Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Daniel P Depledge"'
Autor:
Alexander M Price, Robert T Steinbock, Richard Lauman, Matthew Charman, Katharina E Hayer, Namrata Kumar, Edwin Halko, Krystal K Lum, Monica Wei, Angus C Wilson, Benjamin A Garcia, Daniel P Depledge, Matthew D Weitzman
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010797 (2022)
Adenovirus is a common human pathogen that relies on host cell processes for transcription and processing of viral RNA and protein production. Although adenoviral promoters, splice junctions, and polyadenylation sites have been characterized using lo
Externí odkaz:
https://doaj.org/article/eaab36792be84a51a07f2ccdca52cc19
Autor:
Shirley E Braspenning, Georges M G M Verjans, Tamana Mehraban, Ilhem Messaoudi, Daniel P Depledge, Werner J D Ouwendijk
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010084 (2021)
Primary infection with varicella-zoster virus (VZV) causes varicella and the establishment of lifelong latency in sensory ganglion neurons. In one-third of infected individuals VZV reactivates from latency to cause herpes zoster, often complicated by
Externí odkaz:
https://doaj.org/article/86449d0da5794dd39ce9a7f6db65290f
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008076 (2019)
During latent infections with herpes simplex virus 1 (HSV-1), viral transcription is restricted and the genomes are mostly maintained in silenced chromatin, whereas in lytically infected cells all viral genes are transcribed and the genomes are dynam
Externí odkaz:
https://doaj.org/article/629dba7c00794ceab8f998d5ad73acb9
Autor:
Carina Jacobsen, Nina Plückebaum, George Ssebyatika, Sarah Beyer, Lucas Mendes-Monteiro, Jiayi Wang, Kai A. Kropp, Víctor González-Motos, Lars Steinbrück, Birgit Ritter, Claudio Rodríguez-González, Heike Böning, Eirini Nikolouli, Paul R. Kinchington, Nico Lachmann, Daniel P. Depledge, Thomas Krey, Abel Viejo-Borbolla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract During primary varicella zoster virus (VZV) infection, infected lymphocytes drive primary viremia, causing systemic dissemination throughout the host, including the skin. This results in cytokine expression, including interferons (IFNs), whi
Externí odkaz:
https://doaj.org/article/0569487febc14ccf86b8f547b6011d69
Autor:
Charlotte Jane Houldcroft, Josephine M Bryant, Daniel P Depledge, Ben K Margetts, Jacob Simmonds, Stephanos Nicolaou, Helena J Tutill, Rachel Williams, Austen Worth, Stephen D Marks, Paul Veys, Elizabeth Whittaker, Judith Breuer
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Human cytomegalovirus (HCMV) is a significant pathogen in immunocompromised individuals, with the potential to cause fatal pneumonitis and colitis, as well as increasing the risk of organ rejection in transplant patients. With the advent of new anti-
Externí odkaz:
https://doaj.org/article/82bf7283fe104d67aa442243ed8f59ce
Autor:
Jonathan S. Abebe, Yasmine Alwie, Erik Fuhrmann, Jonas Leins, Julia Mai, Ruth Verstraten, Sabrina Schreiner, Angus C. Wilson, Daniel P. Depledge
Publikováno v:
mSystems, Vol 9, Iss 7 (2024)
ABSTRACT Nanopore direct RNA sequencing (DRS) enables the capture and full-length sequencing of native RNAs, without recoding or amplification bias. Resulting data sets may be interrogated to define the identity and location of chemically modified ri
Externí odkaz:
https://doaj.org/article/6e0769599e5e491b9ab29a7c043b7473
Autor:
Daniel P Depledge, Anne L Palser, Simon J Watson, Imogen Yi-Chun Lai, Eleanor R Gray, Paul Grant, Ravinder K Kanda, Emily Leproust, Paul Kellam, Judith Breuer
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27805 (2011)
Whole genome sequencing of viruses directly from clinical samples is integral for understanding the genetics of host-virus interactions. Here, we report the use of sample sparing target enrichment (by hybridisation) for viral nucleic acid separation
Externí odkaz:
https://doaj.org/article/4a2b7b05c6044185b798843507397a41
Autor:
Daniel P Depledge, Lorna M MacLean, Michael R Hodgkinson, Barbara A Smith, Andrew P Jackson, Saufung Ma, Silvia R B Uliana, Deborah F Smith
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 9, p e829 (2010)
A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania s
Externí odkaz:
https://doaj.org/article/4815e1e8ad404005aaca7d83494d9117
Autor:
Daniel P Depledge, Krystal J Evans, Alasdair C Ivens, Naveed Aziz, Asher Maroof, Paul M Kaye, Deborah F Smith
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 7, p e476 (2009)
Genome sequencing of Leishmania species that give rise to a range of disease phenotypes in the host has revealed highly conserved gene content and synteny across the genus. Only a small number of genes are differentially distributed between the three
Externí odkaz:
https://doaj.org/article/6a7f5da7ccb74d0f92a195ebd1b21106
Autor:
Tomohiko Sadaoka, Daniel P. Depledge, Labchan Rajbhandari, Judith Breuer, Arun Venkatesan, Jeffrey I. Cohen
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Attenuation of the live varicella Oka vaccine (vOka) has been attributed to mutations in the genome acquired during cell culture passage of pOka (parent strain); however, the precise mechanisms of attenuation remain unknown. Comparative sequ
Externí odkaz:
https://doaj.org/article/e7ad591c2f7a4c3b8122f3c04135c600