Zobrazeno 1 - 10
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pro vyhledávání: '"Daniel M Weinreich"'
Autor:
Daniel M Weinreich
Publikováno v:
eLife, Vol 11 (2022)
Analyzing how mutations affect the main protease of SARS-CoV-2 may help researchers develop drugs that are effective against current and future variants of the virus.
Externí odkaz:
https://doaj.org/article/38f6fc4854d441ed8d4b49361e04271b
Autor:
Gabriel Monteiro da Silva, Jordan Yang, Bunlong Leang, Jessie Huang, Daniel M Weinreich, Brenda M Rubenstein
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1009944 (2022)
The rate of modern drug discovery using experimental screening methods still lags behind the rate at which pathogens mutate, underscoring the need for fast and accurate predictive simulations of protein evolution. Multidrug-resistant bacteria evade o
Externí odkaz:
https://doaj.org/article/f9d6e34b4a8c49e8ae7c315834a59809
Autor:
Jordan Yang, Nandita Naik, Jagdish Suresh Patel, Christopher S Wylie, Wenze Gu, Jessie Huang, F Marty Ytreberg, Mandar T Naik, Daniel M Weinreich, Brenda M Rubenstein
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233509 (2020)
One of the long-standing holy grails of molecular evolution has been the ability to predict an organism's fitness directly from its genotype. With such predictive abilities in hand, researchers would be able to more accurately forecast how organisms
Externí odkaz:
https://doaj.org/article/dec4a6ec61a94cbda837159c5ce72f0b
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004710 (2016)
The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to applications of these concepts i
Externí odkaz:
https://doaj.org/article/4cc2e798174b4caaac5c1c34919752e6
Autor:
Yevgeniy Raynes, Daniel M. Weinreich
Ploidy – the number of homologous chromosome sets in a cell – is remarkably variable across the natural world, yet the evolutionary processes that have resulted in such diversity remain poorly understood. Here we use stochastic agent-based simula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f3c9e71124596928fb352725eeb5acc
https://doi.org/10.1101/2021.10.26.465943
https://doi.org/10.1101/2021.10.26.465943
Autor:
Daniel M. Weinreich, A. G. McDonald, Andreas E. Vasdekis, Abhyudai Singh, Dhuey Sd, Shahla Nemati
Single-cells grow by increasing their biomass and size. Here, we report that while mass and size accumulation rates of single Escherichia coli cells are exponential, their density fluctuates during growth. As such, the rates of mass and size accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f091d70d0d1b35aeaf65a3e52c3b5bf9
https://doi.org/10.1101/2021.05.14.444254
https://doi.org/10.1101/2021.05.14.444254
Autor:
Shahla Nemati, Abhyudai Singh, Scott D. Dhuey, Armando McDonald, Daniel M. Weinreich, Andreas. E. Vasdekis
Publikováno v:
Communications biology, vol 5, iss 1
Single-cells grow by increasing their biomass and size. Here, we report that while mass and size accumulation rates of single Escherichia coli cells are exponential, their density and, thus, the levels of macromolecular crowding fluctuate during grow
Autor:
Daniel M. Weinreich
Publikováno v:
Nature Physics. 17:17-19
Populations of organisms can be regarded as clouds of genetic variants evolving passively in response to mutation and natural selection. Counterdiabatic driving — a tool borrowed from quantum control — now offers the possibility of actively contr
Autor:
Yevgeniy Raynes, Daniel M. Weinreich
Publikováno v:
Evolutionary Applications, Vol 12, Iss 2, Pp 301-313 (2019)
Evolutionary Applications
Evolutionary Applications
Most solid cancers are characterized by chromosomal instability (CIN)—an elevated rate of large‐scale chromosomal aberrations and ploidy changes. Chromosomal instability may arise through mutations in a range of genomic integrity loci and is comm
Classical evolutionary theory holds that the efficiency, but not the direction, of natural selection depends on population size. In small populations, drift overwhelms selection, rendering all fitness-affecting mutations selectively neutral. Yet, ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c53d53d68939492837f061f9a9fc35
https://doi.org/10.1101/2021.04.19.440541
https://doi.org/10.1101/2021.04.19.440541