Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Daniel Manrique-Castano"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Glial scar formation represents a fundamental response to central nervous system (CNS) injuries. It is mainly characterized by a well-defined spatial rearrangement of reactive astrocytes and microglia. The mechanisms underlying glial scar fo
Externí odkaz:
https://doaj.org/article/f319969c9de340bbb3227c7f1892eff9
Autor:
Daniel Manrique-Castano, Ayman ElAli
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102989- (2024)
Summary: CNS injuries are associated with profound changes in cell organization. This protocol presents a stepwise approach to quantitatively describe the spatiotemporal changes in glial cell rearrangement in the injured murine brain, which is applic
Externí odkaz:
https://doaj.org/article/571832ac25f4464b910b7314d846d3bc
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the world after Alzheimer’s disease (AD). VaD regroups heterogeneous neurological conditions in which the decline of cognitive functions, including executive functio
Externí odkaz:
https://doaj.org/article/89651896aa4e4ef9835c3d6cba69ae1d
Autor:
Daniel Manrique-Castano, Maryam Sardari, Tayana Silva de Carvalho, Thorsten R. Doeppner, Aurel Popa-Wagner, Christoph Kleinschnitz, Andrew Chan, Dirk M. Hermann
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
ATP-binding cassette (ABC) transporters prevent the access of pharmacological compounds to the ischemic brain, thereby impeding the efficacy of stroke therapies. ABC transporters can be deactivated by selective inhibitors, which potently increase the
Externí odkaz:
https://doaj.org/article/2fe4b01e3b6b4421b88f8595892a4703
Autor:
Egor Dzyubenko, Daniel Manrique-Castano, Christoph Kleinschnitz, Andreas Faissner, Dirk M. Hermann
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 11 (2018)
Neuroinflammation is one of the key components contributing to the devastating outcome of ischemic stroke. Starting with stroke onset, inflammatory processes contribute both to cell damage and tissue remodeling. The early release of alarmins triggers
Externí odkaz:
https://doaj.org/article/ffeb137a6f824e8388b2e2709277aeae
Autor:
Daniel Manrique-Castano
Staining protocol for Gfap, Iba1, and NeuN on PFA-fixed mouse brain sections.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a07890abdbf7f1a3cfd5ba29dd7fa18
https://doi.org/10.17504/protocols.io.4r3l27q5pg1y/v1
https://doi.org/10.17504/protocols.io.4r3l27q5pg1y/v1
Autor:
Mina Borbor, Lars Roll, Andreas Faissner, Dirk M. Hermann, Paraskevi Vasileiadou, Egor Dzyubenko, Daniel Manrique-Castano, Christoph Kleinschnitz
Publikováno v:
Brain, Behavior, and Immunity. 91:639-648
As an endogenous activator of toll-like receptor-4 (Tlr4), the extracellular matrix glycoprotein tenascin-C (TnC) regulates chemotaxis, phagocytosis and proinflammatory cytokine production in microglia. The role of TnC for ischemic brain injury, post
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b6806be45c421f422e65caf38ee2bd
https://doi.org/10.1016/j.bbi.2020.10.016
https://doi.org/10.1016/j.bbi.2020.10.016
Autor:
Daniel Manrique-Castano, Ayman ElAli
Publikováno v:
Cerebral Ischemia ISBN: 9780645001792
Tissue scarring upon cerebral ischemia entails a cascade of multifaceted cellular and molecular mechanisms that govern the remodeling of the neurovascular unit, which integrates neuronal, glial, and vascular functions. The process encompasses inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f070ccfba21aef762d0b5bc0d75eba0
https://doi.org/10.36255/exonpublications.cerebralischemia.2021.neurovascularreactivity
https://doi.org/10.36255/exonpublications.cerebralischemia.2021.neurovascularreactivity
Autor:
Egor Dzyubenko, Daniel Manrique-Castano, Matthias Pillath-Eilers, Paraskevi Vasileiadou, Jacqueline Reinhard, Andreas Faissner, Dirk M Hermann
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 110
Cellular responses in glia play a key role in regulating brain remodeling post-stroke. However, excessive glial reactivity impedes post-ischemic neuroplasticity and hampers neurological recovery. While damage-associated molecular patterns and activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f698c15d42358800c3a4481ffccc6fac
https://pubmed.ncbi.nlm.nih.gov/35430380
https://pubmed.ncbi.nlm.nih.gov/35430380
This protocol implements the culture of Human Brain Vascular Pericytes (HBVP) and is suitable for several research techniques, including immunohistochemistry, flow cytometry, and Protein or RNA analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53867c788e1e32d09a0ba416bd929c79
https://doi.org/10.17504/protocols.io.brxjm7kn
https://doi.org/10.17504/protocols.io.brxjm7kn