Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Daniel P Fitzsimons"'
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2604 (2008)
Alpha-dystrobrevin is a component of the dystrophin-glycoprotein complex (DGC) and is thought to have both structural and signaling roles in skeletal muscle. Mice deficient for alpha-dystrobrevin (adbn(-/-)) exhibit extensive myofiber degeneration an
Externí odkaz:
https://doaj.org/article/f44a2f19637d4a8fb17d315a17b8283d
Autor:
Kyrah L. Turner, Haley S. Morris, Peter O. Awinda, Daniel P. Fitzsimons, Bertrand C.W. Tanner
Publikováno v:
Journal of General Physiology. 155
Hypertrophic cardiomyopathy (HCM) is the leading genetic cause of heart disease. The heart comprises several proteins that work together to properly facilitate force production and pump blood throughout the body. Cardiac myosin binding protein-C (cMy
Autor:
Richard L. Moss, Wenxuan Cai, Jitandrakumar R. Patel, Rachel Heurer, Ziqing Lin, Daniel P. Fitzsimons, Zachery R. Gregorich, Ying Ge
Publikováno v:
The Journal of General Physiology
Enigma Homologue (ENH) is a Z-disc protein whose loss causes cardiomyopathy, but whose function in muscle mechanics is poorly understood. Gregorich et al. show that ENH affects tension redevelopment in mouse myocardium, possibly by altering cross-bri
Autor:
Jasmine Giles, Adam Miller, Elizabeth Iverson, Richard L. Moss, Daniel P. Fitzsimons, Jitandrakumar R. Patel
Publikováno v:
The Journal of General Physiology
Knockdown of cardiac myosin binding protein C (cMyBP-C), which is the cause of many cases of hypertrophic cardiomyopathy in humans, results in left ventricular dilation, cardiac hypertrophy, and impaired ventricular function, but it is unclear whethe
Autor:
Richard L. Moss, Chloe Knudtsen, Jasmine Giles, Daniel P. Fitzsimons, Zander Neuville, Jitandrakumar R. Patel
Publikováno v:
The Journal of General Physiology
Giles et al. show that the phosphorylation status of cardiac myosin-binding protein-C (cMyBP-C) modulates Ca2+ activation–dependent unloaded shortening velocity of skinned myocardium. The results suggest that cMyBP-C phosphorylation regulates coope
Publikováno v:
Biophysical Journal. 118:595a
Publikováno v:
Circulation Research. 116:183-192
Cardiac myosin–binding protein-C (cMyBP-C) is a thick filament-associated protein that seems to contribute to the regulation of cardiac contraction through interactions with either myosin or actin or both. Several studies over the past several year
Publikováno v:
The Journal of General Physiology
High-frequency paired stimuli used to initiate a tetanus result in increased force and rate of force development in skeletal muscle. Bakker et al. investigate this mechanism and find that doublet stimulation increases the amount of Ca2+ bound to trop
Publikováno v:
Journal of Molecular and Cellular Cardiology. 124:106-107
Publikováno v:
Biophysical Journal. 116:116a