Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Daniel N. Clark"'
Publikováno v:
Viruses, Vol 15, Iss 1, p 107 (2022)
HIV/AIDS mortality has been decreasing over the last decade. While promising, this decrease correlated directly with increased use of antiretroviral drugs. As a natural consequence of its high mutation rate, treatments provide selection pressure that
Externí odkaz:
https://doaj.org/article/f1f315daa2cb4a6eba492603cd610009
Autor:
Timothy S. Buhlig, Anastasia F. Bowersox, Daniel L. Braun, Desiree N. Owsley, Kortney D. James, Alfredo J. Aranda, Connor D. Kendrick, Nicole A. Skalka, Daniel N. Clark
Publikováno v:
Viruses, Vol 12, Iss 5, p 570 (2020)
Approximately 250 million people are living with chronic hepatitis B virus (HBV) infections, which claim nearly a million lives annually. The target of all current HBV drug therapies (except interferon) is the viral polymerase; specifically, the reve
Externí odkaz:
https://doaj.org/article/6289ae2cf12f44d5bc2ce48a40693dd8
Autor:
Daniel N. Clark, R. Daniel Read, Vera eMayhew, Stephen C. Petersen, Lissenya B. Argueta, Lance A. Stutz, Rodney E. Till, Sean M. Bergsten, Brandon S. Robinson, Douglas G. Baumann, J. Casey Heap, Brian D. Poole
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Introduction: Autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis affect millions of people worldwide. Interferon regulatory factor 5 (IRF5) contains polymorphisms associated with these autoimmune dis
Externí odkaz:
https://doaj.org/article/ada1fc925dcf4bf9bcebc4199c070bac
Publikováno v:
The Enzymes. 50
Hepatitis B virus (HBV) is a hepatotropic, partially double-stranded DNA virus that replicates by reverse transcription and is a major cause of chronic liver disease and hepatocellular carcinoma. Reverse transcription is catalyzed by the four-domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2d8434ea12a873065756184d41207f7
https://pubmed.ncbi.nlm.nih.gov/34861937
https://pubmed.ncbi.nlm.nih.gov/34861937
Publikováno v:
Viral Replication Enzymes and their Inhibitors Part B ISBN: 9780323900164
Hepatitis B virus (HBV) is a hepatotropic, partially double-stranded DNA virus that replicates by reverse transcription and is a major cause of chronic liver disease and hepatocellular carcinoma. Reverse transcription is catalyzed by the four-domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0322aa50da14766beee37a423184c6bc
https://doi.org/10.1016/bs.enz.2021.06.010
https://doi.org/10.1016/bs.enz.2021.06.010
Autor:
Connor D Kendrick, Daniel N. Clark, Desiree N Owsley, Nicole A Skalka, Daniel L Braun, Anastasia F Bowersox, Timothy S Buhlig, Kortney D James, Alfredo J Aranda
Publikováno v:
Viruses
Viruses, Vol 12, Iss 570, p 570 (2020)
Viruses, Vol 12, Iss 570, p 570 (2020)
Approximately 250 million people are living with chronic hepatitis B virus (HBV) infections, which claim nearly a million lives annually. The target of all current HBV drug therapies (except interferon) is the viral polymerase; specifically, the reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ce3b17eec85df15c2319b012a1a163
http://europepmc.org/articles/PMC7291194
http://europepmc.org/articles/PMC7291194
Publikováno v:
Journal of Virology. 90:486-496
Hepatitis B virus (HBV) infects hundreds of millions of people worldwide and causes acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HBV is an enveloped virus with a relaxed circular (RC) DNA genome. In the nuclei of infected hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac12a9f8af07cb3fec2a22bb07deec0
https://doi.org/10.1128/jvi.01263-15
https://doi.org/10.1128/jvi.01263-15
Autor:
Jianming Hu, Daniel N. Clark
Publikováno v:
Future Virology. 10:283-295
Infection with HBV is common worldwide, with over 350 million chronic carriers. Chronic HBV infection is associated with cirrhosis and hepatocellular carcinoma. All currently available oral antivirals are directed against the HBV polymerase enzyme, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6937de67dabdbc03faca754819e599
https://doi.org/10.2217/fvl.14.113
https://doi.org/10.2217/fvl.14.113
Publikováno v:
Methods in Molecular Biology ISBN: 9781493966981
Methods Mol Biol
Methods Mol Biol
The hepatitis B virus (HBV) polymerase synthesizes the viral DNA genome from the pre-genomic RNA (pgRNA) template through reverse transcription. Initiation of viral DNA synthesis is accomplished via a novel protein priming mechanism, so named because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e5885e203a4282bebd788039c18f84
https://doi.org/10.1007/978-1-4939-6700-1_13
https://doi.org/10.1007/978-1-4939-6700-1_13
Autor:
Daniel N. Clark, Jianming Hu
Hepatitis B virus (HBV) infections rely on the proper functioning of the viral polymerase enzyme, a specialized reverse transcriptase (RT) with multiple activities. All currently approved antiviral drugs for the treatment of chronic hepatitis B virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70484d7746bf2d8dd83ea8f04d0b83a
https://europepmc.org/articles/PMC4639421/
https://europepmc.org/articles/PMC4639421/