The protein family TcTASV-C is a novel Trypanosoma cruzi virulence factor secreted in extracellular vesicles by trypomastigotes and highly expressed in bloodstream forms.

Autor: Lucas D Caeiro, Catalina D Alba-Soto, Mariana Rizzi, María Elisa Solana, Giselle Rodriguez, Agustina M Chidichimo, Matías E Rodriguez, Daniel O Sánchez, Gabriela V Levy, Valeria Tekiel

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006475 (2018)

TcTASV-C is a protein family of about 15 members that is expressed only in the trypomastigote stage of Trypanosoma cruzi. We have previously shown that TcTASV-C is located at the parasite surface and secreted to the medium. Here we report that the ex

Externí odkaz: https://doaj.org/article/4bfeedf61f5941e1813cfd719800cd43

TcTASV-C, a protein family in Trypanosoma cruzi that is predominantly trypomastigote-stage specific and secreted to the medium.

Autor: Guillermo Bernabó, Gabriela Levy, María Ziliani, Lucas D Caeiro, Daniel O Sánchez, Valeria Tekiel

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e71192 (2013)

Among the several multigene families codified by the genome of T. cruzi, the TcTASV family was the latest discovered. The TcTASV (Trypomastigote, Alanine, Serine, Valine) family is composed of ∼40 members, with conserved carboxi- and amino-termini

Externí odkaz: https://doaj.org/article/9b57a987c52b4c7d8b42d1dc4d370b45

Nucleolar localization of RNA binding proteins induced by actinomycin D and heat shock in Trypanosoma cruzi.

Autor: Ezequiel Názer, Ramiro E Verdún, Daniel O Sánchez

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19920 (2011)

In this work we show that under Actinomycin D (ActD) treatment, several RNA Binding Proteins (RBPs) involved in mRNA metabolism are relocalized into the nucleolus in Trypanosoma cruzi as a specific stress response. ATP depletion as well as kinase inh

Externí odkaz: https://doaj.org/article/ecd2b8c4ad4b452aae1cfd68d689c926

TcTASV: a novel protein family in trypanosoma cruzi identified from a subtractive trypomastigote cDNA library.

Autor: Elizabeth A García, María Ziliani, Fernán Agüero, Guillermo Bernabó, Daniel O Sánchez, Valeria Tekiel

Publikováno v: PLoS Neglected Tropical Diseases, Vol 4, Iss 10, p e1000938 (2010)

BACKGROUND: The identification and characterization of antigens expressed in Trypanosoma cruzi stages that parasitize mammals are essential steps for the development of new vaccines and diagnostics. Genes that are preferentially expressed in trypomas

Externí odkaz: https://doaj.org/article/f1f051e51039461c8a06bbb6d79aaca0

FastqCleaner: an interactive Bioconductor application for quality-control, filtering and trimming of FASTQ files

Autor: Leandro G Roser, Fernán Agüero, Daniel O. Sánchez

Publikováno v: BMC Bioinformatics, Vol 20, Iss 1, Pp 1-7 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
BMC Bioinformatics

Background Exploration and processing of FASTQ files are the first steps in state-of-the-art data analysis workflows of Next Generation Sequencing (NGS) platforms. The large amount of data generated by these technologies has put a challenge in terms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0102e0afdded5fe4c805ee8d9628af6b
http://link.springer.com/article/10.1186/s12859-019-2961-8