Výsledky vyhledávání - "Daniel Levner"

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

Autor: Anna Herland, Ben Swenor, Daniel Levner, Olivier Y.F. Henry, Sasan Jalili-Firoozinezhad, Angeliki Chalkiadaki, Henry Sanchez, Andrzej Przekwas, Sauveur S. F. Jeanty, Rachelle Prantil-Baun, Josiah Sliz, Youngjae Choe, Kyung-Jin Jang, Moran Yadid, Susan Marquez, Chris Hinojosa, Thomas C. Ferrante, Blakely B. O'Connor, Tiama Hamkins-Indik, Rachel Fleming, Stephanie Dauth, Janna Nawroth, Morgan Burt, Ben M. Maoz, David B. Chou, Aaron Delahanty, John P. Ferrier, Anthony Bahinski, Jose Fernandez-Alcon, Bret Nestor, Guy Robert Thompson, Lian Leng, Robert Mannix, Michael J. Cronce, Yuka Milton, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Tae-Eun Park, Miles Ingram, Edward A. FitzGerald, Debarun Das, Ville J. Kujala, Josue A. Goss, George J. Touloumes, Toni Divic, Carlos F. Ng, Oren Levy, Zachary Tranchemontagne, Elizabeth Calamari, Geraldine A. Hamilton, Alexander Cho, Thomas Grevesse, Norman Wen, Tessa Huffstater, Donald E. Ingber, Kevin Kit Parker, Richard M. Novak

Publikováno v: Nature Biomedical Engineering. 4:407-420

Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea94accc104e59d5af0303d98dc1c94f
https://doi.org/10.1038/s41551-019-0497-x

Zobrazit plný text záznamu

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

Human organ-on-a-chip (Organ-Chip) technology has the potential to disrupt preclinical drug discovery and improve success in drug development pipelines as it can recapitulate organ-level pathophysiology and clinical responses. The Innovation and Qual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a356d70f36120aa259a4974531c27107
https://doi.org/10.1101/2021.12.14.472674

Zobrazit plný text záznamu

A robotic platform for fluidically-linked human body-on-chips experimentation

Autor: Ben M. Maoz, Sasan Jalili-Firoozinezhad, Andrzej Przekwas, Carlos F. Ng, Alexander Cho, Anna Herland, Jose Fernandez-Alcon, Daniel Levner, Olivier Y.F. Henry, Janna Nawroth, Blakely B. O'Connor, Debarun Das, David B. Chou, Kevin Kit Parker, Anthony Bahinski, Morgan Burt, Ville J. Kujala, Susan Clauson, Mahadevabharath R. Somayaji, Thomas C. Ferrante, Ben Swenor, Henry Sanchez, Lian Leng, Tessa Huffstater, Angeliki Chalkiadaki, Miles Ingram, Donald E. Ingber, Tiama Hamkins-Indik, Norman Wen, Rachelle Prantil-Baun, Youngjae Choe, Josiah Sliz, Zachary Tranchemontagne, Bret Nestor, George J. Touloumes, Rachel Fleming, Guy Robert Thompson, Alexandra Sontheimer-Phelps, Josue A. Goss, Oren Levy, Toni Divic, Elizabeth Calamari, Sauveur S. F. Jeanty, Kyung-Jin Jang, Michael J. Cronce, Yuka Milton, Richard M. Novak, Geraldine A. Hamilton, Thomas Grevesse, Chris Hinojosa, Moran Yadid, Stephanie Dauth, John P. Ferrier, Tae-Eun Park, Robert Mannix, Edward A. FitzGerald, Aaron Delahanty

Publikováno v: Nat Biomed Eng

Here we describe of an ‘Interrogator’ instrument that uses liquid-handling robotics, a custom software package, and an integrated mobile microscope to enable automated culture, perfusion, medium addition, fluidic linking, sample collection, andin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91904c828996f1d91cb14b8c52e98514
https://doi.org/10.1101/569541

Zobrazit plný text záznamu

SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

Autor: Karel Domansky, Geraldine A. Hamilton, Daniel Levner, Tiama Hamkins-Indik, Donald E. Ingber, Christopher David Hinojosa, Josiah Sliz, Guy Robert Thompson, Jacob P. Fraser, Norman Wen

Publikováno v: Microfluidics and Nanofluidics. 21

The majority of microfluidic devices used for cell culture, including Organ-on-a-Chips (Organ Chips), are fabricated using polydimethylsiloxane (PDMS) polymer because it is flexible, optically clear, and easy to mold. However, PDMS possesses signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78b19f036aab13ba31a571a23dd96a4d
https://doi.org/10.1007/s10404-017-1941-4

Zobrazit plný text záznamu

Barcoding cells using cell-surface programmable DNA-binding domains

Autor: Daniel Levner, Prashant Mali, John Aach, Lisa Nip, George M. Church, Je-Hyuk Lee

Publikováno v: Nature methods

We report an approach to barcode cells through cell-surface expression of programmable zinc-finger DNA-binding domains (surface zinc fingers, sZFs). We show that sZFs enable sequence-specific labeling of living cells by dsDNA, and we develop a sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1209707ff23a41e2d58e867f6d2113b
http://europepmc.org/articles/PMC3641172

Zobrazit plný text záznamu

Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA

Autor: Daniel Levner, Ralf Jungmann, Peng Yin, Chenxiang Lin, Andrew M. Leifer, Chao Li, George M. Church, William M. Shih

Publikováno v: Nature Chemistry. 4:832-839

The identification and differentiation of a large number of distinct molecular species with high temporal and spatial resolution is a major challenge in biomedical science. Fluorescence microscopy is a powerful tool, but its multiplexing ability is l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af45ab2666ca97ba3c88acc31d74d4e
https://doi.org/10.1038/nchem.1451

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání