Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia

Autor: Miren Lasaga, Paula Río, Amaia Vilas-Zornoza, Nuria Planell, Susana Navarro, Diego Alignani, Beatriz Fernández-Varas, Daniel Mouzo, Josune Zubicaray, Roser M. Pujol, Eileen Nicoletti, Jonathan D. Schwartz, Julián Sevilla, Marina Ainciburi, Asier Ullate-Agote, Jordi Surrallés, Rosario Perona, Leandro Sastre, Felipe Prosper, David Gomez-Cabrero, Juan A. Bueren

Publikováno v: Haematologica, Vol 108, Iss 10 (2023)

Clinical trials have shown that lentiviral-mediated gene therapy can ameliorate bone marrow failure (BMF) in nonconditioned Fanconi anemia (FA) patients resulting from the proliferative advantage of corrected FA hematopoietic stem and progenitor cell

Externí odkaz: https://doaj.org/article/d53a95898f024aef96171022924acc08

Comparative Proteomics of Potato Cultivars with a Variable Dormancy Period

Autor: Daniel Mouzo, Raquel Rodríguez-Vázquez, Carlos Barrio, Lucio García, Carlos Zapata

Publikováno v: Molecules, Vol 27, Iss 19, p 6621 (2022)

The control of the duration of the dormancy phase is a significant challenge in the potato industry and for seed producers. However, the proteome landscape involved in the regulation of the length of the dormancy period over potato cultivars remains

Externí odkaz: https://doaj.org/article/de41e64f9c634fc0a379521d9267b78b

Phosphoproteome Analysis Using Two-Dimensional Electrophoresis Coupled with Chemical Dephosphorylation

Autor: Daniel Mouzo, Carlos Zapata, Raquel Rodríguez Vázquez

Publikováno v: Foods; Volume 11; Issue 19; Pages: 3119

Protein phosphorylation is a reversible post-translational modification (PTM) with major regulatory roles in many cellular processes. However, the analysis of phosphoproteins remains the most challenging barrier in the prevailing proteome research. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8432c50a2da9be6faa0210f3bce3d8
https://pubmed.ncbi.nlm.nih.gov/36230195

The Major Storage Protein in Potato Tuber Is Mobilized by a Mechanism Dependent on Its Phosphorylation Status

Autor: Daniel Franco, Carlos Zapata, L. García, María López-Pedrouso, Daniel Mouzo, Javier Bernal

Publikováno v: International Journal of Molecular Sciences
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1889 (2019)
Volume 20
Issue 8

The role of the protein phosphorylation mechanism in the mobilization of vegetative storage proteins (VSPs) is totally unknown. Patatin is the major VSP of the potato (Solanum tuberosum L.) tuber that encompasses multiple differentially phosphorylate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15589e4b16f37712ac2c77b9781fad57
https://pubmed.ncbi.nlm.nih.gov/30999555

Advances in the Biology of Seed and Vegetative Storage Proteins Based on Two-Dimensional Electrophoresis Coupled to Mass Spectrometry

Autor: Javier Bernal, Carlos Zapata, Daniel Franco, Daniel Mouzo, María López-Pedrouso

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 10, p 2462 (2018)

Seed storage proteins play a fundamental role in plant reproduction and human nutrition. They accumulate during seed development as reserve material for germination and seedling growth and are a major source of dietary protein for human consumption.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6534e80e76289d29100df06fb7905549
https://doi.org/10.3390/molecules23102462