Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daniel N. Mitroi"'
Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
Autor:
Ana Toledano-Zaragoza, Violeta Enriquez-Zarralanga, Sara Naya-Forcano, Víctor Briz, Rocío Alfaro-Ruíz, Miguel Parra-Martínez, Daniel N. Mitroi, Rafael Luján, José A. Esteban, María Dolores Ledesma
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-13 (2024)
Abstract Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations. Using an NPC mouse model (Npc1nmf164) we show aberrant
Externí odkaz:
https://doaj.org/article/a29dff6528f64981ad437746890a57a7
Autor:
Stefania Gheorghe, Miruna S. Stan, Daniel N. Mitroi, Andrea C. Staicu, Marius Cicirma, Irina E. Lucaciu, Mihai Nita-Lazar, Anca Dinischiotu
Publikováno v:
Toxics, Vol 10, Iss 5, p 227 (2022)
One cationic surfactant with a wide spectrum of microbiocidal activity is benzethonium chloride (BEC). Despite being widely used, the toxicity data on vertebrate organisms are limited. Therefore, we aimed to evaluate within this study the acute toxic
Externí odkaz:
https://doaj.org/article/113f61c1cd564a3f8fd40ed3cbaca963
Autor:
Stefania Gheorghe, Daniel N. Mitroi, Miruna S. Stan, Cristina A. Staicu, Marius Cicirma, Irina E. Lucaciu, Mihai Nita-Lazar, Anca Dinischiotu
Publikováno v:
Applied Sciences, Vol 10, Iss 23, p 8485 (2020)
Benzenthonium chloride (BEC, Hyamine 1622) is a quaternary ammonium surfactant with cationic properties widely used in cleaning, sanitation, and medical products that can become harmful to humans and also to the environment. This study aimed to evalu
Externí odkaz:
https://doaj.org/article/d2e9f0aca56b4c71a3b45ed8fcc136dd
Publikováno v:
Journal of cellular and molecular medicine. 26(11)
Vascular dementia (VaD) is the accumulation of vascular lesions in the subcortical white matter of the brain. These lesions progress and there is no direct medical therapy.To determine the specific cellular responses in VaD so as to provide molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a8d82c39668a481ed2d207136a543
https://pubmed.ncbi.nlm.nih.gov/35543222
https://pubmed.ncbi.nlm.nih.gov/35543222
Autor:
Liubov S Kalinichenko, Christiane Mühle, Tianye Jia, Felix Anderheiden, Maria Datz, Anna-Lisa Eberle, Volker Eulenburg, Jonas Granzow, Martin Hofer, Julia Hohenschild, Sabine E Huber, Stefanie Kämpf, Georgios Kogias, Laura Lacatusu, Charlotte Lugmair, Stephen Mbu Taku, Doris Meixner, Nina-Kristin Sembritzki, Marc Praetner, Cosima Rhein, Christina Sauer, Jessica Scholz, Franziska Ulrich, Florian Valenta, Esther Weigand, Markus Werner, Nicole Tay, Conor J Mc Veigh, Jana Haase, An-Li Wang, Laila Abdel-Hafiz, Joseph P Huston, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Anbarasu Lourdusamy, Philipp Kirchner, Arif B Ekici, Lena M Marx, Neeraja Puliparambil Suresh, Renato Frischknecht, Anna Fejtova, Essa M Saied, Christoph Arenz, Aline Bozec, Isabel Wank, Silke Kreitz, Andreas Hess, Tobias Bäuerle, Maria Dolores Ledesma, Daniel N Mitroi, André M Miranda, Tiago Gil Oliveira, Bernd Lenz, Gunter Schumann, Johannes Kornhuber, Christian P Müller
Alcohol use, abuse, and addiction, and resulting health hazards are highly sex-dependent with unknown mechanisms. Previously, strong links between the SMPD3 gene and its coded protein neutral sphingomyelinase 2 (NSM) and alcohol abuse, emotional beha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13748864840cee5ea7233fca00999c7
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/98785
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/98785
Autor:
