Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Daniel N A Bolon"'
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003600 (2013)
In natural systems, selection acts on both protein sequence and expression level, but it is unclear how selection integrates over these two dimensions. We recently developed the EMPIRIC approach to systematically determine the fitness effects of all
Externí odkaz:
https://doaj.org/article/c0b6ef4ded4f436894a5a0aecde6d9b0
Autor:
Ala M. Shaqra, Sarah N. Zvornicanin, Qiu Yu J. Huang, Gordon J. Lockbaum, Mark Knapp, Laura Tandeske, David T. Bakan, Julia Flynn, Daniel N. A. Bolon, Stephanie Moquin, Dustin Dovala, Nese Kurt Yilmaz, Celia A. Schiffer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The authors determined crystal structures of the main protease (Mpro) of SARS-CoV-2 bound to substrate peptides. These structures define the substrate envelope and enable identification of sites that may be susceptible to drug resistance.
Externí odkaz:
https://doaj.org/article/9bf0515b0c364d1eb5c19629a361ea7c
Publikováno v:
Protein Sci
The infectivity of HIV-1 requires its protease cleave multiple cut-sites with low sequence similarity. The diversity of cleavage sites has made it challenging to investigate the underlying sequence properties that determine binding and turnover of su
Publikováno v:
Virus evolution. 7(2)
Investigating the relationships between protein function and fitness provides keys for understanding biochemical mechanisms that underly evolution. Mutations with partial fitness defects can delineate the threshold of biochemical function required fo
Publikováno v:
Protein Science. 28:671-671
The last decade has seen a growing number of experiments aimed at systematically mapping the effects of mutations in different proteins, and of attempting to correlate their biophysical and biochemical effects with organismal fitness. While insightfu
Publikováno v:
Protein science : a publication of the Protein Society. 25(7)