Výsledky vyhledávání - "Daniel M Murante"

Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases

Autor: Jan Abendroth, Katy M Alden, Jameson Bullen, Taiwo E Esan, Timothy J. Hagen, Damian J. Krysan, Nicholas D DeBouver, Daniel M Murante, Andrew J. Jezewski, Brandy Calhoun, David A. Fox, Kristy T Potts

Publikováno v: ACS Chemical Biology

Acetyl CoA synthetases (ACSs) are Acyl-CoA/NRPS/Luciferase (ANL) superfamily enzymes that couple acetate with CoA to generate acetyl CoA, a key component of central carbon metabolism in eukaryotes and prokaryotes. Normal mammalian cells are not depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b112a328679570b35d241bb455583c3
https://pubmed.ncbi.nlm.nih.gov/34369755

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Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis

Autor: Bao Vu, Daniel M Murante, W. Scott Moye-Rowley, Josie E. Parker, Steven L. Kelly, Tomye L. Ollinger, Laura Doorley, P. David Rogers, Mark Stamnes, Lucia Simonicova, Damian J. Krysan

Publikováno v: mSphere, Vol 6, Iss 6 (2021)
mSphere

Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18d255f5b8121fdc12c03cd2c28b808
https://cronfa.swan.ac.uk/Record/cronfa59202

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