Výsledky vyhledávání - "Daniel Oreper"

Akademický článek

Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve MSS-CRC patient outcomes. Here, we demonstrate that high t

Externí odkaz: https://doaj.org/article/60a294e8ef9e4b37a641c0c3e8919afe

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Akademický článek

Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity

Autor: Judit Svensson-Arvelund, Sara Cuadrado-Castano, Gvantsa Pantsulaia, Kristy Kim, Mark Aleynick, Linda Hammerich, Ranjan Upadhyay, Michael Yellin, Henry Marsh, Daniel Oreper, Suchit Jhunjhunwala, Christine Moussion, Miriam Merad, Brian D. Brown, Adolfo García-Sastre, Joshua D. Brody

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Strategies to advance T cell based immune therapies are mostly focusing on the improvement of CD8 T cell effector functions, such as cytotoxicity or recruitment to the tumor. Here authors show that by combining in situ vaccination with oncolytic Newc

Externí odkaz: https://doaj.org/article/d4dc7bf6f3c1411dac7c7248c9250073

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Akademický článek

Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming

Autor: Michael Yellin, Miriam Merad, Henry Marsh, Ranjan Upadhyay, Judit Svensson-Arvelund, Daniel Oreper, Mark Aleynick, Gvantsa Pantsulaia, Kristy Kim, Samuel A Rose, Suchit Jhunjhunwala, Christine Carine Moussion, Brian D Brown, Joshua D Brody

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 7 (2023)

Background Cancer immunotherapies are generally effective in patients whose tumors contain a priori primed T-cells reactive to tumor antigens (TA). One approach to prime TA-reactive T-cells is to administer immunostimulatory molecules, cells, or path

Externí odkaz: https://doaj.org/article/af511e4b189e4272917485ed9ec6c48a

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Akademický článek

Reciprocal F1 Hybrids of Two Inbred Mouse Strains Reveal Parent-of-Origin and Perinatal Diet Effects on Behavior and Expression

Autor: Daniel Oreper, Sarah A. Schoenrock, Rachel McMullan, Robin Ervin, Joseph Farrington, Darla R. Miller, Fernando Pardo-Manuel de Villena, William Valdar, Lisa M. Tarantino

Publikováno v: G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3447-3468 (2018)

Parent-of-origin effects (POE) in mammals typically arise from maternal effects or imprinting. In some instances, such POE have been associated with psychiatric disorders, as well as with changes in a handful of animal behaviors. However, POE on comp

Externí odkaz: https://doaj.org/article/6d0c9a26e8da4ba9a819777eddd5ed59

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Akademický článek

Inbred Strain Variant Database (ISVdb): A Repository for Probabilistically Informed Sequence Differences Among the Collaborative Cross Strains and Their Founders

Autor: Daniel Oreper, Yanwei Cai, Lisa M. Tarantino, Fernando Pardo-Manuel de Villena, William Valdar

Publikováno v: G3: Genes, Genomes, Genetics, Vol 7, Iss 6, Pp 1623-1630 (2017)

The Collaborative Cross (CC) is a panel of recently established multiparental recombinant inbred mouse strains. For the CC, as for any multiparental population (MPP), effective experimental design and analysis benefit from detailed knowledge of the g

Externí odkaz: https://doaj.org/article/3d5cf3876d4049ee8afbedcda80a3a37

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Data from Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma

Autor: Maxwell V. Meng, Oliver A. Zill, Ximo Pechuan-Jorge, Charles Havnar, Nicolas Lounsbury, Daniel Oreper, Amy A. Lo, Sima P. Porten, Andrew Wallace

Renal cell carcinoma (RCC) with venous tumor thrombus (VTT) arising from the primary tumor occurs in approximately 10% of cases and is thought to represent more advanced disease. The intravascular nature of VTT suggests that it may serve as a source

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdbab156a135784664fac7fb17a983d
https://doi.org/10.1158/1541-7786.c.6545606

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