Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Daniel Normolle"'
Autor:
John J. Skoko, Juxiang Cao, David Gaboriau, Myriam Attar, Alparslan Asan, Lisa Hong, Candice E. Paulsen, Hongqiang Ma, Yang Liu, Hanzhi Wu, Trey Harkness, Cristina M. Furdui, Yefim Manevich, Ciaran G. Morrison, Erika T. Brown, Daniel Normolle, Maria Spies, Michael Ashley Spies, Kate Carroll, Carola A. Neumann
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102443- (2022)
RAD51 is a critical recombinase that functions in concert with auxiliary mediator proteins to direct the homologous recombination (HR) DNA repair pathway. We show that Cys319 RAD51 possesses nucleophilic characteristics and is important for irradiati
Externí odkaz:
https://doaj.org/article/2fc66d80d6fa4b56ae9f41a240a26b8a
Autor:
Lan G. Coffman, Taylor J. Orellana, Tianshi Liu, Leonard G. Frisbie, Daniel Normolle, Kent Griffith, Shitanshu Uppal, Karen McLean, Jessica Berger, Michelle Boisen, Madeleine Courtney-Brooks, Robert P. Edwards, Jamie Lesnock, Haider Mahdi, Alexander Olawaiye, Paniti Sukumvanich, Sarah E. Taylor, Ronald Buckanovich
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
BACKGROUND New therapeutic combinations to improve outcomes of patients with ovarian cancer are clearly needed. Preclinical studies with ribociclib (LEE-011), a CDK4/6 cell cycle checkpoint inhibitor, demonstrate a synergistic effect with platinum ch
Externí odkaz:
https://doaj.org/article/0e91eac13b934298960720568bddbce7
Autor:
Greg M Delgoffe, Kristin DePeaux, Angen Liu, Dan P Zandberg, Ashley V Menk, Maria Velez, Daniel Normolle
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
The majority of patients with recurrent/metastatic squamous cell carcinoma of the head and neck (HNSCC) (R/M) do not benefit from anti-PD-1 therapy. Hypoxia induced immunosuppression may be a barrier to immunotherapy. Therefore, we examined the metab
Externí odkaz:
https://doaj.org/article/d0916971c66149a6a4ea79c16d0bb5d0
Autor:
Aron Popovtzer, Daniel Normolle, Francis P. Worden, Mark E. Prince, Douglas B. Chepeha, Gregory T. Wolf, Carol R. Bradford, Theodore S. Lawrence, Avraham Eisbruch
Publikováno v:
Translational Oncology, Vol 7, Iss 4, Pp 479-483 (2014)
BACKGROUND: Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantia
Externí odkaz:
https://doaj.org/article/771349b770c24917a971c2cd1c6a87e2
Autor:
Lindsay R Dresang, Anna Guastafierro, Reety Arora, Daniel Normolle, Yuan Chang, Patrick S Moore
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80543 (2013)
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with high mortality. Merkel cell polyomavirus (MCV), discovered in 2008, is associated with ~80% of MCC. The MCV large tumor (LT) oncoprotein upregulates the cellular oncoprotein
Externí odkaz:
https://doaj.org/article/e7909d6eac544daa993c3a34efd7e948
Autor:
Muhamuda Kader, Amanda P Smith, Cristiana Guiducci, Elizabeth R Wonderlich, Daniel Normolle, Simon C Watkins, Franck J Barrat, Simon M Barratt-Boyes
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003530 (2013)
Persistent production of type I interferon (IFN) by activated plasmacytoid dendritic cells (pDC) is a leading model to explain chronic immune activation in human immunodeficiency virus (HIV) infection but direct evidence for this is lacking. We used
Externí odkaz:
https://doaj.org/article/33f72c1a3e8c4c0ea5e08ced56000ba3
Publikováno v:
Cancer Informatics, Vol 1 (2005)
The design of early-phase studies of putative screening markers in clinical populations is discussed. Biological, epidemiological, statistical and computational issues all affect the design of early-phase studies of these markers, but there are frequ
Externí odkaz:
https://doaj.org/article/5e7d0230ff9442efa5e4534908c3763e
Autor:
Daniel Normolle, Theodore S. Lawrence, Jonathan Maybaum, Leslie A. Parsels, Meredith A. Morgan, Lili Zhao
CCR Translation for This Article from Bayesian Hierarchical Changepoint Methods in Modeling the Tumor Growth Profiles in Xenograft Experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74c79c0ec2b81720f75e64092f12742
https://doi.org/10.1158/1078-0432.22444494.v1
https://doi.org/10.1158/1078-0432.22444494.v1
Autor:
Daniel Normolle, Theodore S. Lawrence, Jonathan Maybaum, Leslie A. Parsels, Meredith A. Morgan, Lili Zhao
Purpose: The standard approach of using tumor doubling time to assess growth delay may not accurately represent tumor response, especially if the growth rates are not constant. Therefore, we developed a method to compare the antitumor activities of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17be93dc30c5401a790ee3fcb9f481ec
https://doi.org/10.1158/1078-0432.c.6520200.v1
https://doi.org/10.1158/1078-0432.c.6520200.v1
Autor:
Pawel Kalinski, David L. Bartlett, Todd A. Reinhart, The Minh Luong, Daniel Normolle, Amer H. Zureikat, Herbert J. Zeh, Beth Fallert Junecko, Erik Berk, Ravikumar Muthuswamy
PDF file - 191K, Processing of tumors and marginal tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0465eba245ee43b14a1043e44452af62
https://doi.org/10.1158/0008-5472.22393811.v1
https://doi.org/10.1158/0008-5472.22393811.v1