Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Daniel Medina-Cleghorn"'
Autor:
Kurt S. Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S. Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K. Leung, Raymond A. Ng, Andrew J. Ambrose, Yinyan Tang, Michelle R. Arkin, Adam R. Renslo
Publikováno v:
Journal of the American Chemical Society, vol 145, iss 18
Caspases are a family of cysteine-dependent proteases with important cellular functions in inflammation and apoptosis, while also implicated in human diseases. Classical chemical tools to study caspase functions lack selectivity for specific caspase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2313ac4d40ba23573c730af3ed6f119
https://doi.org/10.1021/jacs.2c12240
https://doi.org/10.1021/jacs.2c12240
Autor:
Kurt Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin Leung, Raymond Ng, Andrew Ambrose, Yinyan Tang, Michelle Arkin, Adam Renslo
The caspases are a family of cysteine dependent proteases with important cellular functions in inflammation and apoptosis, while also implicated in human disease. Classical chemical tools to study caspase function lack selectivity for specific caspas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8fdd89adc22c828bf880205eb77877
https://doi.org/10.26434/chemrxiv-2022-5wfm6
https://doi.org/10.26434/chemrxiv-2022-5wfm6
Autor:
Michelle R. Arkin, Markus-Frederik Bohn, Daniel Medina-Cleghorn, Kwadwo A. Opoku-Nsiah, Yi-Fan Chen, Jason E. Gestwicki, Koli Basu, Matthew Ravalin, Victoria A. Assimon, Charles S. Craik, Panagiotis Theofilas, Lea T. Grinberg
Publikováno v:
Nat Chem Biol
Nature chemical biology, vol 15, iss 8
Nature chemical biology, vol 15, iss 8
Protein-protein interactions between E3 ubiquitin ligases and protein termini shape the proteome. These interactions are sensitive to proteolysis, which alters the ensemble of cellular N- and C-termini. We have identified a mechanism wherein caspase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e648b3ce5cf10e3377c53b6fdb6ebb96
https://europepmc.org/articles/PMC6693490/
https://europepmc.org/articles/PMC6693490/
Autor:
Paige M. Bracci, Leon Bernal-Mizrachi, Jacques Riby, Daniel Medina-Cleghorn, Alan Hubbard, Lucia Conde, Daniel K. Nomura, Jianqing Zhang, Christine F. Skibola
Publikováno v:
Oncoscience
Diffuse large B-cell lymphoma is an aggressive, genetically heterogenerous disease and the most common type of non-Hodgkin lymphoma among adults. To gain further insights into the etiology of DLBCL and to discover potential disease-related factors, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5281b651e3e301c50cfe9c72a98023d4
https://doi.org/10.18632/oncoscience.289
https://doi.org/10.18632/oncoscience.289
Autor:
Daniel Medina-Cleghorn, Michael E. Lee, Rebecca A. Kohnz, Luke N. Latimer, John E. Dueber, Daniel K. Nomura
Publikováno v:
Metabolic Engineering. 25:20-29
Fermentation of xylose, a major constituent of lignocellulose, will be important for expanding sustainable biofuel production. We sought to better understand the effects of intrinsic (genotypic) and extrinsic (growth conditions) variables on optimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d24a3826315e72851a4824053dc0d15
https://doi.org/10.1016/j.ymben.2014.06.002
https://doi.org/10.1016/j.ymben.2014.06.002
Autor:
Joseph Orr, Sarah M. King, Daniel K. Nomura, Melinda M. Mulvihill, Ann Heslin, Daniel Medina-Cleghorn, Patrick J. Morris, Ronald M. Krauss
Publikováno v:
ACS Chemical Biology
ACS chemical biology, vol 9, iss 5
ACS chemical biology, vol 9, iss 5
Humans are prevalently exposed to organophosphorus flame retardants (OPFRs) contained in consumer products and electronics, though their toxicological effects and mechanisms remain poorly understood. We show here that OPFRs inhibit specific liver car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a70b321e1786c8158a6bea231afd4c8
http://europepmc.org/articles/PMC4027947
http://europepmc.org/articles/PMC4027947
Autor:
Patrick J. Morris, Daniel K. Nomura, Daniel Medina-Cleghorn, Melinda M. Mulvihill, Ann Heslin
Publikováno v:
ACS Chemical Biology. 9:423-432
We are environmentally exposed to countless synthetic chemicals on a daily basis with an increasing number of these chemical exposures linked to adverse health effects. However, our understanding of the (patho)physiological effects of these chemicals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6f91f2ddd81caf7dbcd6fa31a09b61
https://doi.org/10.1021/cb400796c
https://doi.org/10.1021/cb400796c
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 465:427-440
One of the more provocative realizations that have come out of the genome sequencing projects is that organisms possess a large number of uncharacterized or poorly characterized enzymes. This finding belies the commonly held notion that our knowledge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb494f1befe26b2d463bf9dcce1b40b
https://doi.org/10.1007/s00424-012-1201-0
https://doi.org/10.1007/s00424-012-1201-0
Autor:
Wilson Jacob Filho, Maria B. Mejia, Claudia K. Suemoto, Renata Elaine Paraizo Leite, Marcus Y. Chin, Udo Rueb, Ricardo Nitrini, Sara Dunlop, Roberta Diehl Rodriguez, William W. Seeley, Carlos Augusto Pasqualucci, Michelle R. Arkin, Ana Tereza Di Lorenzo Alho, Lea T. Grinberg, Ana Maria Cuervo, Daniel Medina-Cleghorn, Helmut Heinsen, Austin Nguy, Julia M. Thackrey, Panos Theofilas, Bruce L. Miller, John Neuhaus, Alexander J. Ehrenberg, Camila F. Nascimento
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Clarifying the mechanisms connecting neurofibrillary tangle (NFT) neurotoxicity to neuronal dysfunction in humans is likely to be pivotal for developing effective treatments for Alzheimer's disease (AD). To model the temporal progression of AD in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274522abbbaf61507f77e4f7549e8a7e
https://pubmed.ncbi.nlm.nih.gov/29031088
https://pubmed.ncbi.nlm.nih.gov/29031088
Autor:
Breanna Ford, Ann Heslin, Daniel Medina-Cleghorn, Esha D. Dalvie, Karl Fisher, Daniel K. Nomura, Leslie A. Bateman
Publikováno v:
Chemistry & biology, vol 22, iss 10
SummaryWe are exposed to a growing number of chemicals in our environment, most of which have not been characterized in terms of their toxicological potential or mechanisms. Here, we employ a chemoproteomic platform to map the cysteine reactivity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3426db0c197a4a9a2775f1b7c096b087
https://europepmc.org/articles/PMC4621755/
https://europepmc.org/articles/PMC4621755/