Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Daniel M. Houslay"'
Autor:
Krishna C. Yalla, Elaine Huston, George S. Baillie, Elaine V. Hill, Miles D. Houslay, Louisa C.Y. Lee, David Henderson, Catherine L. Sheppard, Daniel M. Houslay, Allan J. Dunlop, Lynne S. Cairns, Diana F. Anthony
Publikováno v:
Cellular Signalling. 26:1958-1974
In Rat-1 cells, the dramatic decrease in the levels of both intracellular cyclic 3'5' adenosine monophosphate (cyclic AMP; cAMP) and in the activity of cAMP-activated protein kinase A (PKA) observed in mitosis was paralleled by a profound increase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12908b4e4d0dd5566261a6d7a493242
https://doi.org/10.1016/j.cellsig.2014.04.023
https://doi.org/10.1016/j.cellsig.2014.04.023
Autor:
Tamara Chessa, Julian Downward, Karen E. Anderson, Suhasini Kulkarni, Jonathan M. Backer, Ralph Fritsch, Daniel M. Houslay, Len R. Stephens, Phillip T. Hawkins
Publikováno v:
Science Signaling. 9
Class I phosphoinositide 3-kinases (PI3Ks) catalyze production of the lipid messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3), which plays a central role in a complex signaling network regulating cell growth, survival, and movement. This netw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0e6662156f8a780901ca32bd34e44d
https://doi.org/10.1126/scisignal.aae0453
https://doi.org/10.1126/scisignal.aae0453
Publikováno v:
Molecular Cell. 44:476-490
Homeostatic control of oxygen availability allows cells to survive oxygen deprivation. Although the transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator of the hypoxic response, the upstream mechanisms required for its st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f323e74950bb867c3b4b4f9e8873fe
https://doi.org/10.1016/j.molcel.2011.08.033
https://doi.org/10.1016/j.molcel.2011.08.033
Autor:
George S. Baillie, Derek A. Wallace, Elaine V. Hill, Miles D. Houslay, Diana F. Anthony, David Henderson, Daniel M. Houslay, Kirsty F. MacKenzie, J. Simon C. Arthur
Publikováno v:
Biochemical Journal. 435:755-769
cAMP-specific PDE (phosphodiesterase) 4 isoforms underpin compartmentalized cAMP signalling in mammalian cells through targeting to specific signalling complexes. Their importance is apparent as PDE4 selective inhibitors exert profound anti-inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddeb00950c014c5de7c13ad40a656cc7
https://doi.org/10.1042/bj20101184
https://doi.org/10.1042/bj20101184
Autor:
Jana Bogum, Robert W. Allcock, Elisabeth K. Martin, Elaine Huston, Tracy Riddell, Daniel M. Houslay, Frank Christian, Miles D. Houslay, Zhong Jiang, Barbara Lindsay, Achamma Abraham, Enno Klussmann, George S. Baillie, David R. Adams, Jonathan P. Day, Sebastian Sookup, Georgina M. Rosair, Robert L. Rae, Diana F. Anthony
Publikováno v:
Journal of Medicinal Chemistry. 54:3331-3347
A survey of PDE4 inhibitors reveals that some compounds trigger intracellular aggregation of PDE4A4 into accretion foci through association with the ubiquitin-binding scaffold protein p62 (SQSTM1). We show that this effect is driven by inhibitor occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fb40712efded0dfb998a6028221ddc
https://doi.org/10.1021/jm200070e
https://doi.org/10.1021/jm200070e