Výsledky vyhledávání - "Daniel McNaught Flores"

Akademický článek

Non-Imidazole Histamine H3 Ligands. Part VII. Synthesis, In Vitro and In Vivo Characterization of 5-Substituted-2-thiazol-4-n-propylpiperazines

Autor: Roman Guryn, Marek Staszewski, Anna Stasiak, Daniel McNaught Flores, Wiesława Agnieszka Fogel, Rob Leurs, Krzysztof Walczyński

Publikováno v: Molecules, Vol 23, Iss 2, p 326 (2018)

H3 receptors present on histaminergic and non-histaminergic neurons, act as autoreceptors or heteroreceptors controlling neurotransmitter release and synthesis. Previous, studies have found that the compound N-methyl-N-3-phenylalkyl-2-[2-(4-n-propylp

Externí odkaz: https://doaj.org/article/480147e5a58a45b09f09361c187ad6e2

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4-Hydroxypiperidines and their flexible 3-(amino)propyloxy analogues as non-imidazole histamine H3 receptor antagonist

Autor: Daniel McNaught Flores, Wiesława Agnieszka Fogel, Rob Leurs, Krzysztof Walczyński, Beata Olszewska, Anna Stasiak

Publikováno v: International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1243
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 19:1243, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
Olszewska, B, Stasiak, A, McNaught Flores, D, Fogel, W A, Leurs, R & Walczyński, K 2018, ' 4-Hydroxypiperidines and their flexible 3-(amino)propyloxy analogues as non-imidazole histamine H 3 receptor antagonist : Further structure-activity relationship exploration and in vitro and in vivo pharmacological evaluation ', International Journal of Molecular Sciences, vol. 19, 1243, pp. 1-19 . https://doi.org/10.3390/ijms19041243
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1243 (2018)

Presynaptic histamine H3 receptors (H3R) act as auto- or heteroreceptors controlling, respectively, the release of histamine and of other neurotransmitters in the central nervous system (CNS). The extracellular levels of several neurotransmitters are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da4738dcf8b829ab8db59a36e7d4f8e
http://www.scopus.com/inward/record.url?scp=85045908359&partnerID=8YFLogxK

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Design, synthesis, and in vitro and in vivo characterization of 1-4-[4-(substituted)piperazin-1-yl]butyl guanidines and their piperidine analogues as histamine H-3 receptor antagonists

Autor: Anna Stasiak, Rob Leurs, Katarzyna Kieć-Kononowicz, Marek Staszewski, Tadeusz Karcz, Krzysztof Walczyński, Wiesława Agnieszka Fogel, Daniel McNaught Flores

Publikováno v: Staszewski, M, Stasiak, A, Karcz, T, McNaught Flores, D, Fogel, W A, Kieć-Kononowicz, K, Leurs, R & Walczyński, K 2019, ' Design, synthesis, and: In vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H 3 receptor antagonists ', MedChemComm, vol. 10, no. 2, pp. 234-251 . https://doi.org/10.1039/c8md00527c
MedChemComm, 10(2), 234-251. Royal Society of Chemistry

Previously, we have shown that 1-substituted-[4-(7-phenoxyheptylpiperazin-1-yl)butyl]guanidine with electron withdrawing substituents at position 4 in the benzyl moiety exhibits high in vitro affinities toward the guinea pig jejunal histamine H 3 rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccb898e5514cfd2991fd221195e001f
https://ruj.uj.edu.pl/xmlui/handle/item/121852

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Design, synthesis, and

Autor: Marek, Staszewski, Anna, Stasiak, Tadeusz, Karcz, Daniel, McNaught Flores, Wiesława Agnieszka, Fogel, Katarzyna, Kieć-Kononowicz, Rob, Leurs, Krzysztof, Walczyński

Publikováno v: MedChemComm. 10(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bac6ef792e7973b3f13dba405c54bf6c
https://pubmed.ncbi.nlm.nih.gov/30881612

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Non-imidazole histamine H3 Ligands. Part VII. Synthesis, in vitro and in vivo characterization of 5-substituted-2-thiazol-4-n-propylpiperazines

Autor: Daniel McNaught Flores, Krzysztof Walczyński, Anna Stasiak, Wiesława Agnieszka Fogel, Rob Leurs, Roman Guryn, Marek Staszewski

Publikováno v: Guryn, R, Staszewski, M, Stasiak, A, McNaught Flores, D, Fogel, W A, Leurs, R & Walczynski, K 2018, ' Non-imidazole histamine H 3 Ligands. Part VII. Synthesis, in vitro and in vivo characterization of 5-substituted-2-thiazol-4-n-propylpiperazines ', Molecules, vol. 23, no. 2, 326, pp. 1-20 . https://doi.org/10.3390/molecules23020326
Molecules; Volume 23; Issue 2; Pages: 326
Molecules, 23(2):326, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 2, p 326 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b333cc80cc747877a61b57206b1ca4
https://research.vu.nl/en/publications/a37d0544-9bac-483c-a3d8-821343e90423

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Histamine Modulates Isoproterenol Efficacy at the β2 Adrenoceptor: Inferences Regarding Allosteric Modulation by Imidazole-Containing Compounds

Autor: Jos G Trujillo-Ferrara, Jos A Arias-Montao, Daniel McNaught-Flores, Marvin A Soriano-Ursa, Jos Correa-Basurto

Publikováno v: Biochemistry & Physiology: Open Access.

In the last few years, evidence has been mounting of the possible allosteric modulation of second messenger formation on β2-adrenoceptors (β2ARs) induced by non-arylethylamine compounds. We herein addressed this issue by carrying out functional and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d06daded507813997642157299e114f
https://doi.org/10.4172/2168-9652.1000114

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