Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Daniel M. Purdham"'
Autor:
Xiaohong Tracey Gan, Ganjian Zhao, Cathy X Huang, Adrianna C Rowe, Daniel M Purdham, Morris Karmazyn
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74235 (2013)
The recently-identified fat mass and obesity-associated (FTO) protein is associated with various physiological functions including energy and body weight regulation. Ubiquitously expressed, FTO was identified in heart homogenates although its functio
Externí odkaz:
https://doaj.org/article/cf148003ba164abaa3aa9d693a340d32
Publikováno v:
Therapeutic Advances in Cardiovascular Disease
The nonvitamin K antagonist oral anticoagulants (NOACs), also referred to as direct oral anticoagulants (DOACs), dabigatran, apixaban, edoxaban, and rivaroxaban, have emerged as effective alternatives to vitamin K antagonists (VKAs) across several in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d6d1d7d7960f6deba4e8d8b0a417f1
https://doi.org/10.1177/1753944717714921
https://doi.org/10.1177/1753944717714921
Autor:
Yan Deschaintre, Peter L. Gross, Alan Bell, Michael Heffernan, Jean-Francois Roux, Ashfaq Shuaib, Daniel M. Purdham
Publikováno v:
The American journal of cardiology. 117(7)
This national chart audit of 7,019 patients with nonvalvular atrial fibrillation (AF) from 735 primary care physician practices sought to examine the management of Canadian patients with AF through an evidence-based, guideline-recommended approach. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e6f35a15d6ac279cfbf1a907cd686d
https://pubmed.ncbi.nlm.nih.gov/26879070
https://pubmed.ncbi.nlm.nih.gov/26879070
Autor:
Sabzali Javadov, Morris Karmazyn, Venkatesh Rajapurohitam, Subrata Chakrabarti, Daniel M. Purdham, Asad Zeidan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1075-1084
Various cardiovascular pathologies are associated with vascular smooth muscle cell (VSMC) hypertrophy and elevated plasma leptin levels. We used the rat portal vein (RPV) cultured for three days to investigate the effect of mechanical stretch on auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1088679bf2a8ced077bef101e7d1160a
https://doi.org/10.1124/jpet.105.091561
https://doi.org/10.1124/jpet.105.091561
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H2877-H2884
Leptin, the 16-kDa peptide hormone product of the ob gene, is produced primarily by adipocytes and was initially thought to exert its effects exclusively through actions on the hypothalamus via distinct leptin receptors termed OB-R. However, recent d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b919b4d2cda0b01c49de941b657a01ae
https://doi.org/10.1152/ajpheart.00499.2004
https://doi.org/10.1152/ajpheart.00499.2004
Autor:
Cathy Huang, Xiaohong Tracey Gan, Ganjian Zhao, Daniel M. Purdham, Morris Karmazyn, Adrianna C. Rowe
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74235 (2013)
PLoS ONE
PLoS ONE
The recently-identified fat mass and obesity-associated (FTO) protein is associated with various physiological functions including energy and body weight regulation. Ubiquitously expressed, FTO was identified in heart homogenates although its functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc2af3b180d477cfd4b705d7a026d02
http://europepmc.org/articles/PMC3760875?pdf=render
http://europepmc.org/articles/PMC3760875?pdf=render
Publikováno v:
Cardiovascular research. 79(2)
Adipokines represent a family of proteins released by adipocytes that affect various biological processes including metabolism, satiety, inflammation, and cardiovascular function. The first adipokine to be identified is leptin, a product of the obesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4632513853040b9414cbe75d0f14296
https://pubmed.ncbi.nlm.nih.gov/18474523
https://pubmed.ncbi.nlm.nih.gov/18474523
Autor:
Daniel M. Purdham, Venkatesh Rajapurohitam, Garrett J. Gross, Morris Karmazyn, Cathy Huang, Asad Zeidan
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 295(1)
The 16 kDa adipokine leptin has been shown to exert direct hypertrophic effects on cultured cardiomyocytes although its role as an endogenous contributor to postinfarction remodeling and heart failure has not been determined. We therefore investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b19c6918c7443710ea79f4168f0747a
https://pubmed.ncbi.nlm.nih.gov/18469142
https://pubmed.ncbi.nlm.nih.gov/18469142
Publikováno v:
Signal Transduction in the Cardiovascular System in Health and Disease ISBN: 9780387095516
Since its initial discovery as a satiety product of the obesity gene, leptin has received extensive attention especially in terms of its potential role in appetite suppression and regulation of energy expenditure. The primary sources of leptin produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61cc7e85d6b91232d01ff4a82846b305
https://doi.org/10.1007/978-0-387-09552-3_20
https://doi.org/10.1007/978-0-387-09552-3_20
Publikováno v:
Circulation. 116
Introduction: Leptin, a 16 kDa product of the obesity gene, has been shown to be elevated in patients with heart failure. Recently we demonstrated that leptin induces hypertrophy in cultured cardiomyocytes, however the molecular mechanisms underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa3797cda3428bbf5cd4756a33f5bc97
https://doi.org/10.1161/circ.116.suppl_16.ii_274
https://doi.org/10.1161/circ.116.suppl_16.ii_274