Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Daniel M. Fass"'
Autor:
Rachel Tesla, Charlotte Guhl, Gordon C. Werthmann, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M. Fass, Zachary Rosenthal, Stephen J. Haggarty, Noelle S. Williams, Bruce A. Posner, Joseph M. Ready, Joachim Herz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia. The mechanisms linking frontotemporal dementia pathogenesis to progranulin deficiency are not well understood, and there is curr
Externí odkaz:
https://doaj.org/article/c7ffddc3386d4b01812406f15f938067
Autor:
Zachary C. Rosenthal, Daniel M. Fass, N. Connor Payne, Angela She, Debasis Patnaik, Krista M. Hennig, Rachel Tesla, Gordon C. Werthmann, Charlotte Guhl, Surya A. Reis, Xiaoyu Wang, Yueting Chen, Michael Placzek, Noelle S. Williams, Jacob Hooker, Joachim Herz, Ralph Mazitschek, Stephen J. Haggarty
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-29 (2024)
Abstract Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently no disease-modifying treatment options available. Mutations in GRN are one of the most common genetic causes of FTD, near ubiquitously resulting in pro
Externí odkaz:
https://doaj.org/article/0ce6be333ade4397a3f955c44b12062e
Autor:
Chialin Cheng, Surya A. Reis, Emily T. Adams, Daniel M. Fass, Steven P. Angus, Timothy J. Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T. Wang, Debasis Patnaik, Roberta L. Beauchamp, Danielle A. Feldman, M. Catarina Silva, Mriganka Sur, Gary L. Johnson, Vijaya Ramesh, Bruce L. Miller, Sally Temple, Kenneth S. Kosik, Bradford C. Dickerson, Stephen J. Haggarty
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons u
Externí odkaz:
https://doaj.org/article/dbd7b9c359124c2ab41cec4cd38e2e30
Autor:
Marina Kovalenko, Serkan Erdin, Marissa A Andrew, Jason St Claire, Melissa Shaughnessey, Leroy Hubert, João Luís Neto, Alexei Stortchevoi, Daniel M Fass, Ricardo Mouro Pinto, Stephen J Haggarty, John H Wilson, Michael E Talkowski, Vanessa C Wheeler
Publikováno v:
eLife, Vol 9 (2020)
Somatic expansion of the Huntington’s disease (HD) CAG repeat drives the rate of a pathogenic process ultimately resulting in neuronal cell death. Although mechanisms of toxicity are poorly delineated, transcriptional dysregulation is a likely cont
Externí odkaz:
https://doaj.org/article/7ec6f42abf9f427c8434769cf8737ee8
Autor:
Daniel M. Fass, Roberta L. Beauchamp, Steven P. Angus, Chialin Cheng, Kenneth S. Kosik, Timothy J. Stuhlmiller, Bradford C. Dickerson, Bruce L. Miller, Debasis Patnaik, Danielle A. Feldman, Jared I Richardson, Stephen J. Haggarty, Hailey Olafson, Surya A. Reis, Mriganka Sur, Gary L. Johnson, Vijaya Ramesh, Eric T. Wang, Sally Temple, Emily T Adams, M. Catarina Silva
Publikováno v:
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons ultimately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648e69bd4afba94c17b3f3502a46e0b7
http://europepmc.org/articles/PMC8382845
http://europepmc.org/articles/PMC8382845
Autor:
Carlos Moreno-Yruela, Chialin Cheng, Christian A. Olsen, Daniel M. Fass, Joachim Herz, Stephen J. Haggarty
Publikováno v:
Moreno-Yruela, C, Fass, D M, Cheng, C, Herz, J, Olsen, C A & Haggarty, S J 2019, ' Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression ', A C S Chemical Neuroscience, vol. 10, no. 8, pp. 3769-3777 . https://doi.org/10.1021/acschemneuro.9b00281
ACS Chem Neurosci
ACS Chem Neurosci
Histone deacetylases (HDACs) are enzymes involved in the epigenetic control of gene expression. A handful of HDAC inhibitors have been approved for the treatment of cancer, and HDAC inhibition has also been proposed as a novel therapeutic strategy fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1955d103b83b2645def8b6fc79d7e25
https://doi.org/10.1021/acschemneuro.9b00281
https://doi.org/10.1021/acschemneuro.9b00281
Autor:
Frederick A Schroeder, Michael C Lewis, Daniel M Fass, Florence F Wagner, Yan-Ling Zhang, Krista M Hennig, Jennifer Gale, Wen-Ning Zhao, Surya Reis, Douglas D Barker, Erin Berry-Scott, Sung Won Kim, Elizabeth L Clore, Jacob M Hooker, Edward B Holson, Stephen J Haggarty, Tracey L Petryshen
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71323 (2013)
Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary--albeit often ineffective--treatment method, has remained largely u
Externí odkaz:
https://doaj.org/article/f98bfbbf4c0c4abda75478a1de4329d5
Autor:
Ricardo Mouro Pinto, Marissa A Andrew, Michael E. Talkowski, João Luís Neto, Daniel M. Fass, Jason St. Claire, Melissa Shaughnessey, Marina Kovalenko, John H. Wilson, Alexei Stortchevoi, Stephen J. Haggarty, Leroy Hubert, Vanessa C. Wheeler, Serkan Erdin
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Somatic expansion of the Huntington’s disease (HD) CAG repeat drives the rate of a pathogenic process ultimately resulting in neuronal cell death. Although mechanisms of toxicity are poorly delineated, transcriptional dysregulation is a likely cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bab383dbf15df6044f9404456e723d
https://elifesciences.org/articles/55911
https://elifesciences.org/articles/55911
Autor:
Leroy Hubert, Stephen J. Haggarty, Ricardo Mouro Pinto, Vanessa C. Wheeler, Jason St. Claire, Serkan Erdin, Melissa Shaughnessey, Marina Kovalenko, João Luís Neto, John H. Wilson, Marissa A Andrew, Alexei Stortchevoi, Daniel M. Fass, Michael E. Talkowski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5f26d108cb7e0b3edc8ee31be3f7a3b
https://doi.org/10.7554/elife.55911.sa2
https://doi.org/10.7554/elife.55911.sa2
Autor:
David A. Sweetser, Michael E. Talkowski, Ting Fu, Wen-Ning Zhao, Daniel M. Fass, James F. Gusella, Alexei Stortchevoi, Serkan Erdin, Stephen J. Haggarty, Diane Lucente, Krista M. Hennig, Steven D. Sheridan, Jannine D. Cody
Publikováno v:
Complex Psychiatry. 3:53-71
Genetic variation within the transcription factor TCF4 locus can cause the intellectual disability and developmental disorder Pitt-Hopkins syndrome (PTHS), whereas single-nucleotide polymorphisms within noncoding regions are associated with schizophr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8472ea7e1dcb90e84692413a766bf21d
https://doi.org/10.1159/000475666
https://doi.org/10.1159/000475666