.202213250
https://doi.org/10.1085/jgp.202213250
Autor:
Richard L. Moss, Wenxuan Cai, Jitandrakumar R. Patel, Rachel Heurer, Ziqing Lin, Daniel P. Fitzsimons, Zachery R. Gregorich, Ying Ge
Publikováno v:
The Journal of General Physiology
Enigma Homologue (ENH) is a Z-disc protein whose loss causes cardiomyopathy, but whose function in muscle mechanics is poorly understood. Gregorich et al. show that ENH affects tension redevelopment in mouse myocardium, possibly by altering cross-bri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9320d3f3e1aef535478a6b74bd7ccb
https://doi.org/10.1085/jgp.201812214
https://doi.org/10.1085/jgp.201812214
Autor:
Jasmine Giles, Adam Miller, Elizabeth Iverson, Richard L. Moss, Daniel P. Fitzsimons, Jitandrakumar R. Patel
Publikováno v:
The Journal of General Physiology
Knockdown of cardiac myosin binding protein C (cMyBP-C), which is the cause of many cases of hypertrophic cardiomyopathy in humans, results in left ventricular dilation, cardiac hypertrophy, and impaired ventricular function, but it is unclear whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0115491423e2dcbd579c4bcacb92878
https://doi.org/10.1085/jgp.201812238
https://doi.org/10.1085/jgp.201812238
Publikováno v:
The Journal of General Physiology
Cardiac myosin-binding protein C (cMyBP-C) is thought to regulate cardiac muscle and heart contraction. Hanft et al. show that cMyBP-C phosphorylation regulates length dependence of power output in murine permeabilized cardiac myocytes, which transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6aba5c9d76ed4ea68c2dd395512ccca
https://doi.org/10.1085/jgp.202012770
https://doi.org/10.1085/jgp.202012770
Autor:
Richard L. Moss, Chloe Knudtsen, Jasmine Giles, Daniel P. Fitzsimons, Zander Neuville, Jitandrakumar R. Patel
Publikováno v:
The Journal of General Physiology
Giles et al. show that the phosphorylation status of cardiac myosin-binding protein-C (cMyBP-C) modulates Ca2+ activation–dependent unloaded shortening velocity of skinned myocardium. The results suggest that cMyBP-C phosphorylation regulates coope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9883012173af9fa9548950a0f086968
https://pubmed.ncbi.nlm.nih.gov/33566084
https://pubmed.ncbi.nlm.nih.gov/33566084
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2604 (2008)
Alpha-dystrobrevin is a component of the dystrophin-glycoprotein complex (DGC) and is thought to have both structural and signaling roles in skeletal muscle. Mice deficient for alpha-dystrobrevin (adbn(-/-)) exhibit extensive myofiber degeneration an
Externí odkaz:
https://doaj.org/article/f44a2f19637d4a8fb17d315a17b8283d
Publikováno v:
Biophysical Journal. 118:595a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a769c4596e3faeef1c2bad32115e6143
https://doi.org/10.1016/j.bpj.2019.11.3220
https://doi.org/10.1016/j.bpj.2019.11.3220
Publikováno v:
Circulation Research. 116:183-192
Cardiac myosin–binding protein-C (cMyBP-C) is a thick filament-associated protein that seems to contribute to the regulation of cardiac contraction through interactions with either myosin or actin or both. Several studies over the past several year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c64582b105a27671cabfd9f083bcbfa
https://doi.org/10.1161/circresaha.116.300561
https://doi.org/10.1161/circresaha.116.300561
Publikováno v:
The Journal of General Physiology
High-frequency paired stimuli used to initiate a tetanus result in increased force and rate of force development in skeletal muscle. Bakker et al. investigate this mechanism and find that doublet stimulation increases the amount of Ca2+ bound to trop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fab552cda2b30e77843cb1693a882d
https://pubmed.ncbi.nlm.nih.gov/28209802
https://pubmed.ncbi.nlm.nih.gov/28209802
Publikováno v:
Journal of Molecular and Cellular Cardiology. 124:106-107
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0f3e51d167a498bfa7ce89ef51da12d
https://doi.org/10.1016/j.yjmcc.2018.07.073
https://doi.org/10.1016/j.yjmcc.2018.07.073