Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Daniel M. DeLaughter"'
Autor:
Daniel Reichart, Gregory A. Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M. Gorham, Justin J. Curran, Aditya Raguram, Daniel M. DeLaughter, David A. Conner, Júlia D. C. Marsiglia, Sajeev Kohli, Lukas Chmatal, David C. Page, Nerea Zabaleta, Luk Vandenberghe, David R. Liu, Jonathan G. Seidman, Christine Seidman
Publikováno v:
Nature Medicine. 29:412-421
Dominant missense pathogenic variants in cardiac myosin heavy chain cause hypertrophic cardiomyopathy (HCM), a currently incurable disorder that increases risk for stroke, heart failure and sudden cardiac death. In this study, we assessed two differe
Autor:
Qi Zhang, Seong Won Kim, Joshua M. Gorham, Daniel M. DeLaughter, Tarsha Ward, Christine E. Seidman, Jonathan G. Seidman
Publikováno v:
Current protocols. 2(10)
This protocol describes a robust pipeline for simultaneously analyzing multiple samples by single-nucleus (sn)RNA-seq. cDNA obtained from each single sample are labeled with the same lipid-coupled oligonucleotide barcode (10X Genomics). Nuclei from a
GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm
Autor:
Arun Sharma, Lauren K Wasson, Jon AL Willcox, Sarah U Morton, Joshua M Gorham, Daniel M DeLaughter, Meraj Neyazi, Manuel Schmid, Radhika Agarwal, Min Young Jang, Christopher N Toepfer, Tarsha Ward, Yuri Kim, Alexandre C Pereira, Steven R DePalma, Angela Tai, Seongwon Kim, David Conner, Daniel Bernstein, Bruce D Gelb, Wendy K Chung, Elizabeth Goldmuntz, George Porter, Martin Tristani-Firouzi, Deepak Srivastava, Jonathan G Seidman, Christine E Seidman, Pediatric Cardiac Genomics Consortium
Publikováno v:
eLife, Vol 9 (2020)
Damaging GATA6 variants cause cardiac outflow tract defects, sometimes with pancreatic and diaphragmic malformations. To define molecular mechanisms for these diverse developmental defects, we studied transcriptional and epigenetic responses to GATA6
Externí odkaz:
https://doaj.org/article/de48ca73426c4e9e8cd88b2b87f1b9e5
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model
Autor:
Anna Axelsson Raja, Hiroko Wakimoto, Daniel M. DeLaughter, Daniel Reichart, Joshua Gorham, David A. Conner, Mingyue Lun, Clemens K. Probst, Norihiko Sakai, Rachel S. Knipe, Sydney B. Montesi, Barry Shea, Leonard P. Adam, Leslie A. Leinwand, William Wan, Esther Sue Choi, Eric L. Lindberg, Giannino Patone, Michela Noseda, Norbert Hübner, Christine E. Seidman, Andrew M. Tager, J. G. Seidman, Carolyn Y. Ho
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(28)
Myocardial fibrosis is a key pathologic feature of hypertrophic cardiomyopathy (HCM). However, the fibrotic pathways activated by HCM-causing sarcomere protein gene mutations are poorly defined. Because lysophosphatidic acid is a mediator of fibrosis
Autor:
Daniel Reichart, Eric L. Lindberg, Henrike Maatz, Antonio M. A. Miranda, Anissa Viveiros, Nikolay Shvetsov, Anna Gärtner, Emily R. Nadelmann, Michael Lee, Kazumasa Kanemaru, Jorge Ruiz-Orera, Viktoria Strohmenger, Daniel M. DeLaughter, Giannino Patone, Hao Zhang, Andrew Woehler, Christoph Lippert, Yuri Kim, Eleonora Adami, Joshua M. Gorham, Sam N. Barnett, Kemar Brown, Rachel J. Buchan, Rasheda A. Chowdhury, Chrystalla Constantinou, James Cranley, Leanne E. Felkin, Henrik Fox, Ahla Ghauri, Jan Gummert, Masatoshi Kanda, Ruoyan Li, Lukas Mach, Barbara McDonough, Sara Samari, Farnoush Shahriaran, Clarence Yapp, Caroline Stanasiuk, Pantazis I. Theotokis, Fabian J. Theis, Antoon van den Bogaerdt, Hiroko Wakimoto, James S. Ware, Catherine L. Worth, Paul J. R. Barton, Young-Ae Lee, Sarah A. Teichmann, Hendrik Milting, Michela Noseda, Gavin Y. Oudit, Matthias Heinig, Jonathan G. Seidman, Norbert Hubner, Christine E. Seidman
Publikováno v:
Science
Science 377:eabo1984 (2022)
Science 377:eabo1984 (2022)
