Výsledky vyhledávání - "Daniel Muñoz-Espín"

Akademický článek

Cellular senescence in cancer: from mechanisms to detection

Autor: Hui‐Ling Ou, Reuben Hoffmann, Cristina González‐López, Gary J. Doherty, James E. Korkola, Daniel Muñoz‐Espín

Publikováno v: Molecular Oncology, Vol 15, Iss 10, Pp 2634-2671 (2021)

Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in response to stress. This response also involves other distinct morphological and intracellular changes including alterations in gene expression and epigenetic m

Externí odkaz: https://doaj.org/article/f762a6bb0f37468c999497ca19af1f9b

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Akademický článek

Targeting senescent cells in translational medicine

Autor: Marta Paez‐Ribes, Estela González‐Gualda, Gary J Doherty, Daniel Muñoz‐Espín

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-19 (2019)

Abstract Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is consid

Externí odkaz: https://doaj.org/article/f1552ee743934e8493ca70abe9e11fb1

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Akademický článek

Nanocarriers targeting senescent cells

Autor: Daniel Muñoz-Espín

Publikováno v: Translational Medicine of Aging, Vol 3, Iss , Pp 1-5 (2019)

Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of s

Externí odkaz: https://doaj.org/article/60963e2fd06743e0b6f8c22ca2339444

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Akademický článek

A versatile drug delivery system targeting senescent cells

Autor: Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-18 (2018)

Abstract Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent

Externí odkaz: https://doaj.org/article/d67df62499c14123a2c81e830cc433e4

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Akademický článek

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

Autor: Jose M. Bermúdez-Muñoz, Adelaida M. Celaya, Ángela García-Mato, Daniel Muñoz-Espín, Lourdes Rodríguez-de la Rosa, Manuel Serrano, Isabel Varela-Nieto

Publikováno v: Antioxidants, Vol 10, Iss 9, p 1351 (2021)

Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to sustained SAPK activa

Externí odkaz: https://doaj.org/article/748624f927dc4e19a79baea627396416

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Targeting Senescence as a Therapeutic Opportunity for Triple-Negative Breast Cancer

Autor: Bruno de Paula, Rosalind Kieran, Samantha Shui Yuan Koh, Susanne Crocamo, Eliana Abdelhay, Daniel Muñoz-Espín

Publikováno v: Molecular Cancer Therapeutics. 22:583-598

Triple-negative breast cancer (TNBC) is associated with an elevated risk of recurrence and poor prognosis. Historically, only chemotherapy was available as systemic treatment, but immunotherapy and targeted therapies currently offer prolonged benefit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa341fabd29517d62d208476cf39999a
https://doi.org/10.1158/1535-7163.mct-22-0643

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