Evidence for immune activation in pathogenesis of the HLA class II associated disease, podoconiosis

Autor: Mikias Negash, Menberework Chanyalew, Tigist Girma, Fekadu Alemu, Diana Alcantara, Ben Towler, Gail Davey, Rosemary J. Boyton, Daniel M. Altmann, Rawleigh Howe, Melanie J. Newport

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Available evidences suggest that podoconiosis is triggered by long term exposure of bare feet to volcanic red clay soil particles. Previous genome-wide studies in Ethiopia showed association between the HLA class II region and disease suscep

Externí odkaz: https://doaj.org/article/c6f3362044564d42a0118f0622a53437

Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network)

Autor: Giselle da Silva Duarte, Alexandra D. Jones, Luciano Pamplona de Goes Cavalcanti, Moacyr Jesus Barreto de Melo Rêgo, Guilherme S. Ribeiro, Rosemary J. Boyton, Dhelio Batista Pereira, Julio Henrique Rosa Croda, Fabio Trindade Maranhão Costa, Angela Pinto Duarte, Marcia Edilaine Lopes Consolaro, Rodrigo Guerino Stabeli, Fábio Juliano Negrão, Jose Luiz Proenca-Modena, Juan Miguel Villalobos-Salcedo, Geraldo da Rocha Castelar Pinheiro, Amanda Pinheiro de Barros Albuquerque, Francisca Kalline de Almeida Barreto, Jose Moreira, Idalina Cristina Ferrari, Patricia Martinez Évora, Vânia Ramos Sela da Silva, Marcus Vinicius Guimarães Lacerda, Daniel M. Altmann, REPLICK network, André M. Siqueira

Publikováno v: BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-12 (2023)

Abstract Background Chikungunya is associated with high morbidity and the natural history of symptomatic infection has been divided into three phases (acute, post-acute, and chronic) according to the duration of musculoskeletal symptoms. Although thi

Externí odkaz: https://doaj.org/article/971e70649fb24de9818278544cb93d16

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection

Autor: Martina Milighetti, Yanchun Peng, Cedric Tan, Michal Mark, Gayathri Nageswaran, Suzanne Byrne, Tahel Ronel, Tom Peacock, Andreas Mayer, Aneesh Chandran, Joshua Rosenheim, Matthew Whelan, Xuan Yao, Guihai Liu, Suet Ling Felce, Tao Dong, Alexander J. Mentzer, Julian C. Knight, Francois Balloux, Erez Greenstein, Shlomit Reich-Zeliger, Corinna Pade, Joseph M. Gibbons, Amanda Semper, Tim Brooks, Ashley Otter, Daniel M. Altmann, Rosemary J. Boyton, Mala K. Maini, Aine McKnight, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Mahdad Noursadeghi, Benny Chain

Publikováno v: iScience, Vol 26, Iss 6, Pp 106937- (2023)

Summary: T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of indiv

Externí odkaz: https://doaj.org/article/a3d7eacf94e249aeb9cbbd5c5378f753

Hybrid Immunity Results in Enhanced and More Sustained Antibody Responses after the Second Sinovac-CoronaVac Dose in a Brazilian Cohort: DETECTCoV-19 Cohort

Autor: Bárbara Batista Salgado, Aguyda Rayany Cavalcante Barbosa, Ana Ruth Arcanjo, Daniel Barros de Castro, Tatyana Costa Amorim Ramos, Felipe Naveca, Daniel M. Altmann, Rosemary J. Boyton, Jaila Dias Borges Lalwani, Pritesh Lalwani

Publikováno v: Viruses, Vol 15, Iss 10, p 1987 (2023)

We measured anti-SARS-CoV-2 antibody responses before and after CoronaVac (inactivated) vaccination in a case–control study performed in CoronaVac-immunized individuals participating in a longitudinal prospective study of adults in Manaus (DETECTCo

Externí odkaz: https://doaj.org/article/13e412c611924cf2b543011b3e976169

Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response

Autor: Ivan Doykov, Tomas Baldwin, Justyna Spiewak, Kimberly C. Gilmour, Joseph M. Gibbons, Corinna Pade, Catherine J. Reynolds, Áine McKnight, Mahdad Noursadeghi, Mala K. Maini, Charlotte Manisty, Thomas Treibel, Gabriella Captur, Marianna Fontana, Rosemary J. Boyton, Daniel M. Altmann, Tim Brooks, Amanda Semper, James C. Moon, Kevin Mills, Wendy E. Heywood, Hakam Abbass, Aderonke Abiodun, Mashael Alfarih, Zoe Alldis, Oliver E. Amin, Mervyn Andiapen, Jessica Artico, João B. Augusto, Georgina L. Baca, Sasha N.L. Bailey, Anish N. Bhuva, Alex Boulter, Ruth Bowles, Olivia V. Bracken, Ben O’Brien, Natalie Bullock, David K. Butler, Olivia Carr, Nicola Champion, Carmen Chan, Aneesh Chandran, Tom Coleman, Jorge Couto de Sousa, Xose Couto-Parada, Eleanor Cross, Teresa Cutino-Moguel, Silvia D’Arcangelo, Rhodri H. Davies, Brooke Douglas, Cecilia Di Genova, Keenan Dieobi-Anene, Mariana O. Diniz, Anaya Ellis, Karen Feehan, Malcolm Finlay, Nasim Forooghi, Sasha Francis, David Gillespie, Derek Gilroy, Matt Hamblin, Gabrielle Harker, Georgia Hemingway, Jacqueline Hewson, Wendy Heywood, Lauren M. Hickling, Bethany Hicks, Aroon D. Hingorani, Lee Howes, Ivie Itua, Victor Jardim, Wing-Yiu Jason Lee, Melaniepetra Jensen, Jessica Jones, Meleri Jones, George Joy, Vikas Kapil, Caoimhe Kelly, Hibba Kurdi, Jonathan Lambourne, Kai-Min Lin, Siyi Liu, Aaron Lloyd, Sarah Louth, Vineela Mandadapu, Katia Menacho, Celina Mfuko, Sebastian Millward, Oliver Mitchelmore, Christopher Moon, James Moon, Diana Muñoz Sandoval, Sam M. Murray, Ashley Otter, Susana Palma, Ruth Parker, Kush Patel, Mihaela Pawarova, Steffen E. Petersen, Brian Piniera, Franziska P. Pieper, Lisa Rannigan, Alicja Rapala, Amy Richards, Matthew Robathan, Joshua Rosenheim, Cathy Rowe, Matthew Royds, Jane Sackville West, Genine Sambile, Nathalie M. Schmidt, Hannah Selman, Andreas Seraphim, Mihaela Simion, Angelique Smit, Michelle Sugimoto, Leo Swadling, Stephen Taylor, Nigel Temperton, Stephen Thomas, George D. Thornton, Thomas A. Treibel, Art Tucker, Ann Varghese, Jessry Veerapen, Mohit Vijayakumar, Tim Warner, Sophie Welch, Hannah White, Theresa Wodehouse, Lucinda Wynne, Dan Zahedi

Publikováno v: Cell Reports: Methods, Vol 2, Iss 9, Pp 100279- (2022)

Summary: Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immune

Externí odkaz: https://doaj.org/article/9be530f264774b93a8869c019914391d