Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Daniel M. Treisman"'
Autor:
Yinghua Li, Bo Li, Wei Li, Yuan Wang, Seçkin Akgül, Daniel M. Treisman, Kevin A. Heist, Brianna R. Pierce, Benjamin Hoff, Cheng-Ying Ho, David O. Ferguson, Alnawaz Rehemtulla, Siyuan Zheng, Brian D. Ross, Jun Z. Li, Yuan Zhu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Recent studies suggest spatial segregation of tumor initiation and manifestation in IDH-WT glioblastomas. Here, the authors use serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree buildin
Externí odkaz:
https://doaj.org/article/4bdb60bfd8b842efb554542d31c8e854
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
Pediatric low-grade gliomas (pLGGs) are almost universally driven by abnormal activation of RAS-mediated MEK-ERK/MAPK signaling pathway. pLGGs predominantly occur in children, suggesting that they originate in an ERK-dependent neural stem/progenitor
Externí odkaz:
https://doaj.org/article/420554039c47499fbe46f89c916a56e8
Autor:
Seçkin Akgül, Yinghua Li, Siyuan Zheng, Marcel Kool, Daniel M. Treisman, Chaoyang Li, Yuan Wang, Susanne Gröbner, Tsuneo Ikenoue, Yiping Shen, Sandra Camelo-Piragua, Gerald Tomasek, Sebastian Stark, Vinay Guduguntla, James F. Gusella, Kun-Liang Guan, Stefan M. Pfister, Roel G.W. Verhaak, Yuan Zhu
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 463-478.e5 (2018)
Summary: Most human cancers arise from stem and progenitor cells by the sequential accumulation of genetic and epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here, we show that a single p53 mu
Externí odkaz:
https://doaj.org/article/143b6d91cb50469b8a9f91943f81e8a4
Autor:
Paul A. Clark, Mari Iida, Daniel M. Treisman, Haviryaji Kalluri, Sathyapriya Ezhilan, Michael Zorniak, Deric L. Wheeler, John S. Kuo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 5, Pp 420-428 (2012)
Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumorigenesis. However, molecular agents targeting EGFR have demonstrated minimal efficacy in clinical trials, suggesting the existence of GBM resistance m
Externí odkaz:
https://doaj.org/article/532e2b057b8e4ce59b1099ff33e191ea
Publikováno v:
Mol Cell Oncol
Pediatric low-grade gliomas (pLGGs) are almost universally driven by abnormal activation of RAS-mediated MEK-ERK/MAPK signaling pathway. pLGGs predominantly occur in children, suggesting that they originate in an ERK-dependent neural stem/progenitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a84361b26bc5321c747902032b7f533
https://pubmed.ncbi.nlm.nih.gov/35419473
https://pubmed.ncbi.nlm.nih.gov/35419473
Autor:
Daniel M. Treisman, Wei Li, Bo Li, Benjamin A. Hoff, Alnawaz Rehemtulla, Siyuan Zheng, Brianna R. Pierce, Yinghua Li, Yuan Zhu, Yuan Wang, Seckin Akgul, Brian D. Ross, David O. Ferguson, Jun Li, Kevin A. Heist, Cheng-Ying Ho
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
Recent characterization of spatiotemporal genomic architecture of IDH-wild-type multifocal glioblastomas (M-GBMs) suggests a clinically unobserved common-ancestor (CA) with a less aggressive phenotype, generating highly genetically divergent malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1c99206120994c90914c519e533b50
https://doaj.org/article/4bdb60bfd8b842efb554542d31c8e854
https://doaj.org/article/4bdb60bfd8b842efb554542d31c8e854
Publikováno v:
Neuromolecular medicine. 24(1)
While most Sonic Hedgehog-associated medulloblastomas (SHH-MBs) respond to therapeutic intervention, radiation therapy often causes deleterious long-term neurocognitive defects, especially in infants and young children. To limit neurological comorbid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3dec9ad866b75ef046e91bd7e126c2
https://pubmed.ncbi.nlm.nih.gov/34165693
https://pubmed.ncbi.nlm.nih.gov/34165693
Autor:
Shayne F. Andrew, Matthew K. Krause, Emmanuelle S. Jecrois, Austin Friend, Jingwen Jiang, Yinghua Li, Yuan Zhu, Daphine Muguyo, Francisco M Nadal-Nicolás, Brianna R. Pierce, Wei Li, Hongmei Mao, Sharon Huynh, Yuan Wang, Steven F Stasheff, Miriam Bornhorst, Roger J. Packer, Daniel M. Treisman, Hui Zong, Wang Zheng
Publikováno v:
Developmental cell. 56(20)
The mechanism of vulnerability to pediatric low-grade gliomas (pLGGs)-the most common brain tumor in children-during development remains largely unknown. Using mouse models of neurofibromatosis type 1 (NF1)-associated pLGGs in the optic pathway (NF1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19bf0a68f78ffeeb46836bbdc994324
https://pubmed.ncbi.nlm.nih.gov/34699786
https://pubmed.ncbi.nlm.nih.gov/34699786
Autor:
Daniel M. Treisman, Guillermina Lozano, Chaoyang Li, Yinghua Li, Gerald J. Tomasek, Xiaoyan Zheng, Yuan Zhu, Marcel Kool, Brianna R. Pierce, Andrew P. Chervenak
Publikováno v:
Neuro-Oncology Advances
Background High-intensity therapy effectively treats most TP53 wild-type (TP53-WT) Sonic Hedgehog-subgroup medulloblastomas (SHH-MBs), but often cause long-term deleterious neurotoxicities in children. Recent clinical trials investigating reduction/d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171be475f21a9d4d5f2fad1fe99718d1
https://pubmed.ncbi.nlm.nih.gov/31763624
https://pubmed.ncbi.nlm.nih.gov/31763624
Autor:
Tsuneo Ikenoue, Marcel Kool, Yiping Shen, Daniel M. Treisman, Kun-Liang Guan, Yinghua Li, Susanne Gröbner, Chaoyang Li, Roel G.W. Verhaak, Vinay Guduguntla, James F. Gusella, Gerald J. Tomasek, Seckin Akgul, Stefan M. Pfister, Siyuan Zheng, Yuan Wang, Sandra Camelo-Piragua, Sebastian Stark, Yuan Zhu
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 463-478.e5 (2018)
Cell reports
Cell reports, vol 24, iss 2
Cell reports
Cell reports, vol 24, iss 2
SUMMARY Most human cancers arise from stem and progenitor cells by the sequential accumulation of genetic and epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here, we show that a single p53 mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b5ee24979bf18b7ada15d773bf96da
https://doi.org/10.1016/j.celrep.2018.06.050
https://doi.org/10.1016/j.celrep.2018.06.050