Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Daniel M. Quinn"'
Publikováno v:
Molecules, Vol 22, Iss 9, p 1464 (2017)
Organophosphorus agents are potent inhibitors of acetylcholinesterase. Inhibition involves successive chemical events. The first is phosphylation of the active site serine to produce a neutral adduct, which is a close structural analog of the acylati
Externí odkaz:
https://doaj.org/article/6c380cdf88f54fc88ef697e72c302536
Autor:
Qi Guo, Christopher M. Cheatum, Andrew L. Lee, Chethya Ranasinghe, Paul J. Sapienza, Amnon Kohen, Daniel M. Quinn
Publikováno v:
Journal of the American Chemical Society. 139:17405-17413
Isotopically labeled enzymes (denoted as "heavy" or "Born-Oppenheimer" enzymes) have been used to test the role of protein dynamics in catalysis. The original idea was that the protein's higher mass would reduce the frequency of its normal-modes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5921198d771644d0f1d0363e2775cc
https://doi.org/10.1021/jacs.7b08359
https://doi.org/10.1021/jacs.7b08359
Publikováno v:
Archives of Biochemistry and Biophysics. 632:11-19
Thymidylate is synthesized de novo in all living organisms for replication of genomes. The chemical transformation is reductive methylation of deoxyuridylate at C5 to form deoxythymidylate. All eukaryotes including humans complete this well-understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c4147139ac6099064eb20dfde765de
https://doi.org/10.1016/j.abb.2017.08.011
https://doi.org/10.1016/j.abb.2017.08.011
Autor:
Joseph J. Topczewski, Daniel M. Quinn, Jason A. Morrill, Nilanthi Yasapala, Alexander M. Lodge
Publikováno v:
Journal of Molecular Graphics and Modelling. 62:181-189
Among the most toxic substances known are the organophosphorus (OP) compounds used as pesticides and chemical warfare agents. Owing to their high toxicity there is a number of efforts underway to develop effective therapies for OP agent exposure. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec79f986ffa7037e0cb20095a1e6d32e
https://doi.org/10.1016/j.jmgm.2015.09.016
https://doi.org/10.1016/j.jmgm.2015.09.016
Publikováno v:
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 22, Iss 9, p 1464 (2017)
Molecules, Vol 22, Iss 9, p 1464 (2017)
Organophosphorus agents are potent inhibitors of acetylcholinesterase. Inhibition involves successive chemical events. The first is phosphylation of the active site serine to produce a neutral adduct, which is a close structural analog of the acylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a912e5e9aa465c307c7accba73c748a
http://europepmc.org/articles/PMC6151809
http://europepmc.org/articles/PMC6151809
Autor:
Daniel M. Quinn
Publikováno v:
Journal of Medicinal Chemistry. 61:7032-7033
Organophosphorus agents such as sarin and soman that phosphylate the active site serine of the enzyme acetylcholinesterase are notorious and pernicious, not only because they have been used by tyrants to effect mass murder of their own populations bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0eef6a9c6b5e2a766a1f910aeb4ec5f
https://doi.org/10.1021/acs.jmedchem.8b01122
https://doi.org/10.1021/acs.jmedchem.8b01122
Autor:
Pedrom M. Keshavarzi, Joseph J. Topczewski, Sumana N. Yasapala, Maurice K. Payne, Alexander M. Lodge, Daniel M. Quinn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5786-5789
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cbd835e3f6a7361c583417477d1474
https://doi.org/10.1016/j.bmcl.2013.09.008
https://doi.org/10.1016/j.bmcl.2013.09.008
Autor:
Daniel M. Quinn, Markus Wohlgenannt, Adam B. Brummett, Ned B. Bowden, Jun Yoo, Tyler A. Graf, Ran Lin
Publikováno v:
Macromolecules. 45:8193-8200
The synthesis and some of the physical properties of the first poly(disulfidediamines) are reported. The disulfidediamine functional group (R2NSSNR2) possesses a disulfide bond in a unique environment that leads to a low bond dissociation energy (cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feae8a1c202c9e4540372c2fc2b8de06
https://doi.org/10.1021/ma3017103
https://doi.org/10.1021/ma3017103
Publikováno v:
Chemico-Biological Interactions. 187:124-127
beta-Secondary deuterium isotope effects have been measured for equine serum butyrylcholinesterase-catalyzed hydrolysis of acetyl-L(3)-thiocholine (L=H or (2)H). The dependencies of initial rates on isotopic substrate concentrations show close adhere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7637b13bd9de69134a285cfb4adb7f
https://doi.org/10.1016/j.cbi.2010.05.007
https://doi.org/10.1016/j.cbi.2010.05.007
The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and
