Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Daniel N. Itzhak"'
Autor:
Patrycja Kozik, Marine Gros, Daniel N. Itzhak, Leonel Joannas, Sandrine Heurtebise-Chrétien, Patrycja A. Krawczyk, Pablo Rodríguez-Silvestre, Andrés Alloatti, Joao Gamelas Magalhaes, Elaine Del Nery, Georg H.H. Borner, Sebastian Amigorena
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107905- (2020)
Summary: Cross-presentation of antigens by dendritic cells (DCs) is critical for initiation of anti-tumor immune responses. Yet, key steps involved in trafficking of antigens taken up by DCs remain incompletely understood. Here, we screen 700 US Food
Externí odkaz:
https://doaj.org/article/f41e73c206eb498a84df86376d83caea
Autor:
Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, Georg H. H. Borner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy thr
Externí odkaz:
https://doaj.org/article/ff52a2aa9d09459f8fa30ecd00dc3289
Autor:
Daniel N. Itzhak, Francesca Sacco, Nagarjuna Nagaraj, Stefka Tyanova, Matthias Mann, Marta Murgia
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 11 (2019)
The unfolded protein response (UPR) involves extensive proteome remodeling in many cellular compartments. To date, a comprehensive analysis of the UPR has not been possible because of technological limitations. Here, we employ stable isotope labeling
Externí odkaz:
https://doaj.org/article/ace79d21ea914797bb3163c1d71e5bf9
Autor:
Sophia Doll, Martina Dreßen, Philipp E. Geyer, Daniel N. Itzhak, Christian Braun, Stefanie A. Doppler, Florian Meier, Marcus-Andre Deutsch, Harald Lahm, Rüdiger Lange, Markus Krane, Matthias Mann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The human heart is composed of distinct regions and cell types, but relatively little is known about their specific protein composition. Here, the authors present a region- and cell type-specific proteomic map of the healthy human heart, revealing fu
Externí odkaz:
https://doaj.org/article/567eef510a6f43498199606e690bcfcb
Autor:
Daniel N. Itzhak, Colin Davies, Stefka Tyanova, Archana Mishra, James Williamson, Robin Antrobus, Jürgen Cox, Michael P. Weekes, Georg H.H. Borner
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2706-2718 (2017)
We previously developed a mass spectrometry-based method, dynamic organellar maps, for the determination of protein subcellular localization and identification of translocation events in comparative experiments. The use of metabolic labeling for quan
Externí odkaz:
https://doaj.org/article/4e7e1f1a20034d4da3e0f1464f66af92
Autor:
Matthew J Shurtleff, Daniel N Itzhak, Jeffrey A Hussmann, Nicole T Schirle Oakdale, Elizabeth A Costa, Martin Jonikas, Jimena Weibezahn, Katerina D Popova, Calvin H Jan, Pavel Sinitcyn, Shruthi S Vembar, Hilda Hernandez, Jürgen Cox, Alma L Burlingame, Jeffrey L Brodsky, Adam Frost, Georg HH Borner, Jonathan S Weissman
Publikováno v:
eLife, Vol 7 (2018)
The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane domains such as charged residues in ion channels are often functionally important, but coul
Externí odkaz:
https://doaj.org/article/4ca12fd255584f7abfe1d7b19016f4ea
Publikováno v:
PLoS Biology, Vol 16, Iss 1, p e2004411 (2018)
The AP-5 adaptor protein complex is presumed to function in membrane traffic, but so far nothing is known about its pathway or its cargo. We have used CRISPR-Cas9 to knock out the AP-5 ζ subunit gene, AP5Z1, in HeLa cells, and then analysed the phen
Externí odkaz:
https://doaj.org/article/0e289ba1d055410e916412195263730e
Autor:
Daniel N. Itzhak, Rahul S. Samant, Miranda P. Collier, Alma L. Burlingame, Karen Betancourt Moreira, Alexander Leitner, Judith Frydman, Yu-Chan Chen, Kathy H. Li
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
The eukaryotic chaperonin TRiC/CCT is a large ATP-dependent complex essential for cellular protein folding. Its subunit arrangement into two stacked eight-membered hetero-oligomeric rings is conserved from yeast to man. A recent breakthrough enables
Publikováno v:
eLife, Vol 5 (2016)
Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. We have developed and applied Dynamic Organellar Maps, a proteomic method that allows global mapping of protein
Externí odkaz:
https://doaj.org/article/ac1f19b68f134f2488a6c28c13017ecf
Autor:
Daniel N. Itzhak, Alexander P. Fields, Jonathan S. Weissman, Jin Chen, J. Zachery Cogan, James K. Nuñez, Andreas-David Brunner, Manuel D. Leonetti, Jason Y. Li, Britt Adamson, Matthias Mann
Publikováno v:
Science. 367:1140-1146
Expanding the human proteome Using mass spectrometry, ribosome profiling, and several CRISPR-based screens, Chen et al. identified hundreds of previously uncharacterized functional micropeptides in the human genome (see the Perspective by Wei and Guo