Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Daniel M. Rosenbaum"'
Autor:
Daniel L. Kober, Marley C. Caballero Van Dyke, Jennifer L. Eitson, Ian N. Boys, Matthew B. McDougal, Daniel M. Rosenbaum, John W. Schoggins
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT The rapid evolution of SARS-CoV-2 variants highlights the need for new therapies to prevent disease spread. SARS-CoV-2, like SARS-CoV-1, uses the human cell surface protein angiotensin-converting enzyme 2 (ACE2) as its native receptor. Here,
Externí odkaz:
https://doaj.org/article/bb44b7e8a55249a1bd0f9458bb7da61a
Autor:
Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K. De Brabander, Daniel M. Rosenbaum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract The OX2 orexin receptor (OX2R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in humans. Antagonism of OX2R is a proven therapeutic strategy for insomnia drugs, and agoni
Externí odkaz:
https://doaj.org/article/9405c8a136a547eebb4d8f70de895b56
Autor:
Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K. De Brabander, Daniel M. Rosenbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/9a0f713de8cb43e89a329843e0e714da
Publikováno v:
Proceedings of the National Academy of Sciences. 120
FFAR1 is a G-protein-coupled receptor (GPCR) that responds to circulating free fatty acids to enhance glucose-stimulated insulin secretion and release of incretin hormones. Due to the glucose-lowering effect of FFAR1 activation, potent agonists for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47ba7c36202385afca43488caaf6ab30
https://doi.org/10.1073/pnas.2219569120
https://doi.org/10.1073/pnas.2219569120
Autor:
Yu Sun, Alok Ranjan, Ryan Tisdale, Shun‐Chieh Ma, Sunmee Park, Meghan Haire, Jasmine Heu, Stephen R. Morairty, Xiaoyu Wang, Daniel M. Rosenbaum, Noelle S. Williams, Jef K. De Brabander, Thomas S. Kilduff
Publikováno v:
Journal of Sleep Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb9a7503b0b4bf36cb1145b9f1dbd047
https://doi.org/10.1111/jsr.13839
https://doi.org/10.1111/jsr.13839
Autor:
Yu Sun, Alok Ranjan, Ryan Tisdale, Shun-Chieh Ma, Sunmee Park, Meghan Haire, Jasmine Heu, Stephen R. Morairty, Xiaoyu Wang, Daniel M. Rosenbaum, Noelle S. Williams, Jef K. De Brabander, Thomas S. Kilduff
The sleep disorder Narcolepsy, a hypocretin deficiency disorder thought to be due to degeneration of hypothalamic hypocretin/orexin neurons, is currently treated symptomatically. We evaluated the efficacy of two small molecule hypocretin/orexin recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c515e44c161fd25461eb167fcdb30629
https://doi.org/10.1101/2022.12.09.519796
https://doi.org/10.1101/2022.12.09.519796
Autor:
Karthik Ramesh, Daniel M. Rosenbaum
Publikováno v:
British Journal of Pharmacology. 179:3487-3495
The cannabinoid CB1 receptor is the most abundant G protein coupled receptor (GPCR) in the central nervous system, which mediates the functional response to endocannabinoids and Cannabis compounds. A variety of ligands for CB1 receptors have been dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80dbc5a02cf7191d677345cb2b5c5766
https://doi.org/10.1111/bph.15627
https://doi.org/10.1111/bph.15627
Autor:
Lindsay D Clark, Igor Dikiy, Karen Chapman, Karin EJ Rödström, James Aramini, Michael V LeVine, George Khelashvili, Søren GF Rasmussen, Kevin H Gardner, Daniel M Rosenbaum
Publikováno v:
eLife, Vol 6 (2017)
GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands. Yet there is no experimental evidence for how sidechain dynamics control allosteric transi
Externí odkaz:
https://doaj.org/article/0e6a3d7fea4c4ae28c73643d606afa6b
Autor:
Jin Zhou, Jie Li, Daniel M Rosenbaum, Jian Zhuang, Carrie Poon, Pu Qin, Katrina Rivera, John Lepore, Robert N Willette, Erding Hu, Frank C Barone
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184049 (2017)
There is interest in pharmacologic preconditioning for end-organ protection by targeting the HIF system. This can be accomplished by inhibition of prolyl 4-hydroxylase (PHD). GSK360A is an orally active PHD inhibitor that has been previously shown to
Externí odkaz:
https://doaj.org/article/cb1b846706204171ab5a6168e334d25c
Autor:
Shili Li, Daniel L. Kober, Shimeng Xu, Bilkish Bajaj, Daniel M. Rosenbaum, Guosheng Liang, Arun Radhakrishnan
Publikováno v:
Proc Natl Acad Sci U S A
Lipid homeostasis in animal cells is maintained by sterol regulatory element-binding proteins (SREBPs), membrane-bound transcription factors whose proteolytic activation requires the cholesterol-sensing membrane protein Scap. In endoplasmic reticulum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc84613ccb860781c514c1d4d67d37a
https://doi.org/10.1073/pnas.2018578117
https://doi.org/10.1073/pnas.2018578117