Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel N. Weinberg"'
Autor:
Douglas Barrows, Matthew R. Marunde, C. David Allis, Xiao Chen, Cynthia Horth, Phillip Rosenbaum, Michael-Christopher Keogh, Daniel N. Weinberg, Irina K. Popova, Chao Lu, Jacek Majewski, Zachary B. Gillespie
Publikováno v:
Nat Genet
Precise deposition of CpG methylation is critical for mammalian development and tissue homeostasis and is often dysregulated in human diseases. The localization of de novo DNA methyltransferase DNMT3A is facilitated by its PWWP domain recognizing his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a78d76b60034f02c0ddcd6a8fa163a
https://doi.org/10.1038/s41588-021-00856-5
https://doi.org/10.1038/s41588-021-00856-5
Autor:
Haifen Chen, Bo Hu, Cynthia Horth, Eric Bareke, Phillip Rosenbaum, Sin Young Kwon, Jacinthe Sirois, Daniel N. Weinberg, Faith M. Robison, Benjamin A. Garcia, Chao Lu, William A. Pastor, Jacek Majewski
Publikováno v:
Genome Research.
Epigenetic modifications on the chromatin do not occur in isolation. Chromatin-associated proteins and their modification products form a highly interconnected network, and disturbing one component may rearrange the entire system. We see this increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d5962eaa75e7cd889a0fa02e73555e
https://doi.org/10.1101/gr.276383.121
https://doi.org/10.1101/gr.276383.121
Autor:
Marcus A. Cheek, Michael-Christopher Keogh, John T. McGuire, Matthew R. Marunde, Daniel N. Weinberg, Simon Papillon-Cavanagh, Kartik N. Rajagopalan, Chao Lu, Haitao Li, Nada Jabado, Jacek Majewski, Yuan Yue, Anissa Djedid, Eric Bareke, Xinjing Xu, Ashot S. Harutyunyan, Xiao Chen, Agata E. Lemiesz, Cynthia Horth, Hamid Nikbakht, Matthew J. Meiners, Haifen Chen, Dylan M. Marchione, Benjamin A. Garcia, C. David Allis
Publikováno v:
Nature
Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue development and homeostasis1–4. They are also implicated in human developmental disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b7b3bb455ad9ea34b53418c766330d
https://doi.org/10.1038/s41586-019-1534-3
https://doi.org/10.1038/s41586-019-1534-3
Autor:
C. David Allis, Daniel N. Weinberg, Xiao Chen, Haifen Chen, Kartik N. Rajagopalan, Chao Lu, Jacek Majewski
Publikováno v:
Proc Natl Acad Sci U S A
Hotspot histone H3 mutations have emerged as drivers of oncogenesis in cancers of multiple lineages. Specifically, H3 lysine 36 to methionine (H3K36M) mutations are recurrently identified in chondroblastomas, undifferentiated sarcomas, and head and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0abeb08938c8ead63e5500c447376b
https://europepmc.org/articles/PMC7936350/
https://europepmc.org/articles/PMC7936350/
Autor:
C. David Allis, Dylan M. Marchione, Shriya Deshmukh, Chao Lu, Nada Jabado, Benjamin A. Garcia, Siddhant U. Jain, Daniel N. Weinberg, Sima Khazaei, Nikoleta Juretic, Stefan M. Lundgren, Xiaoshi Wang, Peter W. Lewis
Publikováno v:
Proc Natl Acad Sci U S A
A high percentage of pediatric gliomas and bone tumors reportedly harbor missense mutations at glycine 34 in genes encoding histone variant H3.3. We find that these H3.3 G34 mutations directly alter the enhancer chromatin landscape of mesenchymal ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8d633a64134f754090936564162036
https://europepmc.org/articles/PMC7959516/
https://europepmc.org/articles/PMC7959516/
Autor:
Tom W. Muir, Katharine L. Diehl, Krupa S. Jani, Eva J. Ge, C. David Allis, Daniel N. Weinberg
A lysine-to-methionine mutation at lysine 27 of histone 3 (H3K27M) has been shown to promote oncogenesis in a subset of pediatric gliomas. While there is evidence that this "oncohistone" mutation acts by inhibiting the histone methyltransferase PRC2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b031144d160f4f9ede8774576c5227
https://europepmc.org/articles/PMC6825254/
https://europepmc.org/articles/PMC6825254/
Autor:
Jolanta Grembecka, Daniel N. Weinberg, Sally A. Camper, Ann Friedman, Tomasz Cierpicki, Jing Xu, Julien Schira, Michelle L. Brinkmeier, Yali Dou, Sami N. Malek, Morgan Jones, Ivan Maillard, Jennifer Chase
Publikováno v:
Journal of Clinical Investigation. 125:2007-2020
Rapidly cycling fetal and neonatal hematopoietic stem cells (HSCs) generate a pool of quiescent adult HSCs after establishing hematopoiesis in the bone marrow. We report an essential role for the trithorax group gene absent, small, or homeotic 1-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3421ea768133d2b83bfeaa444d6ca176
https://doi.org/10.1172/jci78124
https://doi.org/10.1172/jci78124
Publikováno v:
Cold Spring Harbor perspectives in medicine. 7(1)
Recurrent missense mutations in histone H3 were recently reported in pediatric gliomas and soft tissue tumors. Strikingly, these mutations only affected a minority of the total cellular H3 proteins and occurred at or near lysine residues at positions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f4a74b22e6f8c333d4039cfbde3e07
https://pubmed.ncbi.nlm.nih.gov/27864305
https://pubmed.ncbi.nlm.nih.gov/27864305
Autor:
Gail A. Osawa, Ann Friedman, Ivan Maillard, Joshua A. Regal, Hande Kocak, Morgan Jones, James Taggart, Catherine E. Keegan, David O. Ferguson, Daniel N. Weinberg
Publikováno v:
The Journal of clinical investigation. 124(1)
The shelterin complex plays dual functions in telomere homeostasis by recruiting telomerase and preventing the activation of a DNA damage response at telomeric ends. Somatic stem cells require telomerase activity, as evidenced by progressive stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f63bd43189a96fa2b894205b1320a8
https://pubmed.ncbi.nlm.nih.gov/24316971
https://pubmed.ncbi.nlm.nih.gov/24316971
Autor:
Elena Piskounova, Timothy M. Johnson, Douglas R. Fullen, Ugur Eskiocak, Mark Shackleton, Sean J. Morrison, Elsa Quintana, Daniel N. Weinberg
Publikováno v:
Science Translational Medicine. 4
Studies of human cancer metastasis have been limited by a lack of experimental assays in which cancer cells from patients metastasize in vivo in a way that correlates with clinical outcome. This makes it impossible to study intrinsic differences in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497db61d2e2190627664295a237330ae
https://doi.org/10.1126/scitranslmed.3004599
https://doi.org/10.1126/scitranslmed.3004599