Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Daniel M. Davis"'
Autor:
Jonathan D. Worboys, Katherine N. Vowell, Roseanna K. Hare, Ashley R. Ambrose, Margherita Bertuzzi, Michael A. Conner, Florence P. Patel, William H. Zammit, Judit Gali-Moya, Khodor S. Hazime, Katherine L. Jones, Camille Rey, Stipan Jonjic, Tihana Lenac Rovis, Gillian M. Tannahill, Gabriela Dos Santos Cruz De Matos, Jeremy D. Waight, Daniel M. Davis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through competition of shared ligands. Whether TIGIT directly delivers cell-intrinsic inhibito
Externí odkaz:
https://doaj.org/article/748927d78b7a4a85add810c7f0791c02
Autor:
Claire O’Leary, Gabriella Forte, Nadia L. Mitchell, Amir Saam Youshani, Adam Dyer, Martin P. Wellby, Katharina N. Russell, Samantha J. Murray, Nelly Jolinon, Simon A Jones, Kevin Stacey, Daniel M. Davis, Els Henckaerts, David N. Palmer, Ian Kamaly-Asl, Brian W. Bigger
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Mucopolysaccharidosis IIIC (MPSIIIC) is one of four Sanfilippo diseases sharing clinical symptoms of severe cognitive decline and shortened lifespan. The missing enzyme, heparan sulfate acetyl-CoA: α-glucosaminide-N-acetyltransfe
Externí odkaz:
https://doaj.org/article/193bffc76643439f9aca34c4f8d77145
Autor:
Alireza Bahadori, William E. Holt, Jacqueline Austermann, Lajhon Campbell, E. Troy Rasbury, Daniel M. Davis, Christopher M. Calvelage, Lucy M. Flesch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
A long-standing controversy surrounds low-angle nature of observed detachment faults within metamorphic core complexes. Here, the authors show that post-orogenic collapse of mountain belts can create a low-angle detachment, resolving the controversy.
Externí odkaz:
https://doaj.org/article/8c37eb86a72545199ab691a99086601f
Autor:
Alireza Bahadori, William E. Holt, Ran Feng, Jacqueline Austermann, Katharine M. Loughney, Tristan Salles, Louis Moresi, Romain Beucher, Neng Lu, Lucy M. Flesch, Christopher M. Calvelage, E. Troy Rasbury, Daniel M. Davis, Andre R. Potochnik, W. Bruce Ward, Kevin Hatton, Saad S. B. Haq, Tara M. Smiley, Kathleen M. Wooton, Catherine Badgley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cenozoic landscape evolution of southwestern North America remains debated. Here, the authors reconstruct landscape using 4-D numerical models, which can explain extensional collapse and superficial geological record for the Basin and Range Province
Externí odkaz:
https://doaj.org/article/baeab67961c341568da4ee0937f71067
Autor:
Susanne Dechantsreiter, Ashley R. Ambrose, Jonathan D. Worboys, Joey M. E. Lim, Sylvia Liu, Rajesh Shah, M. Angeles Montero, Anne Marie Quinn, Tracy Hussell, Gillian M. Tannahill, Daniel M. Davis
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 4, Pp n/a-n/a (2022)
Abstract The diverse origins, nanometre‐scale and invasive isolation procedures associated with extracellular vesicles (EVs) mean they are usually studied in bulk and disconnected from their parental cell. Here, we used super‐resolution microscop
Externí odkaz:
https://doaj.org/article/b757983969c0432a9dc11231c7a45208
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cytotoxic lymphocytes are critical in our immune defence against cancer and infection. Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells in at least two ways: granule-mediated cytotoxicity, involving perfo
Externí odkaz:
https://doaj.org/article/d7f4f0a268f1411fa71587a4b0516319
Autor:
David J. Williamson, Garth L. Burn, Sabrina Simoncelli, Juliette Griffié, Ruby Peters, Daniel M. Davis, Dylan M. Owen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The characterization of clusters in single-molecule microscopy data is vital to reconstruct emerging spatial patterns. Here, the authors present a fast and accurate machine-learning approach to clustering, to address the issues related to the size of
Externí odkaz:
https://doaj.org/article/5bc574d8c2a043d098ecae44cf7959d5
Autor:
Elaine Y.L. Leung, Darren P. Ennis, Philippa R. Kennedy, Christopher Hansell, Suzanne Dowson, Malcolm Farquharson, Pavlina Spiliopoulou, Jaya Nautiyal, Sophie McNamara, Leo M. Carlin, Kerry Fisher, Daniel M. Davis, Gerard Graham, Iain A. McNeish
Publikováno v:
Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 289-301 (2020)
Oncolytic viruses (OVs) can trigger profound innate and adaptive immune responses, which have the potential both to potentiate and reduce the activity of OVs. Natural killer (NK) cells can mediate potent anti-viral and anti-tumoral responses, but the
Externí odkaz:
https://doaj.org/article/29c364221e2742ba880eac2a34ef2941
Autor:
Anna Gritsenko, Shi Yu, Fatima Martin-Sanchez, Ines Diaz-del-Olmo, Eva-Maria Nichols, Daniel M. Davis, David Brough, Gloria Lopez-Castejon
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/81cfd4f2726141ab98b471be2022bfc6
Autor:
Ines Diaz-del-Olmo, Jonathan Worboys, Fatima Martin-Sanchez, Anna Gritsenko, Ashley R. Ambrose, Gillian M. Tannahill, Eva-Maria Nichols, Gloria Lopez-Castejon, Daniel M. Davis
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as macrophages, upon recognition of danger signals. Its secretion is regulated by the inflammasome, the assembly of which results in caspase 1 activatio
Externí odkaz:
https://doaj.org/article/3725774fdbf7494f95b7d579404763b0