Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniel Merritt Bowles"'
Autor:
Angela Wolford, Heather Eng, Yanwei Zhang, Suvi T. M. Orr, Kay Ahn, Daniel W. Widlicka, Carlin Okerberg, Amit S. Kalgutkar, Yingmei Qi, Samantha N. Spath, Paul D. Bonin, Dilinie P. Fernando, Aaron C. Smith, Tim F. Ryder, Karen Walters, Yan Zhang, David Hepworth, Wenhua Jiao, Joseph S. Warmus, Benjamin N. Rocke, Tristan S. Maurer, Daniel Merritt Bowles, Daniel W. Kung, Scott W. Bagley, Philip A. Carpino, Roger B. Ruggeri, Gang Xing, Leonard Buckbinder, Edward L. Conn, Matthew S. Dowling, Raman Sharma
Publikováno v:
Journal of Medicinal Chemistry. 58:8513-8528
Myeloperoxidase (MPO) is a heme peroxidase that catalyzes the production of hypochlorous acid. Clinical evidence suggests a causal role for MPO in various autoimmune and inflammatory disorders including vasculitis and cardiovascular and Parkinson's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac30d6c8fa4af6183864fd024f9b6af
https://doi.org/10.1021/acs.jmedchem.5b00963
https://doi.org/10.1021/acs.jmedchem.5b00963
Publikováno v:
Synthetic Communications. 42:1855-1863
Air oxidation of N-cyclopropylanilines was shown to occur under either ambient conditions or accelerated conditions (warming or shining light) in an open container. A subsequent fragmentation resulted in formation of the corresponding acetamide. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9967a7c793da091ae4ded423128f1fa0
https://doi.org/10.1080/00397911.2010.545166
https://doi.org/10.1080/00397911.2010.545166
Autor:
Xiangyang Chen, E. Jason Kiser, David W. Piotrowski, Robert A. Wade, Cuiman Cai, Matthew F. Sammons, Catherine Angela Hulford, Daniel Merritt Bowles, Sandra M. Jennings, Agustin Casimiro-Garcia, Charles Boos
Publikováno v:
Tetrahedron Letters. 52:7025-7029
The large scale synthesis of functionalized 2-pyridylboronate 8 and optimization of its Suzuki–Miyaura coupling to chloropyrazoline (R)-7 to provide a scalable synthesis of mineralocorticoid antagonist (R)-1 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b13eef5617fddbd04d994c65772dd3b
https://doi.org/10.1016/j.tetlet.2011.10.052
https://doi.org/10.1016/j.tetlet.2011.10.052
Autor:
Kevin K.-C. Liu, Qinhua Huang, Paul F. Richardson, Jinjiang Zhu, Graham L. Smith, Daniel Merritt Bowles, Neal W. Sach
Publikováno v:
Organic Process Research & Development. 15:556-564
On the basis of a more practical and scalable route to an iodothiophene, an efficient and reliable synthesis has been developed for three selective PI3K inhibitors. From this advanced intermediate, the three title compounds were each prepared in five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b67e21f9996903328ff111a65066251
https://doi.org/10.1021/op100286g
https://doi.org/10.1021/op100286g
Autor:
David C. Boyles, Stephanie Schuyler, Edward J. Hessler, Jeffrey A. Pfefferkorn, Daniel Merritt Bowles, Chulho Choi
Publikováno v:
Organic Process Research & Development. 15:148-157
Early process development work toward a promising pyrazole-based HMG-CoA reductase inhibitor is described. PF-03052334-02 (1) was prepared in 14 synthetic steps with a 21% overall yield, highlighted by a modified three-step hydroxypyrazole formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3244cefc6fb774fd450882bea2ca9fe2
https://doi.org/10.1021/op100268e
https://doi.org/10.1021/op100268e
Autor:
Daniel Merritt Bowles, David C. Schineman, Markus Tamm, Kurtis G. Ritsema, Jonathan Mark Miller, William Keun Chan Park, David C. Boyles, Scott D. Larsen, Richard H. Hutchings, Timothy T. Curran, Gary Louis Bolton
Publikováno v:
Organic Process Research & Development. 12:1183-1187
Development work toward an enabling synthesis of preparative scale batches of an imidazole-based HMG-CoA reductase inhibitor is described. The desired target was synthesized in 16% yield over 7 steps, highlighted by an imidazole-forming condensation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176604024aac368f6520a3afb36d0c26
https://doi.org/10.1021/op800092e
https://doi.org/10.1021/op800092e
Publikováno v:
ChemInform. 43
Compounds (I) decompose to (II) and (III) even when exposed to light of the laboratory and air.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1bb742f7587d12d3b526b5bd9ca2032
https://doi.org/10.1002/chin.201238052
https://doi.org/10.1002/chin.201238052
Autor:
Erasga Noe Ouano, David C. Boyles, Chitase Lee, Vaishali Sahasrabudhe, Emi Kimoto, Mark C. Kowala, Yurong Lai, Jonathan Chupka, Bharat K. Trivedi, Xue-Min Cheng, Jeffrey C. Hanselman, Valerie Askew, Zhiwu Lin, P. L. Barclay, Bruce Auerbach, David B. Duignan, Jeffrey A. Pfefferkorn, Theunis C. Goosen, Bo Feng, Lisa Dillon, Richard H. Hutchings, Andrew Robertson, Robert M. Kennedy, Bradley D. Tait, Ayman El-Kattan, Scott D. Larsen, Gina Lu, Daniel Merritt Bowles, Vu Le, Mark Milad, Erick Kindt, Karl Olsen, Mark Richard Bush, John Litchfield, Carine Boustany, Rebecca Bakker-Arkema, Renato J. Scialis, Yi An Bi, Catherine Sekerke, Jaap Mandema, Karen Atkinson
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
The design of drugs with selective tissue distribution can be an effective strategy for enhancing efficacy and safety, but understanding the translation of preclinical tissue distribution data to the clinic remains an important challenge. As part of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944f1fb672305f2baa7a70a0ffb7d328
https://pubmed.ncbi.nlm.nih.gov/21183342
https://pubmed.ncbi.nlm.nih.gov/21183342
Autor:
Steven R. Miller, Scott D. Larsen, Yuntao Song, David C. Boyles, Jeffrey A. Pfefferkorn, Chulho Choi, William Kissel, Bharat K. Trivedi, Daniel Merritt Bowles, Kuai Lin Sun
Publikováno v:
ChemInform. 38
This paper describes the development of an efficient and scalable second generation synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors. Compound 1 was identified as part of a discovery program aimed at finding improved treatments for hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c135c7e5597e87adaacda948a6c81bb
https://doi.org/10.1002/chin.200748103
https://doi.org/10.1002/chin.200748103