Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Daniel Lucena‐Agell"'
Autor:
Noelia Hernández-Ortiz, Pedro A. Sánchez-Murcia, Celia Gil-Campillo, Mirian Domenech, Daniel Lucena-Agell, Rafael Hortigüela, Sonsoles Velázquez, María José Camarasa, Noemí Bustamante, Sonia de Castro, Margarita Menéndez
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cationic ultrashort lipopeptides (USLPs) are promising antimicrobial candidates to combat multidrug-resistant bacteria. Using DICAMs, a newly synthesized family of tripeptides with net charges from −2 to +1 and a fatty amine conjugated to the C-ter
Externí odkaz:
https://doaj.org/article/a70e508a6e444b3684cb75e82eb032ee
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Publikováno v:
eLife, Vol 12 (2023)
Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a tubulin-taxane complex precludes
Externí odkaz:
https://doaj.org/article/ae0411d1a2f8477a839b678a56356407
Autor:
Harrisson D. A. Santos, Irene Zabala Gutiérrez, Yingli Shen, José Lifante, Erving Ximendes, Marco Laurenti, Diego Méndez-González, Sonia Melle, Oscar G. Calderón, Enrique López Cabarcos, Nuria Fernández, Irene Chaves-Coira, Daniel Lucena-Agell, Luis Monge, Mark D. Mackenzie, José Marqués-Hueso, Callum M. S. Jones, Carlos Jacinto, Blanca del Rosal, Ajoy K. Kar, Jorge Rubio-Retama, Daniel Jaque
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Deep tissue imaging has been limited by the low brightness of probes emitting in the second near-infrared window. Here, the authors use femtosecond laser irradiation to grow a protective shell on Ag2S nanoparticles, achieving 80-fold quantum yield en
Externí odkaz:
https://doaj.org/article/8f21713af2154304b4495a616e52e028
Autor:
Bryce Keenan, Rocio K. Finol-Urdaneta, Ashleigh Hope, John B. Bremner, Maria Kavallaris, Daniel Lucena-Agell, María Ángela Oliva, Jose Fernando Díaz, Kara L. Vine
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-16 (2020)
Abstract Background Drug resistance and chemotherapy-induced peripheral neuropathy continue to be significant problems in the successful treatment of acute lymphoblastic leukemia (ALL). 5,7-Dibromo-N-alkylisatins, a class of potent microtubule destab
Externí odkaz:
https://doaj.org/article/34fe436bd9534a28afde02519c3f76ea
Autor:
Nathália Moreno Cury, Tobias Mühlethaler, Angelo Brunelli Albertoni Laranjeira, Rafael Renatino Canevarolo, Priscila Pini Zenatti, Daniel Lucena-Agell, Isabel Barasoain, Chunhua Song, Dongxiao Sun, Sinisa Dovat, Rosendo Augusto Yunes, Andrea Enrico Prota, Michel Olivier Steinmetz, José Fernando Díaz, José Andrés Yunes
Publikováno v:
iScience, Vol 21, Iss , Pp 95-109 (2019)
Summary: Tubulin is one of the best validated anti-cancer targets, but most anti-tubulin agents have unfavorable therapeutic indexes. Here, we characterized the tubulin-binding activity, the mechanism of action, and the in vivo anti-leukemia efficacy
Externí odkaz:
https://doaj.org/article/67ad75df1ed143b6b2d81f30461805ab
Autor:
María Ángela Oliva, Carlota Tosat-Bitrián, Lucía Barrado-Gil, Francesca Bonato, Inmaculada Galindo, Urtzi Garaigorta, Beatriz Álvarez-Bernad, Rebeca París-Ogáyar, Daniel Lucena-Agell, Juan Francisco Giménez-Abián, Isabel García-Dorival, Jesús Urquiza, Pablo Gastaminza, José Fernando Díaz, Valle Palomo, Covadonga Alonso
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3448 (2022)
Microtubule targeting agents (MTAs) have been exploited mainly as anti-cancer drugs because of their impact on cellular division and angiogenesis. Additionally, microtubules (MTs) are key structures for intracellular transport, which is frequently hi
Externí odkaz:
https://doaj.org/article/2671d7e2726042098829308ac7b619d1
Autor:
Juan Estévez-Gallego, Fernando Josa-Prado, Siou Ku, Ruben M Buey, Francisco A Balaguer, Andrea E Prota, Daniel Lucena-Agell, Christina Kamma-Lorger, Toshiki Yagi, Hiroyuki Iwamoto, Laurence Duchesne, Isabel Barasoain, Michel O Steinmetz, Denis Chrétien, Shinji Kamimura, J Fernando Díaz, Maria A Oliva
Publikováno v:
eLife, Vol 9 (2020)
Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs, GTP hydrolysis triggers structural changes in the lattice, which
Externí odkaz:
https://doaj.org/article/eb49d1e2fe6445b783e2a3c85b0c7bbb
Autor:
Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J. Fernando Díaz, Karl-Heinz Altmann, Michel O. Steinmetz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identi
Externí odkaz:
https://doaj.org/article/0ff5964567e04f11ab1504ca1c9d29cf
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6031650b263dc281c6bcce2894cf2134
https://doi.org/10.7554/elife.84791.sa2
https://doi.org/10.7554/elife.84791.sa2
Autor:
Zlata Boiarska, Helena Pérez‐Peña, Anne‐Catherine Abel, Paola Marzullo, Beatriz Álvarez‐Bernad, Francesca Bonato, Benedetta Santini, Dragos Horvath, Daniel Lucena‐Agell, Francesca Vasile, Maurizio Sironi, J. Fernando Díaz, Andrea E. Prota, Stefano Pieraccini, Daniele Passarella
Publikováno v:
Chemistry – A European Journal. 29
11 p.-7 fig.-4 tab. 7 schem.
Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has be
Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has be