Výsledky vyhledávání - "Daniel Logsdon"

Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice

Autor: Konstantin Salnikow, Bhalchandra A. Diwan, Monika Kaczmarek, Kazimierz S. Kasprzak, Mathew J. Fivash, Daniel Logsdon

Publikováno v: Toxicology and Applied Pharmacology. 257:32-37

The aim of this study was to test a hypothesis that ascorbate depletion could enhance carcinogenicity and acute toxicity of nickel. Homozygous L-gulono--lactone oxidase gene knock-out mice (Gulo-/- mice) unable to produce ascorbate and wild-type C57B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2532b5fec6a79e9d861272cb4fe59d
https://doi.org/10.1016/j.taap.2011.08.015

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GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier

Autor: Diana C. Haines, Janine Stevens, Kunio Nagashima, Xiujie Li, Mike Cullen, Mi Young Yang, Frank Cuttitta, Amit Chaudhary, Lihong Xu, Lino Tessarollo, Daniel Logsdon, Mary Beth Hilton, Emily Hsiao, Erica V. Stein, Steven Seaman, Mohammed K. Elzarrad, Enrique Zudaire, Brad St. Croix

Publikováno v: Proceedings of the National Academy of Sciences. 108:5759-5764

Every organ in the body requires blood vessels for efficient delivery of oxygen and nutrients, but independent vascular beds are highly specialized to meet the individual needs of specific organs. The vasculature of the brain is tightly sealed, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c0c81e43ffb09cc2b6a1804e0684ef
https://doi.org/10.1073/pnas.1017192108

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Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma

Autor: Diana C. Haines, Steven Seaman, Amit Chaudhary, Mary Beth Hilton, Lino Tessarollo, Mi Young Yang, Brad St. Croix, Daniel Logsdon, Mike Cullen

Publikováno v: Cancer Research. 69:6021-6026

Tumor endothelial marker 8 (TEM8) wasinitially identified asageneoverexpressedinthevasculatureofhumantumorsandwas subsequently identified as an anthrax toxin receptor.To assess the functional role of TEM8, we disrupted theTEM8 gene in mice by targete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a62e1b3d609a4984e12ec18aed8d1675
https://doi.org/10.1158/0008-5472.can-09-1086

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Marked Liver Tumorigenesis by Helicobacter hepaticus Requires Perinatal Exposure

Autor: Miriam R. Anver, M A Sipowicz, Bhalchandra A. Diwan, Lucy M. Anderson, Kazimierz S. Kasprzak, Daniel Logsdon, Peter L. Gorelick

Publikováno v: Environmental Health Perspectives

Background Although severe hepatitis and liver tumors occur in a high percentage of A/J male mice naturally infected with Helicobacter hepaticus, these effects have not been observed after injection of adult mice with the bacteria. Objectives We test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66eaaa856348b2c5ea98f8820db150af
https://doi.org/10.1289/ehp.11493

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Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic

Autor: Yaxiong Xie, Daniel Logsdon, Jie Liu, Bhalchandra A. Diwan, Michael P. Waalkes, Jerry M. Ward, Lamia Benbrahim-Tallaa

Publikováno v: Toxicology. 236:7-15

Our prior work showed that brief exposure of pregnant C3H mice to inorganic arsenic-induced hepatocellular carcinoma (HCC) formation in adult male offspring. The current study examined the early hepatic events associated with this oncogenic transform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7605c89fe11e3e939ace7a1e6f3d9e0e
https://doi.org/10.1016/j.tox.2007.03.021

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Genes that Distinguish Physiological and Pathological Angiogenesis

Autor: Brad St. Croix, Cari Graff-Cherry, Mi Young Yang, Daniel Logsdon, Steven Seaman, Janine Stevens

Publikováno v: Cancer Cell. 11:539-554

SummaryTo unravel the normal vasculature transcriptome and determine how it is altered by neighboring malignant cells, we compared gene expression patterns of endothelial cells derived from the blood vessels of eight normal resting tissues, five tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b406bc032933a3717846b894061bd41
https://doi.org/10.1016/j.ccr.2007.04.017

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Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver

Autor: Jennifer B. Collins, Bhalchandra A. Diwan, Daniel Logsdon, Michael P. Waalkes, B. Alex Merrick, Yaxiong Xie, Danica M.K. Ducharme, Jie Liu, Jun Shen

Publikováno v: Toxicology and Applied Pharmacology. 213:216-223

Our prior work shows that in utero arsenic exposure alone is a complete transplacental carcinogen, producing hepatocellular carcinoma in adult male offspring but not in females. In a follow-up study to potentially promote arsenic-initiated tumors, mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c664e1e8e13fa813369c0b9ae902f9f
https://doi.org/10.1016/j.taap.2005.10.010

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COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models

Autor: Janine Stevens, Enrique Zudaire, Mary Beth Hilton, Daniel Logsdon, Lihong Xu, Holly Morris, Deborah A. Swing, Timothy D. Veenstra, Steven Seaman, Nimit L. Patel, Joseph D. Kalen, Brad St. Croix, Thomas P. Conrads, Diana C. Haines

Publikováno v: Oncotarget

Anti-angiogenic agents that block Vascular Endothelial Growth Factor (VEGF) signaling are important components of current cancer treatment modalities but are limited by alternative ill-defined angiogenesis mechanisms that allow persistent tumor vascu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d75a05b986f1772f8597c10d13bd3de
https://europepmc.org/articles/PMC6309995/

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Skin tumorigenesis and Ki-ras and Ha-ras mutations in tumors from adult mice exposed in utero to 3′-azido-2′,3′-dideoxythymidine

Autor: Jerry M. Rice, Stuart H. Yuspa, Ofelia A. Olivero, Daniel Logsdon, Zhihua Zhang, Bhalchandra A. Diwan, Miriam C. Poirier, Diana C. Haines, Lucy M. Anderson

Publikováno v: Molecular Carcinogenesis. 23:45-51

This study was designed to evaluate the potential initiating effects of transplacental 3′-azido-2′,3′-dideoxythymine (AZT) and the role of ras mutational activation in skin tumors induced in a two-stage mouse skin model. In addition, mouse live

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f73e378ecbc2e768335049a8239359a2
https://doi.org/10.1002/(sici)1098-2744(199809)23:1<45::aid-mc6>3.0.co

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