Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel M. Sze"'
Autor:
Andrew Spencer, Nola Kennedy, Phoebe Joy Ho, Ross D. Brown, Douglas E. Joshua, Esther Aklilu, Shihong Yang, Daniel M. Sze, John Gibson, Karieshma Kabani
Publikováno v:
Leukemia and Lymphoma. :1-5
The expanded T cell clones are associated with a prolonged survival in patients with multiple myeloma. We sought to confirm this prognostic significance in a multicenter patient cohort and investigate the effect of thalidomide on clones and T regulat
Autor:
P. Joy Ho, Derek N.J. Hart, Belinda Pope, John Gibson, Allan Murray, Ross Brown, Daniel M. Sze, Doug Joshua
Publikováno v:
British Journal of Haematology. 125:743-748
The poor response to immunotherapy in patients with multiple myeloma (MM) indicates that a better understanding of any defects in the immune response in these patients is required before effective therapeutic strategies can be developed. Recently we
Autor:
Douglas E. Joshua, Belinda Pope, Daniel M. Sze, Ross D. Brown, Allan Murray, L. Barrow, John Gibson, Derek N.J. Hart
Publikováno v:
Leukemialymphoma. 44(12)
The optimal conditions required to harvest dendritic cells (DC) for immunotherapy were investigated in a series of preliminary investigations using peripheral blood stem cell (PBSC) harvests and blood from patients with myeloma. There was no differen
Autor:
Belinda Pope, Ross D. Brown, P. Joy Ho, Derek N.J. Hart, Daniel M. Sze, Warren Esdale, Doug Joshua, Allan Murray, John Gibson
Publikováno v:
Blood. 98(10)
Limited response to idiotype vaccination in patients with myeloma suggests that there is a need to develop better immunotherapy strategies. It has been determined that the number of high-potency CMRF44(+)CD14(-)CD19(-) dendritic cells (DCs) in the bl
Publikováno v:
Cancer Research. 71:2707-2707
Dendritic Cells play a pivotal role in the regulation of tumour-specific immune responses. However, cancer-associated microenvironment may adversely affect DC-related immune-surveillance system leading to defective DCs, which fail to up-regulate impo
Autor:
Shihong Yang, Winfried S. Wels, Daniel M. Sze, Joy Ho, Ross D. Brown, Douglas E. Joshua, John Gibson, Xin An
Publikováno v:
Blood. 106:5104-5104
Multiple Myeloma (MM) is a B cell neoplasm in which malignant plasma cells accumulate in the bone marrow and produce excessive amounts of a monoclonal immunoglobulin. Among the large number of antigens expressed by plasma cells, CD38 is one of the hi
Autor:
Phoebe Joy Ho, Ross D. Brown, Allan Murray, Andrew Spencer, Douglas E. Joshua, John Gibson, Daniel M. Sze
Publikováno v:
Blood. 106:5108-5108
Although thalidomide has been reported to increase T cell activity and NK cell cytotoxicity in the blood of patients with multiple myeloma (MM) it is not known whether thalidomide stimulates tumour-specific T cells or causes a general lymphocytosis.
Autor:
Shihong Yang, Joy Ho, Devanshi Seth, Daniel M. Sze, Ross D. Brown, Xin An, Tetsuo Yamagishi, Douglas E. Joshua, Warren Kaplan, John Gibson
Publikováno v:
Blood. 106:3418-3418
Different stages of differentiation of CD8 T cells based on the expression of costimulatory receptors - CD28 and CD27 has been previously described (Nature Medicine8:379, 2002). Specifically, CD8 T cells that are CD28−CD27− are designated as the