INTRODUCTION Human heart failure is a highly morbid condition that affects 23 million individuals worldwide. It emerges in the setting of an array of different cardiovascular disorders, which has propelled the notion that diverse stimuli converge on
Autor:
Daniel, Quiat, Seong Won, Kim, Qi, Zhang, Sarah U, Morton, Alexandre C, Pereira, Steven R, DePalma, Jon A L, Willcox, Barbara, McDonough, Daniel M, DeLaughter, Joshua M, Gorham, Justin J, Curran, Melissa, Tumblin, Yamileth, Nicolau, Maria A, Artunduaga, Lourdes, Quintanilla-Dieck, Gabriel, Osorno, Luis, Serrano, Usama, Hamdan, Roland D, Eavey, Christine E, Seidman, J G, Seidman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(21)
Microtia is a congenital malformation that encompasses mild hypoplasia to complete loss of the external ear, or pinna. Although the contribution of genetic variation and environmental factors to microtia remains elusive, Amerindigenous populations ha
Autor:
Daniel M DeLaughter, Cynthia R Clark, Danos C Christodoulou, Christine E Seidman, H Scott Baldwin, J G Seidman, Joey V Barnett
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159710 (2016)
The epicardium plays an important role in coronary vessel formation and Tgfbr3-/- mice exhibit failed coronary vessel development associated with decreased epicardial cell invasion. Immortalized Tgfbr3-/- epicardial cells display the same defects. Tg
Externí odkaz:
https://doaj.org/article/76025aade1e0440483e20299bab1fc46
Autor:
Angela Tai, Elizabeth Goldmuntz, Lauren K. Wasson, Yuri Kim, Manuel Schmid, Deepak Srivastava, Steven R. DePalma, Daniel M. DeLaughter, Jonathan G. Seidman, George A. Porter, Min Young Jang, Arun Sharma, Jon A. L. Willcox, Sarah U. Morton, Alexandre C. Pereira, Radhika Agarwal, Martin Tristani-Firouzi, Seongwon Kim, Joshua M. Gorham, Christine E. Seidman, Tarsha Ward, Christopher N. Toepfer, Meraj Neyazi, Daniel Bernstein, Wendy K. Chung, Bruce D. Gelb, David A. Conner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fabd1d03a5ba415963a8fa292ca44a3
https://doi.org/10.7554/elife.53278.sa2
https://doi.org/10.7554/elife.53278.sa2
GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm
Autor:
Min Young Jang, Yuri Kim, Daniel Bernstein, Deepak Srivastava, Jonathan G. Seidman, Elizabeth Goldmuntz, Daniel M. DeLaughter, Manuel Schmid, Christopher N. Toepfer, David A. Conner, Angela Tai, Steven R. DePalma, Alexandre C. Pereira, Bruce D. Gelb, Jon A. L. Willcox, Meraj Neyazi, George A. Porter, Arun Sharma, Radhika Agarwal, Martin Tristani-Firouzi, Tarsha Ward, Lauren K. Wasson, Sarah U. Morton, Seongwon Kim, Joshua M. Gorham, Christine E. Seidman, Wendy K. Chung
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Damaging GATA6 variants cause cardiac outflow tract defects, sometimes with pancreatic and diaphragmic malformations. To define molecular mechanisms for these diverse developmental defects, we studied transcriptional and epigenetic responses to GATA6
Autor:
Joshua M. Gorham, Christine E. Seidman, Krishnaa T. Mahbubani, Jon G. Seidman, Krzysztof Polanski, Eric L. Lindberg, Daniel M. DeLaughter, Kenny Roberts, Hongbo Zhang, Eirini S. Fasouli, Emily R. Nadelmann, Catherine L. Worth, Michela Noseda, Daniel Reichart, Norbert Hubner, Hiroko Wakimoto, Barbara McDonough, Matthias Heinig, Giannino Patone, Gavin Y. Oudit, Liz Tuck, Sarah A. Teichmann, Omer Ali Bayraktar, Carlos Talavera-López, Monika Litviňuková, Anissa Viveiros, Kourosh Saeb-Parsy, Hao Zhang, Henrike Maatz, Sara Samari, Masatoshi Kanda, Joseph J. Boyle
SummaryCardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and strategies to improve therapeutic opportunities require deeper understanding of the molecular processes of the normal heart. Knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f287357f8226b2f47cb2fa3f3a6c0019
http://edoc.mdc-berlin.de/18937/1/18937oa.pdf
http://edoc.mdc-berlin.de/18937/1/18937oa.pdf