Christina Sauer, André Miguel Lopes Miranda, Anna Fejtova, Doris Meixner, Christiane Mühle, Aline Bozec, Nina Tesch, Georgios Kogias, Christian P. Müller, Bernd Lenz, Daniel N Mitroi, Julia Hohenschild, Irena Smaga, Christoph Arenz, Jana Haase, Felix Anderheiden, Renato Frischknecht, Anbarasu Lourdusamy, Sabine E. Huber, Laila Abdel-Hafiz, Małgorzata Frankowska, Tianye Jia, Nicole Tay, An-Li Wang, Charlotte Lugmair, Gunter Schumann, Neeraja Puliparambil Suresh, Cosima Rhein, Lena M. Marx, Anna-Lisa Eberle, Essa M. Saied, Volker Eulenburg, Esther Weigand, Marc Praetner, Erich Gulbins, Martin Hofer, Laura Lacatusu, Jessica Scholz, Florian Valenta, Stefanie Kämpf, Philipp Kirchner, Arif B. Ekici, Conor J Mc Veigh, Tobias Bäuerle, Johannes Kornhuber, Franziska Ulrich, Silke Kreitz, Maria Dolores Ledesma, Isabel Wank, Jonas Granzow, Joseph P. Huston, Markus Werner, Tiago Gil Oliveira, Maria Datz, Andreas Hess, Małgorzata Filip, Stephen Mbu Taku, Liubov S. Kalinichenko
Publikováno v:
Molecular psychiatry. 26(12)
Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c58336856d28961edbae9a38cef91a6
https://pubmed.ncbi.nlm.nih.gov/34584229
https://pubmed.ncbi.nlm.nih.gov/34584229
Autor:
Miruna Silvia Stan, Marius Cicirma, Anca Dinischiotu, Daniel N. Mitroi, Mihai Nita-Lazar, Cristina A. Staicu, Irina Lucaciu, Stefania Gheorghe
Publikováno v:
Applied Sciences
Volume 10
Issue 23
Applied Sciences, Vol 10, Iss 8485, p 8485 (2020)
Volume 10
Issue 23
Applied Sciences, Vol 10, Iss 8485, p 8485 (2020)
Benzenthonium chloride (BEC, Hyamine 1622) is a quaternary ammonium surfactant with cationic properties widely used in cleaning, sanitation, and medical products that can become harmful to humans and also to the environment. This study aimed to evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e624c33b1f612e6b4e1038e46a18c1f
Autor:
Beatriz Soto-Huelin, Guadalupe Pereyra-Gómez, Maria Dolores Ledesma, José A. Esteban, Fernando Senovilla, Daniel N Mitroi, Toshihide Kobayashi
Publikováno v:
EMBO Reports
NPC is a neurodegenerative disorder characterized by cholesterol accumulation in endolysosomal compartments. It is caused by mutations in the gene encoding NPC1, an endolysosomal protein mediating intracellular cholesterol trafficking. Cognitive and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee3601d76d0c3b0ab04ccfff8c60cf
https://doi.org/10.15252/embr.201948143
https://doi.org/10.15252/embr.201948143
Autor:
Beatriz Soto-Huelin, Azucena Pérez-Cañamás, Héctor Peinado, César Venero, Daniel N Mitroi, Sara Sánchez-Redondo, Maria Dolores Ledesma, Enrique Gabandé-Rodríguez, Elena Martínez-Sáez
Publikováno v:
The EMBO Journal. 38
Neuropathic lysosomal storage disorders (LSDs) present with activated pro‐inflammatory microglia. However, anti‐inflammatory treatment failed to improve disease pathology. We characterise the mechanisms underlying microglia activation in Niemann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6d69b1bc7ef27d65ea7bdb00fc6350
https://doi.org/10.15252/embj.201899553
https://doi.org/10.15252/embj.201899553
Autor:
Indulekha Karunakaran, Maria Dolores Ledesma, Gerhild van Echten-Deckert, Daniel N. Mitroi, Dan Ehninger, Markus H. Gräler, Julie D. Saba
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Autophagy
Autophagy 13(5), 885-899 (2017). doi:10.1080/15548627.2017.1291471
Consejería de Sanidad de la Comunidad de Madrid
Autophagy
Autophagy 13(5), 885-899 (2017). doi:10.1080/15548627.2017.1291471
Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive signaling lipid sphingosine-1-phosphate (S1P) and its catabolic enzyme SGPL1/SPL (sphingos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07144b7ac8a525c32349e701a99e7ab