Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Daniel P, Downes"'
Autor:
Santhosh Satapati, Daniel P. Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Yingjiang Zhou, Zhao Ren, Michelle Chen, Yeon-Hee Lim, Nathan G. Hatcher, Xiujuan Wen, Payal R. Sheth, David G. McLaren, Stephen F. Previs
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 20-28 (2022)
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions. A
Externí odkaz:
https://doaj.org/article/103ba40a3e5a45859c5af8ed7bf87a21
Autor:
Wendy Zhong, David G. McLaren, Daniel Metzger, Ji Zhang, Daniel P. Downes, Payal R. Sheth, Saswata Talukdar, Julie Lao, Guillermo Godinez, Santhosh Satapati, Stephen F. Previs, Bingming Chen
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:2421-2425
Spatial characterization of triglyceride metabolism is an area of significant interest which can be enabled by mass spectrometry imaging via recent advances in neutral lipid laser desorption analytical approaches. Here, we extend recent advancements
Autor:
Bao Jen Shyong, David G. McLaren, Maria Webb, Joel Mane, Stephen F. Previs, Haihong Zhou, David E. Kelley, Carlos G. Rodriguez, Kevin P. Bateman, Yichen Wang, Daniel P. Downes, Natalie A. Daurio, George H. Addona, Andrea K. Houghton, Ying Chen, Peter Zafian, Ester Carballo-Jane, Rena Zhang
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 316:E1105-E1117
The regulation of nutrient homeostasis, i.e., the ability to transition between fasted and fed states, is fundamental in maintaining health. Since food is typically consumed over limited (anabolic) periods, dietary components must be processed and st
Autor:
Daniel P, Downes, Takhar, Kasumov, Natalie A, Daurio, Neil B, Wood, Michael J, Previs, Payal R, Sheth, David G, McLaren, Stephen F, Previs
Publikováno v:
Metabolites
Stable isotope tracers can be used to quantify the activity of metabolic pathways. Specifically, 2H-water is quite versatile, and its incorporation into various products can enable measurements of carbohydrate, lipid, protein and nucleic acid kinetic
Autor:
Daniel P. Downes
Publikováno v:
Chembiochem : a European journal of chemical biology. 22(4)
In order to achieve patient personalization and translate compounds through the discovery phase into the clinic, high throughput test models should be designed to be as closely matched to the patient as possible. Engineering high throughput and physi
Autor:
Stephen F. Previs, Natalie A. Daurio, Katharine Brown Williams, Paul E. Carrington, Daniel P. Downes, David G. McLaren
Publikováno v:
ACS chemical biology. 15(7)
Lipid oxidation and biosynthesis are crucial for cell survival, especially for rapidly proliferating cancer cells in a heterogeneous metabolic environment. The storage of high-energy lipid reservoirs competitively advantages the cancer cell over non-
Autor:
Stephen F, Previs, Daniel P, Downes
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2104
"Omics"-based analyses are widely used in numerous areas of research, advances in instrumentation (both hardware and software) allow investigators to collect a wealth of data and therein characterize metabolic systems. Although analyses generally exa
Autor:
Daniel P. Downes, Stephen F. Previs
Publikováno v:
Computational Methods and Data Analysis for Metabolomics ISBN: 9781071602386
"Omics"-based analyses are widely used in numerous areas of research, advances in instrumentation (both hardware and software) allow investigators to collect a wealth of data and therein characterize metabolic systems. Although analyses generally exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6625d95be2f1dd7bdc6cac74eae13485
https://doi.org/10.1007/978-1-0716-0239-3_6
https://doi.org/10.1007/978-1-0716-0239-3_6
Publikováno v:
NMR in Biomedicine. 29:226-231
The hyperpolarization of metabolic substrates at low temperature using dynamic nuclear polarization (DNP), followed by rapid dissolution and injection into an MRSI or NMR system, allows in vitro or in vivo observation and tracking of biochemical reac
Autor:
Keith A. Michel, James A. Bankson, Alan Carter, Anthony G. Giacalone, Marc McLeod, Daniel P. Downes, Matthew E. Merritt, Mukundan Ragavan
Publikováno v:
The FASEB Journal. 34:1-1