Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

Autor: Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi

Publikováno v: Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)

Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more c

Externí odkaz: https://doaj.org/article/0c66d90901d244e6922dd1f9ea0a3f1f

A versatile workflow to integrate RNA-seq genomic and transcriptomic data into mechanistic models of signaling pathways.

Autor: Martín Garrido-Rodriguez, Daniel Lopez-Lopez, Francisco M Ortuno, María Peña-Chilet, Eduardo Muñoz, Marco A Calzado, Joaquin Dopazo

Publikováno v: PLoS Computational Biology, Vol 17, Iss 2, p e1008748 (2021)

MIGNON is a workflow for the analysis of RNA-Seq experiments, which not only efficiently manages the estimation of gene expression levels from raw sequencing reads, but also calls genomic variants present in the transcripts analyzed. Moreover, this i

Externí odkaz: https://doaj.org/article/65ddef7a579444e2b145e6b95460fc76

Supplementary Table S4 from Predictive Value of MRP-1 in Localized High-Risk Soft Tissue Sarcomas: A Translational Research Associated to ISG-STS 1001 Randomized Phase III Trial

Autor: Alessandro Gronchi, Paolo G. Casali, Piero Picci, Angelo Paolo Dei Tos, Nadia Hindi, Claudia Valverde, Antonio Gutierrez, Antonella Brunello, Jean-Yves Blay, Giovanni Grignani, Antonio Lopez-Pousa, Vittorio L. Quagliuolo, Silvia Stacchiotti, Emanuela Palmerini, Domenico Franco Merlo, Luca Braglia, Marco Gambarotti, Joaquin Dopazo, Daniel Lopez-Lopez, Jean-Michel Coindre, Valerie Velasco, Marta Barisella, Salvatore L. Renne, Silvia Bagué, Cleofe Romagosa, Paola Collini, Rafael Ramos, David S. Moura, Maria Lopez-Alvarez, Javier Martin-Broto

Supplementary Table S4 - Affinity energies of nilotinib and avapritinib for the different structures of MRP-1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcabbb9fa5e7a9c881a50f56a200c06
https://doi.org/10.1158/1535-7163.22522890

Burnout, resilience and psychological flexibility in frontline nurses during the acute phase of the COVID-19 pandemic (2020) in Madrid, Spain

Autor: Raquel Jiménez‐Fernández, Inmaculada Corral‐Liria, Bibiana Trevissón‐Redondo, Daniel Lopez‐Lopez, Marta Losa‐Iglesias, Ricardo Becerro‐de‐Bengoa‐Vallejo

Publikováno v: Journal of nursing managementREFERENCES. 30(7)

In April 2020, Spain was the country with the highest number of patients infected by COVID-19 in Europe. The pressure on health care providers has had a direct impact on nurses and their mental health.The aim of this study is to demonstrate the causa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cc1540660d67c43b808f7b7bc84a7c
https://pubmed.ncbi.nlm.nih.gov/36042534

Predictive Value of MRP-1 in Localized High-Risk Soft Tissue Sarcomas: A Translational Research Associated to ISG-STS 1001 Randomized Phase III Trialmm

Autor: Jean-Yves Blay, Domenico Franco Merlo, Claudia Valverde, Antonella Brunello, Paola Collini, Salvatore Lorenzo Renne, Cleofé Romagosa, Antonio Lopez-Pousa, Joaquín Dopazo, Silvia Stacchiotti, Piero Picci, Angelo Paolo Dei Tos, Marco Gambarotti, Marta Barisella, Rafael Ramos, Paolo G. Casali, Antonio Gutierrez, Valérie Velasco, J. Martin-Broto, Silvia Bagué, David S. Moura, Nadia Hindi, Vittorio Quagliuolo, Giovanni Grignani, Maria Lopez-Alvarez, Alessandro Gronchi, Jean-Michel Coindre, Daniel Lopez-Lopez, Emanuela Palmerini, Luca Braglia

Publikováno v: MOLECULAR CANCER THERAPEUTICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Digital.CSIC. Repositorio Institucional del CSIC

MRP-1 is implicated in multidrug resistance and was described as prognostic in high-risk patients with soft-tissue sarcoma (STS) in a previous study. The current research aimed to validate MRP-1 prognostic/predictive value in localized sarcomas treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90367e16a0d25d3d6c9799f59d60ae8
http://hdl.handle.net/10261/269712