Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Daniel M. Dorsa"'
Publikováno v:
The Journal of Neuroscience. 33:16158-16169
Premature and long-term ovarian hormone loss following ovariectomy (OVX) is associated with cognitive impairment. This condition is prevented by estradiol (E2) therapy when initiated shortly following OVX but not after substantial delay. To determine
Publikováno v:
Neuroscience. 153:751-761
Estrogen receptors can activate transcription in the nucleus, and activate rapid signal transduction cascades in the cytosol. Multiple reports identify estrogen receptors at the plasma membrane, while others document the dynamic responses of estrogen
Autor:
A.J. Mhyre, Daniel M. Dorsa
Publikováno v:
Neuroscience. 138:851-858
The aging process is known to coincide with a decline in circulating sex hormone levels in both men and women. Due to an increase in the average lifespan, a growing number of post-menopausal women are now receiving hormone therapy for extended period
Publikováno v:
Endocrine. 29:199-208
Numerous preclinical studies suggest that gonadal steroids, particularly estrogen, may be neuroprotective against insult or disease progression. This paper reviews the mechanisms contributing to estrogen-mediated neuroprotection. Rapid signaling path
Publikováno v:
Neuroscience. 133:343-352
Physiological doses of 17-β Estradiol (E 2 ) rapidly induce mitogen-activated protein kinase (MAPK) phosphorylation in a variety of cell culture and tissue explant preparations. Rapid MAPK phosphorylation has been implicated as a critical step in es
Autor:
Robert A. Shapiro, Christian B. Wade, Jennifer L. Fitzpatrick, Amy L. Mize, Julie A. Harris, Daniel M. Dorsa
Publikováno v:
Journal of Neurochemistry. 82:674-682
It is well documented that estrogen can activate rapid signaling pathways in a variety of cell types. These non-classical effects of estrogen have been reported to be important for cell survival after exposure to a variety of neurotoxic insults. Sinc
Publikováno v:
Proceedings of the National Academy of Sciences. 98:10451-10456
Motor stereotypies are abnormally repetitive behaviors that can develop with excessive dopaminergic stimulation and are features of some neurologic disorders. To investigate the mechanisms required for the induction of stereotypy, we examined the res
Publikováno v:
The Journal of Neuroscience. 21:2546-2552
The oxytocin receptor (OTR) is differentially expressed in the CNS. Because there are multiple mechanisms by which the OTR can be transcriptionally induced, we hypothesized that differences in OTR expression may be explained by activation of distinct
Publikováno v:
Endocrinology. 141:4056-4064
Neuronal expression of vasopressin messenger RNA (mRNA) and peptide has been shown to be estrogen dependent. A 5.5-kb genomic DNA fragment, 5′ of the AVP coding region, was used in luciferase reporter assays to measure transcriptional activation by
Publikováno v:
Journal of Neurocytology. 29:367-374
A review of the literature reveals an impressively broad spectrum of effects of the hormone estrogen in the CNS. One of the more recently documented is the ability of estrogen to protect neurons from cell death associated with a variety of insults. W