Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daniel Mobilio"'
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101628- (2022)
Summary: Human neural stem cells (hNSCs) are a valuable tool in brain cancer research since they are used as a normal control for multiple assays, mainly pertaining to toxicity. Here, we present a protocol to safely and successfully derive and cultur
Externí odkaz:
https://doaj.org/article/2777d6ce58714b06b642178c4b97da57
Autor:
Blessing Iquo Bassey-Archibong, Chirayu Rajendra Chokshi, Nikoo Aghaei, Agata Monika Kieliszek, Nazanin Tatari, Dillon McKenna, Mohini Singh, Minomi Kalpana Subapanditha, Arun Parmar, Daniel Mobilio, Neil Savage, Fred Lam, Tomas Tokar, John Provias, Yu Lu, Shawn Christopher Chafe, Charles Swanton, Robert Edward Hynds, Chitra Venugopal, Sheila Kumari Singh
Brain metastases (BM) are the most common brain neoplasm in adults. Current BM therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for a better understanding of the disease. Herein, we analyzed the transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f688de303b5131216db099f4c299e47
Autor:
Agata M. Kieliszek, Daniel Mobilio, Blessing I. Bassey-Archibong, Jarrod Johnson, Nikoo Aghaei, William Gwynne, Dillon McKenna, Minomi K. Subapanditha, Chitra Venugopal, Jakob Magolan, Sheila K. Singh
Publikováno v:
Cancer Research. 83:2474-2474
INTRO: Patients with brain metastases (BM) face a 90% mortality rate within one year of their diagnosis and they lack targeted therapeutic options, particularly preventative or interceptional ones. METHODS: The Singh lab has generated a large in-hous
Autor:
Sheila Singh, Chirayu Chokshi, David Tieu, Kevin Brown, Chitra Venugopal, Martin Rossotti, Katherine Chan, Amy Tong, Laura Kuhlmann, Lina Liu, Benjamin Brakel, Vaseem Shaikh, William Maich, Yujin Suk, Daniel Mobilio, Neil Savage, Nikoo Aghaei, Minomi Subapanditha, Dillon McKenna, Vladimir Ignatchenko, Joseph Salamoun, Peter Wipf, Elizabeth Sharlow, John Provias, Jian-Qiang Lu, Naresh Murty, John Lazo, Thomas Kislinger, Kevin Henry, Yu Lu, Jason Moffat
Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma (GBM), an aggressive brain tumor. Here, we explore the functional drivers of post-treatment recurrent GBM. By conducting genome-wide CRISPR-Cas9 screens in patient-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::934ca2c72f06c0fdd3cbf32e27e60300
https://doi.org/10.21203/rs.3.rs-1871890/v1
https://doi.org/10.21203/rs.3.rs-1871890/v1
Autor:
Agata Kieliszek, Daniel Mobilio, Blessing Bassey-Archibong, Jarrod Johnson, Chitra Venugopal, Jakob Magolan, Sheila Singh
Publikováno v:
Neuro-Oncology. 24:vii98-vii99
The current standard of care for (surgery and radiation) for brain metastases (BM) is inadequate as BM have a 90% mortality rate within one year of diagnosis, posing a large unmet clinical need. The Singh lab has generated a large in-house biobank of
Autor:
William D. Gwynne, Yujin Suk, Stefan Custers, Nicholas Mikolajewicz, Jeremy K. Chan, Zsolt Zador, Shawn C. Chafe, Kui Zhai, Laura Escudero, Cunjie Zhang, Olga Zaslaver, Chirayu Chokshi, Muhammad Vaseem Shaikh, David Bakhshinyan, Ian Burns, Iqra Chaudhry, Omri Nachmani, Daniel Mobilio, William T. Maich, Patricia Mero, Kevin R. Brown, Andrew T. Quaile, Chitra Venugopal, Jason Moffat, J. Rafael Montenegro-Burke, Sheila K. Singh
Publikováno v:
Cancer cell. 40(12)
MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic screening and metabolomic profiling to identify multiple cancer-selectiv
Autor:
Agata Kieliszek, Daniel Mobilio, Blessing Bassey-Archibong, Jarrod Johnson, Dillon McKenna, Chitra Venugopal, Jakob Magolan, Sheila Singh
Publikováno v:
Neuro-Oncology Advances. 4:i3-i3
The current standard of care (surgery and radiation) for brain metastases (BM) is inadequate as BM have a 90% mortality rate within one year of diagnosis, posing a large unmet clinical need. The Singh lab has generated a large in-house biobank of pat
Autor:
Benjamin Brakel, Chirayu Chokshi, Martin Rossotti, Chitra Venugopal, Sabra Salim, Daniel Mobilio, Shawn Chafe, Kevin Henry, Sheila Singh
Publikováno v:
Neuro-Oncology Advances. 4:i24-i24
No standardized treatments exist for patients with treatment-refractory brain metastasis, glioblastoma and other recurrent brain tumours. Given the aggressive nature of these diseases and difficulty in modelling tumour recurrence, minimal efforts hav
Publikováno v:
Neuro-Oncology Advances. 4:i5-i5
BACKGROUND Brain metastases are secondary tumors that predominantly arise from the spread of lung, skin, and breast cancers. The current standard of care for brain metastases is complete surgical resection, with a median survival of four months. Ther
Publikováno v:
Cancer Weekly; 12/19/2023, p576-576, 1p