Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Daniel P Leaman"'
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004271 (2014)
Human antibody 10E8 targets the conserved membrane proximal external region (MPER) of envelope glycoprotein (Env) subunit gp41 and neutralizes HIV-1 with exceptional potency. Remarkably, HIV-1 containing mutations that reportedly knockout 10E8 bindin
Externí odkaz:
https://doaj.org/article/00dbd61ddb5f49c1aac739e1844f96e3
Autor:
Daniel P Leaman, Michael B Zwick
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003184 (2013)
The functional HIV-1 envelope glycoprotein (Env) trimer, the target of anti-HIV-1 neutralizing antibodies (Abs), is innately labile and coexists with non-native forms of Env. This lability and heterogeneity in Env has been associated with its tendenc
Externí odkaz:
https://doaj.org/article/58098518fd35421a96be0cc88affbdad
Autor:
Kristin M Narayan, Nitish Agrawal, Sean X Du, Janelle E Muranaka, Katherine Bauer, Daniel P Leaman, Pham Phung, Kay Limoli, Helen Chen, Rebecca I Boenig, Terri Wrin, Michael B Zwick, Robert G Whalen
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52732 (2013)
Development of a vaccine for HIV-1 requires a detailed understanding of the neutralizing antibody responses that can be experimentally elicited to difficult-to-neutralize primary isolates. Rabbits were immunized with the gp120 subunit of HIV-1 JR-CSF
Externí odkaz:
https://doaj.org/article/373c90d7de20468bbbf0e4d14fa246f4
Autor:
Nitish Agrawal, Daniel P Leaman, Eric Rowcliffe, Heather Kinkead, Raman Nohria, Junya Akagi, Katherine Bauer, Sean X Du, Robert G Whalen, Dennis R Burton, Michael B Zwick
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21339 (2011)
The HIV-1 envelope glycoprotein (Env) spike is challenging to study at the molecular level, due in part to its genetic variability, structural heterogeneity and lability. However, the extent of lability in Env function, particularly for primary isola
Externí odkaz:
https://doaj.org/article/0bc298437a524bf4a846d93e17880be2
Autor:
Eirini Vamva, Stosh Ozog, Daniel P. Leaman, Rene Yu-Hong Cheng, Nicholas J. Irons, Andee Ott, Claire Stoffers, Iram Khan, Geraldine K.E. Goebrecht, Matthew R. Gardner, Michael Farzan, David J. Rawlings, Michael B. Zwick, Richard G. James, Bruce E. Torbett
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 366-384 (2023)
Barriers to effective gene therapy for many diseases include the number of modified target cells required to achieve therapeutic outcomes and host immune responses to expressed therapeutic proteins. As long-lived cells specialized for protein secreti
Externí odkaz:
https://doaj.org/article/5335a8f9645a42be9c9d7d049a240b62
Autor:
Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel García-Porras, Eneko Largo, Izaskun Morillo, Rubén Sánchez-Eugenia, Lei Zhang, Hong Cui, Ibon Iloro, Félix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B. Zwick, Jose M.M. Caaveiro, José L. Nieva
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102987- (2021)
Summary: Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the conserved Membrane pr
Externí odkaz:
https://doaj.org/article/f69c2aef00f544b7909cd6e9049a9b2c
Autor:
Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, Michael B. Zwick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis s
Externí odkaz:
https://doaj.org/article/706277bc9dfa4fb4814343163603b088
Autor:
Vidya Mangala Prasad, Daniel P. Leaman, Klaus N. Lovendahl, Jacob T. Croft, Mark A. Benhaim, Edgar A. Hodge, Michael B. Zwick, Kelly K. Lee
SummaryHIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion context has eluded detailed characterization. Here we used cryo-electron tomography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bc0ea8ce0731c1393498d3fdcceb9b3
https://doi.org/10.1101/2021.08.31.458345
https://doi.org/10.1101/2021.08.31.458345
Publikováno v:
J Virol
A major goal of HIV vaccine design is to elicit broadly neutralizing antibodies (bNAbs). Such bNAbs target HIV’s trimeric, membrane-embedded envelope glycoprotein spikes (mEnv). Soluble Env (sEnv) trimers have been used as vaccines, but engineering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a048b9b6ee326d0ee421d5e14cfff5
https://doi.org/10.1128/jvi.00005-21
https://doi.org/10.1128/jvi.00005-21
Autor:
Pascal Poignard, Daniel P. Leaman, Jiang Zhu, Kimmo Rantalainen, Armando Stano, Michael B. Zwick, Andrew B. Ward, Adriana Irimia, Daniel I. Sands, Ian A. Wilson, Thomas Vollbrecht, Dennis R. Burton, Arthur S. Kim, Lei Zhang, Elise Landais, Ben Murrell, Lingling He
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER antibodies usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f122d9dd5cd45602f0b6d142d1fc270
http://link.springer.com/article/10.1038/s41467-019-12973-1
http://link.springer.com/article/10.1038/s41467-019-12973-1