Cre-Dependent Optogenetic Transgenic Mice Without Early Age-Related Hearing Loss

Autor: Daniel Lyngholm, Shuzo Sakata

Publikováno v: Frontiers in Aging Neuroscience, Vol 11 (2019)

With the advent of recent genetic technologies for mice, it is now feasible to investigate the circuit mechanisms of brain functions in an unprecedented manner. Although transgenic mice are commonly used on C57BL/6J (C57) background, hearing research

Externí odkaz: https://doaj.org/article/ba246c5213034f60a1db1a9e54bfc02a

Standard anatomical and visual space for the mouse retina: computational reconstruction and transformation of flattened retinae with the Retistruct package.

Autor: David C Sterratt, Daniel Lyngholm, David J Willshaw, Ian D Thompson

Publikováno v: PLoS Computational Biology, Vol 9, Iss 2, p e1002921 (2013)

The concept of topographic mapping is central to the understanding of the visual system at many levels, from the developmental to the computational. It is important to be able to relate different coordinate systems, e.g. maps of the visual field and

Externí odkaz: https://doaj.org/article/b373b0ae3fd9404bbfcea7c30a00fde3

Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex

Autor: Anna Hoerder-Suabedissen, Yasushi Nakagawa, Andre Marques-Smith, Filippo Ghezzi, Zoltán Molnár, Alexandra Rowett, Simon J. B. Butt, Daniel Lyngholm, Gokul Parameswaran, Paul G. Anastasiades, Cristiana Vagnoni

Publikováno v: eLife, Vol 10 (2021)
Ghezzi, F, Marques-Smith, A, Anastasiades, P G, Lyngholm, D, Vagnoni, C, Rowett, A, Parameswaran, G, Hoerder-Suabedissen, A, Nakagawa, Y, Molnar, Z & Butt, S J B 2021, ' Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex ', eLife, vol. 10, e60810 . https://doi.org/10.7554/eLife.60810
eLife

Subplate neurons (SPNs) are thought to play a role in nascent sensory processing in neocortex. To better understand how heterogeneity within this population relates to emergent function, we investigated the synaptic connectivity of Lpar1-EGFP SPNs th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9154a5386b8c29ca242c6975d50eab5
https://elifesciences.org/articles/60810

Measuring and Modelling the Emergence of Order in the Mouse Retinocollicular Projection

Autor: Hjorth Jjj, Daniel Lyngholm, Ian D. Thompson, David Willshaw, David C. Sterratt, Stephen J. Eglen

In the formation of retinotopic maps both experimental and theoretical work implicate guidance molecules and patterned neuronal activity. A common view is that molecular cues define and activity cues refine mappings. Important insights have come from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb16d2961d99ae54a0ac00e758d39efe
https://doi.org/10.1101/713628

GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex

Autor: Sayda Raffiq, Simon J. B. Butt, Dennis Kätzel, Andre Marques-Smith, Tom Lickiss, Daniel Lyngholm, Gero Miesenböck, Paul G. Anastasiades

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications

GABAergic interneurons play key roles in cortical circuits, yet little is known about their early connectivity. Here we use glutamate uncaging and a novel optogenetic strategy to track changes in the afferent and efferent synaptic connections of deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ab0fb7be58ab265a9d5bcb50146c44
https://doaj.org/article/eecafeca6fe24e208afc545e3bdbe8ed