Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Daniel P. Dowling"'
Publikováno v:
Current opinion in chemical biology. 72
Ox-/thiazoline groups in nonribosomal peptides are formed by a variant of peptide-forming condensation domains called heterocyclization (Cy) domains and appear in a range of pharmaceutically important natural products and virulence factors. Recent cr
Autor:
Subrata H. Mishra, Aswani K. Kancherla, Kenneth A. Marincin, Guillaume Bouvignies, Santrupti Nerli, Nikolaos Sgourakis, Daniel P. Dowling, Dominique P. Frueh
Publikováno v:
Science advances. 8(28)
Biological activity is governed by the timely redistribution of molecular interactions, and static structural snapshots often appear insufficient to provide the molecular determinants that choreograph communication. This conundrum applies to multidom
Publikováno v:
The FASEB Journal. 36
Autor:
Andrew D. Gnann, Yuan Xia, Jess Soule, Clara Barthélemy, Jayata S. Mawani, Sarah Nzikoba Musoke, Brian M. Castellano, Edward J. Brignole, Dominique P. Frueh, Daniel P. Dowling
Publikováno v:
The Journal of biological chemistry. 298(10)
Nonribosomal peptide synthetase heterocyclization (Cy) domains generate biologically important oxazoline/thiazoline groups found in natural products, including pharmaceuticals and virulence factors such as some siderophores. Cy domains catalyze conse
Autor:
Jonathan Webb, Jeremy J.M. Liew, Andrew D. Gnann, MacKenzie Patterson, Sayantanee Paul, Marta Forés, Gerardo Jiménez, Alexey Veraksa, Daniel P. Dowling
The HMG-box protein Capicua (CIC) is an evolutionarily conserved transcriptional repressor with key functions in development and disease-associated processes. CIC binds DNA using an exclusive mechanism that requires both its HMG-box and a separate do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e72d3756da3754f99d3f89c4157a39
https://doi.org/10.1101/2022.03.28.485992
https://doi.org/10.1101/2022.03.28.485992
Autor:
Andrew D. Gnann, Yuan Xia, Jess Soule, Clara Barthélemy, Jayata Mawani, Sarah Nzikoba Musoke, Brian Castellano, Edward Brignole, Dominique Frueh, Daniel P. Dowling
Nonribosomal peptide synthetase (NRPS) heterocyclization (Cy) domains generate biologically important ox-/thiazoline modifications in natural products, including in production of compounds targeting disease or siderophores that are important for bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caac9211b1dcc011cbe078e156653250
https://doi.org/10.1101/2022.03.18.483834
https://doi.org/10.1101/2022.03.18.483834
Autor:
Santrupti Nerli, Aswani K. Kancherla, Subrata H. Mishra, Kenneth A. Marincin, Nikolaos G. Sgourakis, Dominique P. Frueh, Guillaume Bouvignies, Daniel P. Dowling
Structural biology is the foundation for deriving molecular mechanisms, where snapshots of macromolecules and binding partners inform on mutations that test or modify function. However, frequently, the impact of mutations violates the underpinnings o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::425a76eaad3b33c65bdba0f3972f5ae4
https://doi.org/10.1101/2021.10.06.461881
https://doi.org/10.1101/2021.10.06.461881
Autor:
Janani Sridar, Ivan R. Corrêa, Chudi Guan, Mackenzie J. Parker, Krutika Nayak, Yan-Jiun Lee, Stephanie I Müller, Katherine Marks, Daniel P. Dowling, Shannon E. Walsh, Lana Saleh, Morgan E. Fraser, Zhiyi Sun, Andrew Mulholland, Nan Dai, Vahe Bandarian, Peter Weigele, Donald G. Comb, Reyaz Gonzalez, Yu-Cheng Lin
Publikováno v:
Nucleic acids research. 50(6)
The DNAs of bacterial viruses are known to contain diverse, chemically complex modifications to thymidine that protect them from the endonuclease-based defenses of their cellular hosts, but whose biosynthetic origins are enigmatic. Up to half of thym
Publikováno v:
The FASEB Journal. 35
Autor:
Kylie C. McKenna, Jess Soule, Andrew Gnann, Son V. Nguyen, Reyaz Gonzalez, Denyce K. Wicht, Ngan T. Phan, Daniel P. Dowling, Mackenzie J. Parker
Publikováno v:
Biochemical and biophysical research communications. 522(1)
Methyl sulfur compounds are a rich source of environmental sulfur for microorganisms, but their use requires redox systems. The bacterial sfn and msu operons contain two-component flavin-dependent monooxygenases for dimethylsulfone (DMSO2) assimilati