Zobrazeno 1 - 10
of 1 567
pro vyhledávání: '"Daniel Levy"'
Autor:
Morteza Naghavi, Anthony P. Reeves, Kyle Atlas, Chenyu Zhang, Thomas Atlas, Claudia I. Henschke, David F. Yankelevitz, Matthew J. Budoff, Dong Li, Sion K. Roy, Khurram Nasir, Sabee Molloi, Zahi Fayad, Michael V. McConnell, Ioannis Kakadiaris, David J. Maron, Jagat Narula, Kim Williams, Prediman K. Shah, Daniel Levy, Nathan D. Wong
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Coronary artery calcium (CAC) scans contain valuable information beyond the Agatston Score which is currently reported for predicting coronary heart disease (CHD) only. We examined whether new artificial intelligence (AI) applied to CAC scan
Externí odkaz:
https://doaj.org/article/5dcdbca0040f43b1b76088122904b1dd
Autor:
Helena Bui, Amena Keshawarz, Mengyao Wang, Mikyeong Lee, Scott M. Ratliff, Lisha Lin, Kira S. Birditt, Jessica D. Faul, Annette Peters, Christian Gieger, Thomas Delerue, Sharon L. R. Kardia, Wei Zhao, Xiuqing Guo, Jie Yao, Jerome I. Rotter, Yi Li, Xue Liu, Dan Liu, Juliana F. Tavares, Gökhan Pehlivan, Monique M. B. Breteler, Irma Karabegovic, Carolina Ochoa-Rosales, Trudy Voortman, Mohsen Ghanbari, Joyce B. J. van Meurs, Mohamed Kamal Nasr, Marcus Dörr, Hans J. Grabe, Stephanie J. London, Alexander Teumer, Melanie Waldenberger, David R. Weir, Jennifer A. Smith, Daniel Levy, Jiantao Ma, Chunyu Liu
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Epigenome‐wide association studies have identified multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. This study aimed to test the hypothesi
Externí odkaz:
https://doaj.org/article/778cf18febfb469f98f4928da01f6554
Autor:
Rima Mustafa, Michelle M. J. Mens, Arno van Hilten, Jian Huang, Gennady Roshchupkin, Tianxiao Huan, Linda Broer, Joyce B. J. van Meurs, Paul Elliott, Daniel Levy, M. Arfan Ikram, Marina Evangelou, Abbas Dehghan, Mohsen Ghanbari
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Background MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Perturbations in plasma miRNA levels are known to impact disease risk and have potential as disease biomarkers. Exploring the genet
Externí odkaz:
https://doaj.org/article/625b253401c940869bcf67b3973bd481
Autor:
Mariana F. Ramirez, Abigail S. Pan, Juhi K. Parekh, Ndidi Owunna, Paul Courchesne, Martin G. Larson, Daniel Levy, Joanne M. Murabito, Jennifer E. Ho, Emily S. Lau
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 22 (2024)
Background Sex differences in obesity and fat distribution may in part explain differences in cardiovascular risk in men versus women. We sought to examine sex differences in the associations of obesity and adiposity measures with cardiovascular dise
Externí odkaz:
https://doaj.org/article/9d98387cdbf949fba5fe7324c74c912c
Autor:
Tianxiao Huan, Roby Joehanes, Jian Rong, Ming-Huei Chen, Rima Mustafa, Abbas Dehghan, Mohsen Ghanbari, Hannah Karlin, Shih-Jen Hwang, Paul Courchesne, Martin G. Larson, Andrew D. Johnson, Jane E. Freedman, Daniel Levy
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110988- (2024)
Summary: MicroRNAs, crucial in regulating protein-coding gene expression, are implicated in various diseases. We performed a genome-wide association study of plasma miRNAs (ex-miRNAs) in 3,743 Framingham Heart Study (FHS) participants and identified
Externí odkaz:
https://doaj.org/article/0af562d70c8345678e66f7cd70367565
Autor:
Yana Hrytsenko, Benjamin Shea, Michael Elgart, Nuzulul Kurniansyah, Genevieve Lyons, Alanna C. Morrison, April P. Carson, Bernhard Haring, Braxton D. Mitchell, Bruce M. Psaty, Byron C. Jaeger, C. Charles Gu, Charles Kooperberg, Daniel Levy, Donald Lloyd-Jones, Eunhee Choi, Jennifer A. Brody, Jennifer A. Smith, Jerome I. Rotter, Matthew Moll, Myriam Fornage, Noah Simon, Peter Castaldi, Ramon Casanova, Ren-Hua Chung, Robert Kaplan, Ruth J. F. Loos, Sharon L. R. Kardia, Stephen S. Rich, Susan Redline, Tanika Kelly, Timothy O’Connor, Wei Zhao, Wonji Kim, Xiuqing Guo, Yii-Der Ida Chen, The Trans-Omics in Precision Medicine Consortium, Tamar Sofer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model ensemble, consisting of
Externí odkaz:
https://doaj.org/article/322241f378754ea881e603a18375361b
Autor:
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger st
Externí odkaz:
https://doaj.org/article/1250c0a2d37c41cbad1c671a34d1b82b
Autor:
Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTSystemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understoo
Externí odkaz:
https://doaj.org/article/f6942193d47e4a7095b9b17d360571e0
Autor:
Hannah Karlin, Meera Sooda, Martin Larson, Jian Rong, Tianxiao Huan, Michelle M. J. Mens, Frank J. A. van Rooij, M. Arfan Ikram, Paul Courchesne, Jane E. Freedman, Roby Joehanes, Gregory P. Mueller, Maryam Kavousi, Mohsen Ghanbari, Daniel Levy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Background Extracellular microRNAs (miRNAs) are a class of noncoding RNAs that remain stable in the extracellular milieu, where they contribute to various physiological and pathological processes by facilitating intercellular signaling. Previous stud
Externí odkaz:
https://doaj.org/article/e66624d074dc42bb91bda8fc2daebc56
Autor:
Madeleine Carbonneau, Yi Li, Brenton Prescott, Chunyu Liu, Tianxiao Huan, Roby Joehanes, Joanne M. Murabito, Nancy L. Heard‐Costa, Vanessa Xanthakis, Daniel Levy, Jiantao Ma
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 11 (2024)
Background Life's Essential 8 (LE8) is an enhanced metric for cardiovascular health. The interrelations among LE8, biomarkers of aging, and disease risks are unclear. Methods and Results LE8 score was calculated for 5682 Framingham Heart Study partic
Externí odkaz:
https://doaj.org/article/1b64265b7fdb4c7e8fcd7a1aec80b27c