Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Daniel N Bolon"'
Autor:
David Mavor, Kyle Barlow, Samuel Thompson, Benjamin A Barad, Alain R Bonny, Clinton L Cario, Garrett Gaskins, Zairan Liu, Laura Deming, Seth D Axen, Elena Caceres, Weilin Chen, Adolfo Cuesta, Rachel E Gate, Evan M Green, Kaitlin R Hulce, Weiyue Ji, Lillian R Kenner, Bruk Mensa, Leanna S Morinishi, Steven M Moss, Marco Mravic, Ryan K Muir, Stefan Niekamp, Chimno I Nnadi, Eugene Palovcak, Erin M Poss, Tyler D Ross, Eugenia C Salcedo, Stephanie K See, Meena Subramaniam, Allison W Wong, Jennifer Li, Kurt S Thorn, Shane Ó Conchúir, Benjamin P Roscoe, Eric D Chow, Joseph L DeRisi, Tanja Kortemme, Daniel N Bolon, James S Fraser
Publikováno v:
eLife, Vol 5 (2016)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance
Externí odkaz:
https://doaj.org/article/f3e8373dbc7b4012a1c82425c9fb49fb
Autor:
Matthieu Foll, Yu-Ping Poh, Nicholas Renzette, Anna Ferrer-Admetlla, Claudia Bank, Hyunjin Shim, Anna-Sapfo Malaspinas, Gregory Ewing, Ping Liu, Daniel Wegmann, Daniel R Caffrey, Konstantin B Zeldovich, Daniel N Bolon, Jennifer P Wang, Timothy F Kowalik, Celia A Schiffer, Robert W Finberg, Jeffrey D Jensen
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004185 (2014)
The challenge of distinguishing genetic drift from selection remains a central focus of population genetics. Time-sampled data may provide a powerful tool for distinguishing these processes, and we here propose approximate Bayesian, maximum likelihoo
Externí odkaz:
https://doaj.org/article/c83d55bae4ba41bfac40d6f845e6e97e
Autor:
David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://doaj.org/article/120375a9425d4b15800ba82e59af4543
Autor:
Inês Fragata, Claudia Bank, Pamela A. Cote-Hammarlof, Konstantin B. Zeldovich, Julia M. Flynn, David Mavor, Daniel N. Bolon
Publikováno v:
Molecular Biology and Evolution
bioRxiv
Cote-Hammarlof, Pamela A; Fragata, Inês; Flynn, Julia; Mavor, David; Zeldovich, Konstantin B; Bank, Claudia; Bolon, Daniel N A (2021). The Adaptive Potential of the Middle Domain of Yeast Hsp90. Molecular Biology and Evolution, 38(2), pp. 368-379. Oxford University Press 10.1093/molbev/msaa211
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
bioRxiv
Cote-Hammarlof, Pamela A; Fragata, Inês; Flynn, Julia; Mavor, David; Zeldovich, Konstantin B; Bank, Claudia; Bolon, Daniel N A (2021). The Adaptive Potential of the Middle Domain of Yeast Hsp90. Molecular Biology and Evolution, 38(2), pp. 368-379. Oxford University Press 10.1093/molbev/msaa211
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The distribution of fitness effects (DFEs) of new mutations across different environments quantifies the potential for adaptation in a given environment and its cost in others. So far, results regarding the cost of adaptation across environments have
Autor:
Claudia Bank, Daniel N. Bolon, Julia M. Flynn, David Mavor, Carl Hollins, Inês Fragata, Pamela A. Cote-Hammarlof, Ammeret Rossouw
Publikováno v:
eLife, Vol 9 (2020)
eLife
Flynn, Julia M; Rossouw, Ammeret; Cote-Hammarlof, Pamela; Fragata, Inês; Mavor, David; Hollins, Carl; Bank, Claudia; Bolon, Daniel NA (2020). Comprehensive fitness maps of Hsp90 show widespread environmental dependence. eLife, 9 eLife Sciences Publications 10.7554/eLife.53810
eLife
Flynn, Julia M; Rossouw, Ammeret; Cote-Hammarlof, Pamela; Fragata, Inês; Mavor, David; Hollins, Carl; Bank, Claudia; Bolon, Daniel NA (2020). Comprehensive fitness maps of Hsp90 show widespread environmental dependence. eLife, 9 eLife Sciences Publications 10.7554/eLife.53810
Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains unknown. Using deep mutational scanning, we engineered yeast with all 44,604 single codon changes
Autor:
Claudia Bank, Nicholas Renzette, Sebastian Matuszewski, Robert W. Finberg, Timothy F. Kowalik, Daniel N. Bolon, Louise Ormond, Jennifer P. Wang, Jeffrey D. Jensen, Ping Liu, Konstantin B. Zeldovich
Publikováno v:
Genome Biology and Evolution
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
This deposit is composed by the main article plus the supplementary materials of the publication. Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with
Publikováno v:
Nature Structural & Molecular Biology. 24:1-4
The Eighth International Conference on the Hsp90 Chaperone Machine took place in November 2016 at the Seeon Abbey in Germany. This year's program focused on a variety of topics, reflecting Hsp90's diverse roles in cellular and physiological function.
Autor:
Kelly M. Thayer, Jennifer P. Wang, Konstantin B. Zeldovich, Jeffrey D. Jensen, N. KurtYilmaz, Kristina L. Prachanronarong, L. Safak Yilmaz, Robert W. Finberg, Ayşegül Özen, Celia A. Schiffer, Daniel N. Bolon, Timothy F. Kowalik
Publikováno v:
Journal of Chemical Theory and Computation. 12:6098-6108
Neuraminidase (NA) inhibitors are used for the prevention and treatment of influenza A virus infections. Two subtypes of NA, N1 and N2, predominate in viruses that infect humans, but differential patterns of drug resistance have emerged in each subty
Autor:
Celia A. Schiffer, Daniel N. Bolon, Ellen A. Nalivaika, Troy W. Whitfield, Gily S. Nachum, Mina Henes, Nese Kurt Yilmaz, Klajdi Kosovrasti, Florian Leidner, Gordon J. Lockbaum
Publikováno v:
Biochemistry
Protease inhibitors have the highest potency among antiviral therapies against HIV-1 infections, yet the virus can evolve resistance. Darunavir (DRV), currently the most potent Food and Drug Administration-approved protease inhibitor, retains potency