Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniel P Denning"'
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003341 (2013)
Caspases are cysteine proteases that can drive apoptosis in metazoans and have critical functions in the elimination of cells during development, the maintenance of tissue homeostasis, and responses to cellular damage. Although a growing body of rese
Externí odkaz:
https://doaj.org/article/0d1cadd217b14ebc81bda5b6b1307452
Autor:
V V Krishnan, Edmond Y Lau, Justin Yamada, Daniel P Denning, Samir S Patel, Michael E Colvin, Michael F Rexach
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 8, p e1000145 (2008)
The nuclear pore complex (NPC) provides the sole aqueous conduit for macromolecular exchange between the nucleus and the cytoplasm of cells. Its diffusion conduit contains a size-selective gate formed by a family of NPC proteins that feature large, n
Externí odkaz:
https://doaj.org/article/ceb5cd69ae3b4926bf29d2d110d8e741
Autor:
Carlos Pardo-Pastor, Daniel P. Denning, Nolan Tucker, Vivek K. Dwivedi, Rita Droste, Jody Rosenblatt, Ji Na Kong, H. Robert Horvitz
Publikováno v:
Nature. 593:591-596
Cell extrusion is a mechanism of cell elimination that is used by organisms as diverse as sponges, nematodes, insects and mammals1–3. During extrusion, a cell detaches from a layer of surrounding cells while maintaining the continuity of that layer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::741f4468070403165f39c16f275b5719
https://doi.org/10.1038/s41586-021-03526-y
https://doi.org/10.1038/s41586-021-03526-y
Autor:
Vivek K, Dwivedi, Carlos, Pardo-Pastor, Rita, Droste, Ji Na, Kong, Nolan, Tucker, Daniel P, Denning, Jody, Rosenblatt, H Robert, Horvitz
Publikováno v:
Nature. 593(7860)
Cell extrusion is a mechanism of cell elimination that is used by organisms as diverse as sponges, nematodes, insects and mammals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5cb10278902a2af058e214f5f0168427
https://pubmed.ncbi.nlm.nih.gov/34002080
https://pubmed.ncbi.nlm.nih.gov/34002080
Publikováno v:
Nature
The elimination of unnecessary or defective cells from metazoans occurs during normal development and tissue homeostasis, as well as in response to infection or cellular damage. Although many cells are removed through caspase-mediated apoptosis follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcd719fe85587b4c46ad64cf48d259b
https://doi.org/10.1038/nature11240
https://doi.org/10.1038/nature11240
Autor:
Michael Rexach, Daniel P. Denning
Publikováno v:
Molecular & Cellular Proteomics. 6:272-282
Nucleoporins with phenylalanine-glycine repeats (FG Nups) function at the nuclear pore complex (NPC) to facilitate nucleocytoplasmic transport. In Saccharomyces cerevisiae, each FG Nup contains a large natively unfolded domain that is punctuated by F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789b1040679eaee64302ab8a8d74d371
https://doi.org/10.1074/mcp.m600309-mcp200
https://doi.org/10.1074/mcp.m600309-mcp200
Autor:
Bruce F. O'Hara, H. Craig Heller, Daniel P. Denning, Judith Flores, Robert M. Sapolsky, Norman F. Ruby, Ilana S. Hairston, Christelle Peyron
Publikováno v:
Journal of Neurophysiology. 91:1586-1595
The sleeping brain differs from the waking brain in its electrophysiological and molecular properties, including the expression of growth factors and immediate early genes (IEG). Sleep architecture and homeostatic regulation of sleep in neonates is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cb7ae9fdb2b1c31a0a7862b988a084
https://doi.org/10.1152/jn.00894.2003
https://doi.org/10.1152/jn.00894.2003
Publikováno v:
Journal of Biological Chemistry. 277:33447-33455
Little is known about the structure of the individual nucleoporins that form eukaryotic nuclear pore complexes (NPCs). We report here in vitro physical and structural characterizations of a full-length nucleoporin, the Saccharomyces cerevisiae protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac367196ccf2c8afd6796761b3cd91e
https://doi.org/10.1074/jbc.m203499200
https://doi.org/10.1074/jbc.m203499200
Autor:
Takashi Hirose, Daniel P. Denning
Publikováno v:
Nature cell biology. 16(8)
Anti-tubulin drugs are life-saving chemotherapeutics that kill cancer cells by stabilizing or disrupting microtubules. Despite their clinical utility, the molecular mechanisms by which anti-tubulins cause apoptotic cell death remain poorly understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdae6fb3ad948a424d9005099f791321
https://pubmed.ncbi.nlm.nih.gov/25064737
https://pubmed.ncbi.nlm.nih.gov/25064737
A classic feature of apoptotic cells is the cell-surface exposure of phosphatidylserine (PtdSer) as an "eat me" signal for engulfment. We show that the Xk-family protein Xkr8 mediates PtdSer exposure in response to apoptotic stimuli. Mouse Xkr8(-/-)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a552dd5f097a4864791590c30eb32bf
https://zenodo.org/record/895627
https://zenodo.org/record/895627
