Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Daniel Offen"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2013-2019 (2022)
The CRISPR-Cas system has transformed the field of gene-editing and created opportunities for novel genome engineering therapeutics. The field has significantly progressed, and recently, CRISPR-Cas9 was utilized in clinical trials to target disease-c
Externí odkaz:
https://doaj.org/article/fb1e926087484f31873e97e8d29b76b4
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disease with a wide spectrum of manifestation. The core symptoms of ASD are persistent deficits in social communication, and restricted and repetitive patterns of behavior, interests, or
Externí odkaz:
https://doaj.org/article/e018d76321c748c3bebd513677db3bcf
Autor:
Hadas Tsivion-Visbord, Eli Kopel, Ariel Feiglin, Tamar Sofer, Ran Barzilay, Tali Ben-Zur, Orly Yaron, Daniel Offen, Erez Y. Levanon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Interferon can be induced by the viral mimic PolyI:C, which can in turn activate RNA editing enzymes. Here the authors identify transient changes in A-to-I RNA editing following maternal immune activation in mice.
Externí odkaz:
https://doaj.org/article/2ed2b8422be94f928e72f7b89c81639b
Autor:
Reut Guy, Shay Herman, Hadar Benyamini, Tali Ben-Zur, Hila Kobo, Metsada Pasmanik-Chor, Dafna Yaacobi, Eric Barel, Chana Yagil, Yoram Yagil, Daniel Offen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11211 (2022)
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been employed in the past decade as therapeutic agents in various diseases, including central nervous system (CNS) disorders. We currently aimed to use MSC-EVs as potential treatment
Externí odkaz:
https://doaj.org/article/97e80c98ab19414880e31b7a3d7b6d8b
Autor:
Reut Guy, Rotem Volkman, Ella Wilczynski, Chana Yagil, Yoram Yagil, Michael Findler, Eitan Auriel, Uri Nevo, Daniel Offen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5915 (2022)
Cerebral small vessel disease (CSVD) is the second most common cause of stroke and a major contributor to dementia. Manifestations of CSVD include cerebral microbleeds, intracerebral hemorrhages (ICH), lacunar infarcts, white matter hyperintensities
Externí odkaz:
https://doaj.org/article/7660c04732094f67b93b180b1f39425a
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-12 (2018)
Abstract Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by three core symptoms that include social interaction deficits, cognitive inflexibility, and communication disorders. They have been steadily increasing in child
Externí odkaz:
https://doaj.org/article/b92d3f0f85084e49a1e70aa6a551982e
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Clustered regularly interspaced short palindromic repeats (CRISPR) is a promising novel technology that holds the potential of treating genetic diseases. Safety and specificity of the treatment are to be further studied and developed prior to impleme
Externí odkaz:
https://doaj.org/article/a8322bf3e4ec4e7d9bba1b018fd95fda
Autor:
Shaowei Guo, Oshra Betzer, Nisim Perets, Shira Landau, Daniel Offen, Rachela Popovtzer, shulamit Levenberg
Publikováno v:
Bio-Protocol, Vol 10, Iss 11 (2020)
Exosomes, a subtype of extracellular vesicles, are nanovesicles of endocytic origin. Exosomes contain a plethora of proteins, lipids, and genetic materials of parent cells to facilitate intercellular communications. Tracking exosomes in vivo is funda
Externí odkaz:
https://doaj.org/article/5bc672217f59448eb4b624490e66ec46
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Myeloperoxidase (MPO) is an enzyme expressed mostly by neutrophils and is a primary mediator of neutrophils oxidative stress response. While a profound body of evidence associates neutrophil-derived MPO in the pathogenesis of Alzheimer’s disease (A
Externí odkaz:
https://doaj.org/article/5131697eb5ee46629b02a9227b350eda
Autor:
Reut Guy, Frida Grynspan, Tali Ben-Zur, Avraham Panski, Ron Lamdan, Uri Danon, David Yaffe, Daniel Offen
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
The peripheral nervous system has an intrinsic ability to regenerate after injury. However, this process is slow, incomplete, and often accompanied by disturbing motor and sensory consequences. Sciatic nerve injury (SNI), which is the most common mod
Externí odkaz:
https://doaj.org/article/79bf9e71dd4e4a948a81d12d44ebab05